Reduced memory in fat mass and obesity-associated allele carriers among older adults with cardiovascular disease

Psychogeriatrics

Volumn 13, Issue 1, 2013, Pages 35-40

  Alosco, Michael L ^a   Benitez, Andreana ^c   Gunstad, John ^a,b   Spitznagel, Mary Beth ^a,b   Mccaffery, Jeanne M ^d   Mcgeary, John E ^d,e   Poppas, Athena ^f   Paul, Robert H ^g   Sweet, Lawrence H ^d   Cohen, Ronald A ^d  

^a KENT STATE UNIVERSITY   (United States)

^b SUMMA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BROWN UNIVERSITY   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f Rhode Island Medical Center   (United States)

^g UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

Cardiovascular disease; Cognitive function; FTO risk allele; Memory; Obesity

Indexed keywords

ADULT; ALLELE; ARTICLE; CARDIOVASCULAR DISEASE; EDUCATION; EXECUTIVE FUNCTION; FAT MASS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; LANGUAGE; MAJOR CLINICAL STUDY; MALE; MEMORY; MULTIVARIATE ANALYSIS OF COVARIANCE; NEUROPSYCHOLOGICAL TEST; OBESITY; OUTPATIENT; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; RECALL;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALLELES; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; EXECUTIVE FUNCTION; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MEMORY; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; PSYCHOMOTOR PERFORMANCE;

EID: 84875664101     PISSN: 13463500     EISSN: 14798301     Source Type: Journal    
DOI: 10.1111/j.1479-8301.2012.00424.x     Document Type: Article

References (37)

1. Withrow D, Alter DA. The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obes Rev 2011; 12: 131-141.
2. Patterson RE, Frank LL, Kristal AR, White E. A comprehensive examination of health conditions associated with obesity in older adults. Am J Prev Med 2004; 27: 385-390.
3. Willer CJ, Speliotes EK, Loos RJF etal. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
4. Peng S, Zhu Y, Xu F, Ren X, Li X, Lai M. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med 2011; 9: 71.
5. Frayling TM, Timpson NJ, Weedon MN etal. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
6. Ahmad T, Chasman DI, Mora S etal. The f-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women. Am Heart J 2007; 160: 1163-1169.
7. Okonkwo OC, Cohen RA, Gunstad J, Tremont G, Alosco ML, Poppas A. Longitudinal trajectories of cognitive decline among older adults with cardiovascular disease. Cerebrovasc Dis 2010; 30: 362-373.
8. Bruce DG, Casey GP, Grange V etal. Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study. Diabetes Res Clin Pract 2003; 16: 59-67.
9. Ho AJ, Stein JL, Hua X etal. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A 2010; 107: 8404-8409.
10. Keller L, Xu W, Wang HX, Winblad B, Fratiglioni L, Graff C. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis 2011; 23: 461-469.
11. Benedict C, Jacobsson JA, Ronnemaa E etal. The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men. Neurobiol Aging 2011; 32: 1159. e1-5.
12. Spreen O, Strauss E. A Compendium of Neuropsychological Tests. New York, NY: Oxford University Press, 1991.
13. Dikmen S, Heaton R, Grant I, Temkin N. Test-retest reliability of the Expanded Halstead-Reitan Neuropsychological Test Battery. J Int Neuropsychol Soc 1999; 5: 346-356.
14. Wechsler D. Manual for the Wechsler Adult Intelligence Scale, 3rd edn. San Antonio, TX: The Psychological Corporation, 1997.
15. Delis D, Kramer J, Kaplan E, Ober B. Manual: California Verbal Learning Test, Adult Version. San Antonio, TX: Psychological Corporation, 1987.
16. Kaplan E, Goodglass H, Weintraub S. Boston Naming Test. Philadelphia, PA: Lea and Febiger, 1983.
17. Morris JC, Heyman A, Mohs RC etal. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989; 39: 1159-1165.
18. Hooper H. The Hooper Visual Organization Test. Los Angeles, CA: Western Psychological Services, 1983.
19. Bressler J, Linda Kao WH, Pankow JS, Boerwinkle E. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in Whites and African-Americans in the ARIC Study. PLoS One 2010; 5: 1-8.
20. Wolk DA, Dickerson BC, Alzheimers Disease Neuroimaging Intiative. Apolipoprotein E (APOE) genotype has dissociable effects on memory on memory and attention-executive network function in Alzheimer's disease. Proc Natl Acad Sci U S A 2010; 107: 10256-10261.
21. Persson J, Lind J, Larsson A etal. Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD? Neurology 2006; 66: 1029-1033.
22. Gunstad J, Lhotsky A, Wendell CR, Ferrucci L, Zonderman AB. Longitudinal examination of obesity and cognitive function: results from the Baltimore longitudinal study of aging. Neuroepidemiology 2010; 34: 222-229.
23. Gustafson D, Lissner L, Bengtsson C, Björkelund C, Skoog I. A 24-year follow-up of body mass index and cerebral atrophy. Neurology 2004; 63: 1876 - 1881.
24. Vogels RL, Oosterman JM, van Harten B etal. Neuroimaging and correlates of cognitive function among patients with heart failure. Dement Geriatr Cogn Disord 2007; 24: 418-423.
25. Davignon J, Gregg RE, Sing SF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988; 8: 1-21.
26. Kuusi T, Nieminen MS, Ehnholm C etal. Apolipoprotein E polymorphism and coronary artery disease: increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients. Arteriosclerosis 1989; 9: 237-241.
27. van Bockxmeer FM, Mamotte CDS. Apolipoprotein epsilon 4 homozygosity in young men with coronary heart disease. Lancet 1992; 340: 879-880.
28. Mielke MM, Leoutsakos JM, Tschanz JT etal. Interaction between vascular factors and the APOE ε4 allele in predicting rate of progression in Alzheimer's disease. J Alzheimers Dis 2011; 26: 127-134.
29. Peila R, White LR, Ptrovich H etal. Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging study. Stroke 2001; 32: 2882-2889.
30. Cohen RA. Obesity-associated cognitive decline: excess weight affects more than the waistline. Neuroepidemiology 2010; 34: 230-231.
31. Cohen RA, Gunstad JG, eds. Neuropsychology of Cardiovascular Disease. New York, NY: Oxford University Press, 2010.
32. Joseph RJ, Alonso-Alonso M, Bonds DS, Pascual-Leone A, Blackburn GL. The neurocognitive connections between physical activity and eating behavior. Obes Rev 2011; 12: 800-812.
33. Lappalainen T, Kolehmainen M, Schwab US etal. Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism - The Finnish Diabetes Prevention Study. Nutr Metab Cardiovasc Dis 2011; 21: 691-698.
34. Peng S, Zhu Y, Xu F etal. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med 2011; 8: 71.
35. Liu Y, Liu Z, Song Y etal. Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity (Silver Spring) 2010; 18: 1619-1624.
36. Ramya K, Radha V, Ghosh S etal. Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79). Diabetes Technol Ther 2011; 13: 33-42.
37. Kauppi K, Nilsson LG, Adolfsson R. KIBRA polymorphism is related to enhanced memory and elevated hippocampal processing. J Neurosci 2011; 31: 14218-14222.