Applying Mathematical Tools to Accelerate Vaccine Development: Modeling Shigella Immune Dynamics

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Davis, Courtney L ^a   Wahid, Rezwanul ^b   Toapanta, Franklin R ^b   Simon, Jakub K ^c   Sztein, Marcelo B ^b   Levy, Doron ^d  

^a PEPPERDINE UNIVERSITY   (United States)

^b University of Maryland School of Medicine Center for Vaccine Development   (United States)

^c NanoBio Corporation   (United States)

^d University of Maryland   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; MEMBRANE ANTIGEN; SHIGELLA VACCINE;

ARTICLE; CALCULATION; DRUG DESIGN; DRUG TARGETING; IMMUNE RESPONSE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MEMORY CELL; SHIGELLA; VACCINE PRODUCTION;

ALGORITHMS; ANTIBODIES, BACTERIAL; COMPUTER SIMULATION; DYSENTERY, BACILLARY; HOST-PATHOGEN INTERACTIONS; HUMANS; INTESTINAL MUCOSA; MODELS, IMMUNOLOGICAL; SHIGELLA; SHIGELLA VACCINES;

BACTERIA (MICROORGANISMS); SHIGELLA;

EID: 84875663033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059465     Document Type: Article

References (55)

1. Organization WH (Mar 2009) Vaccine-Preventable Diseases and Immunization. Electronic Citation.
2. Kweon M, (2008) Shigellosis: the current status of vaccine development. Current Opinion in Infec-tious Diseases 21: 313.
3. Levine M, Kotloff K, Barry E, Pasetti M, Sztein M, (2007) Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road. Nature Reviews Microbiology 5: 540-553.
4. Phalipon A, Sansonetti P, (2007) Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival? Immunology and Cell Biology 85: 119-129.
5. Organization WH (2009). Shigellosis: Disease Burden. Electronic Citation.
6. Plotkin SA, Gilbert PB, (2012) Nomenclature for immune correlates of protection after vaccination. Clin Infect Dis 54: 1615-7.
7. Simon J, Wahid R, Maciel M, Picking W, Kotloff K, et al. (2009) Antigen-specific B memory cell responses to lipopolysaccharide (LPS) and invasion plasmid antigen (Ipa) B elicited in volunteers vaccinated with live-attenuated Shigella flexneri 2a vaccine candidates. Vaccine 27: 565-572.
8. Simon JK, Maciel J M, Weld ED, Wahid R, Pasetti MF, et al. (2011) Antigen-specific iga b memory cell responses to shigella antigens elicited in volunteers immunized with live attenuated shigella flexneri 2a oral vaccine candidates. Clin Immunol 139: 185-92.
9. Ashida H, OgawaM, Mimuro H, Kobayashi T, Sanada T, et al. (2011) Shigella are versatile mucosal pathogens that circumvent the host innate immune system. Curr Opin Immunol 23: 448-55.
10. Phalipon A, Sansonetti PJ, (2007) Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival? Immunol Cell Biol 85: 119-29.
11. Sansonetti P, Phalipon A, (1996) Shigellosis: from molecular pathogenesis of infection to protective immunity and vaccine development. Research in Immunology 147: 595-602.
12. Phalipon A, Sansonetti P, (2003) Shigellosis: innate mechanisms of inflammatory destruction of the intestinal epithelium, adaptive immune response, and vaccine development. Critical Reviews in Immunology 23: 371-401.
13. Janeway C, Travers P, Walport M, Shlomchik M (2001) Immunobiology. Current Biology Publi-cations.
14. Brandtzaeg P, (2009) Mucosal immunity: induction, dissemination, and effector functions. Scand J Immunol 70: 505-15.
15. Baker K, Qiao SW, Kuo T, Kobayashi K, Yoshida M, et al. (2009) Immune and non-immune functions of the (not so) neonatal fc receptor, fcrn. Semin Immunopathol 31: 223-36.
16. Brandtzaeg P, Johansen FE, (2005) Mucosal b cells: phenotypic characteristics, transcriptional regulation, and homing properties. Immunol Rev 206: 32-63.
17. Brandtzaeg P, (2007) Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25: 5467-5484.
18. DuPont H, Hornick R, Snyder M, Libonati J, Formal S, et al. (1972) Immunity in shigellosis. II. Protection induced by oral live vaccine or primary infection. J Infect Dis 125: 12-16.
19. DuPont H, Levine M, Hornick R, Formal S, (1989) Inoculum size in shigellosis and implications for expected mode of transmission. J Infect Dis 159: 1126-1128.
20. Raqib R, Ljungdahl A, Lindberg A, Andersson U, Andersson J, (1996) Local entrapment of interferon gamma in the recovery from shigella dysenteriae type 1 infection. Gut 38: 328-336.
21. Raqib R, Wretlind B, Andersson J, Lindberg AA, (1995) Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma. J Infect Dis 171: 376-84.
22. Raqib R, Wretlind B, Andersson J, Lindberg A (1995) Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma. The Journal of Infectious Diseases: 376-384.
23. Samandari T, Kotloff KL, Losonsky GA, Picking WD, Sansonetti PJ, et al. (2000) Production of ifn-gamma and il-10 to shigella invasins by mononuclear cells from volunteers orally inoculated with a shiga toxin-deleted shigella dysenteriae type 1 strain. J Immunol 164: 2221-32.
24. Islam D, Bardhan PK, Lindberg AA, Christensson B, (1995) Shigella infection induces cellular activation of t and b cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease. Infect Immun 63: 2941-9.
25. Islam D, Wretlind B, Lindberg AA, Christensson B, (1996) Changes in the peripheral blood t-cell receptor v beta repertoire in vivo and in vitro during shigellosis. Infect Immun 64: 1391-9.
26. Kotloff KL, Noriega FR, Samandari T, Sztein MB, Losonsky GA, et al. (2000) Shigella flexneri 2a strain cvd 1207, with specific deletions in virg, sen, set, and guaba, is highly attenuated in humans. Infect Immun 68: 1034-9.
27. Kotloff KL, Taylor DN, Sztein MB, Wasserman SS, Losonsky GA, et al. (2002) Phase i evaluation of delta virg shigella sonnei live, attenuated, oral vaccine strain wrss1 in healthy adults. Infect Immun 70: 2016-21.
28. Niesel DW, Hess CB, Cho YJ, Klimpel KD, Klimpel GR, (1986) Natural and recombinant interferons inhibit epithelial cell invasion by shigella spp. Infect Immun 52: 828-33.
29. Le-Barillec K, Magalhaes J, Corcuff E, Thuizat A, Sansonetti P, et al. (2005) Roles for T and NK Cells in the innate immune response to Shigella flexneri. Journal of Immunology 175: 1735-1740.
30. Nowak M, May R (2000) Virus dynamics: mathematical principles of immunology and virology. Oxford University Press, USA.
31. Perelson A, et al. (2002) Modelling viral and immune system dynamics. Nature Reviews Immunology 2: 28-36.
32. Bru A, Cardona PJ, (2010) Mathematical modeling of tuberculosis bacillary counts and cellular populations in the organs of infected mice. PLoS One 5: e12985.
33. Marino S, Linderman JJ, Kirschner DE, (2011) A multifaceted approach to modeling the immune response in tuberculosis. Wiley Interdiscip Rev Syst Biol Med 3: 479-89.
34. Marino S, Myers A, Flynn JL, Kirschner DE, (2010) Tnf and il-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model. J Theor Biol 265: 586-98.
35. Hancioglu B, Swigon D, Clermont G, (2007) A dynamical model of human immune response to influenza a virus infection. J Theor Biol 246: 70-86.
36. Jansen V, Korthals Altes H, Funk G, Wodarz D, (2005) Contrasting b cell-and t cell-based protective vaccines. Journal of Theoretical Biology 234: 39-48.
37. Saul A, Fay MP, (2007) Human immunity and the design of multi-component, single target vaccines. PLoS One 2: e850.
38. Kotloff KL, Herrington DA, Hale TL, Newland JW, Van De Verg L, et al. (1992) Safety, im-munogenicity, and efficacy in monkeys and humans of invasive escherichia coli k-12 hybrid vaccine candidates expressing shigella flexneri 2a somatic antigen. Infect Immun 60: 2218-24.
39. Kotloff K, Losonsky G, Nataro J, Wasserman S, Hale T, et al. (1995) Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli- Shigella flexneri 2a vaccine strain EcSf2a-2. Vaccine 13: 495-502.
40. Kotloff K, Nataro J, Losonsky G, Wasserman S, Hale T, et al. (1995) A modified shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for shigella infectivity. Vaccine 13: 1488-1494.
41. Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, et al. (2010) Th17 cells are the dominant t cell subtype primed by shigella flexneri mediating protective immunity. J Immunol 184: 2076-85.
42. Amanna I, Slifka M, (2010) Mechanisms that determine plasma cell lifespan and the duration of humoral immunity. Immunological Reviews 236: 125-138.
43. Riddle MS, Kaminski RW, Williams C, Porter C, Baqar S, et al. (2011) Safety and immunogenicity of an intranasal shigella flexneri 2a invaplex 50 vaccine. Vaccine 29: 7009-19.
44. Koterski JF, Nahvi M, Venkatesan MM, Haimovich B, (2005) Virulent shigella flexneri causes damage to mitochondria and triggers necrosis in infected human monocyte-derived macrophages. Infect Immun 73: 504-13.
45. Cersini A, Salvia AM, Bernardini ML, (1998) Intracellular multiplication and virulence of shigella flexneri auxotrophic mutants. Infect Immun 66: 549-57.
46. Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, et al. (2005) Escape of intracellular shigella from autophagy. Science 307: 727-31.
47. Levy M, Vieira P, Coutinho A, Freitas A, (1987) The majority of "natural" immunoglobulinsecreting cells are short-lived and the progeny of cycling lymphocytes. Eur J Immunol 17: 849-854.
48. Slifka M, Ahmed R, (1998) Long-lived plasma cells: a mechanism for maintaining persistent anti- body production. Curr Opin Immunol 10: 252-258.
49. Gray D, Skarvall H, (1988) B-cell memory is short-lived in the absence of antigen. Nature 336: 70-73.
50. Perdomo JJ, Gounon P, Sansonetti PJ, (1994) Polymorphonuclear leukocyte transmigration pro- motes invasion of colonic epithelial monolayer by shigella flexneri. J Clin Invest 93: 633-43.
51. Stendahl O, Tagesson C, Magnusson KE, Edebo L, (1977) Physicichemical consequences of op- sonization of Shigella typhimurium with hyperimmune IgG and complement. Immunology 32: 11-18.
52. Conrad R, Ingraham J, (1974) Rate of hemolytic antibody production by single cells in vivo in rabbits. J Immunol 112: 17-25.
53. Helmreich E, Kern M, Eisen H, (1961) The secretion of antibody by isolated lymph node cells. J Biol Chem 236: 464-473.
54. Helmreich E, Kern M, Eisen H, (1962) Observations on the mechanism of secretion of g-globulins by isolated lymph node cells. J Biol Chem 237: 1925-1931.
55. Hibi T, Dosch H, (1986) Limiting dilution analysis of the B cell compartment in human bone marrow. Eur J Immunol 16: 139-145.