The Role of TLR2, TLR4 and CD14 Genetic Polymorphisms in Gastric Carcinogenesis: A Case-Control Study and Meta-Analysis

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Castaño Rodríguez, Natalia ^a   Kaakoush, Nadeem O ^a   Goh, Khean Lee ^b   Fock, Kwong Ming ^c   Mitchell, Hazel M ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c CHANGI GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CYSTINE; THREONINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

AGED; ALLELE; ARTICLE; CANCER PREVENTION; CANCER RISK; CASE CONTROL STUDY; CD14 GENE; CHINESE; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE; GENE DELETION; GENE FREQUENCY; GENE FUNCTION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HELICOBACTER INFECTION; HUMAN; INDEL MUTATION; JAPANESE; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; META ANALYSIS (TOPIC); REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; STOMACH CANCER; STOMACH CARCINOGENESIS; TLR2 GENE; TLR4 GENE;

ADULT; AGED; ANTIGENS, CD14; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENETIC ASSOCIATION STUDIES; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; PUBLICATION BIAS; STOMACH NEOPLASMS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

HELICOBACTER PYLORI;

EID: 84875653192     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060327     Document Type: Article

References (70)

1. Lochhead P, El-Omar EM, (2008) Gastric cancer. Br Med Bull 85: 87-100.
2. Parkin DM, Bray F, Ferlay J, Pisani P, (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108.
3. Brenner H, Rothenbacher D, Arndt V, (2009) Epidemiology of stomach cancer. Methods Mol Biol 472: 467-477.
4. Goh KL, Cheah PL, Md N, Quek KF, Parasakthi N, (2007) Ethnicity and H. pylori as risk factors for gastric cancer in Malaysia: A prospective case control study. Am J Gastroenterol 102: 40-45.
5. Merchant JL, (2005) Inflammation, atrophy, gastric cancer: connecting the molecular dots. Gastroenterology 129: 1079-1082.
6. Correa P, (1988) A human model of gastric carcinogenesis. Cancer Res 48: 3554-3560.
7. Gonzalez CA, Sala N, Capella G, (2002) Genetic susceptibility and gastric cancer risk. Int J Cancer 100: 249-260.
8. Kusters JG, van Vliet AH, Kuipers EJ, (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19: 449-490.
9. Li H, Stoicov C, Cai X, Wang TC, Houghton J, (2003) Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility. Curr Gastroenterol Rep 5: 459-467.
10. Lochhead P, El-Omar EM, (2007) Helicobacter pylori infection and gastric cancer. Best Pract Res Clin Gastroenterol 21: 281-297.
11. Wroblewski LE, Peek RM Jr, Wilson KT, (2010) Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 23: 713-739.
12. Takeda K, Kaisho T, Akira S, (2003) Toll-like receptors. Annu Rev Immunol 21: 335-376.
13. Su B, Ceponis PJ, Lebel S, Huynh H, Sherman PM, (2003) Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun 71: 3496-3502.
14. Thomas CJ, Kapoor M, Sharma S, Bausinger H, Zyilan U, et al. (2002) Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response. FEBS Lett 531: 184-188.
15. Chochi K, Ichikura T, Kinoshita M, Majima T, Shinomiya N, et al. (2008) Helicobacter pylori augments growth of gastric cancers via the lipopolysaccharide-toll-like receptor 4 pathway whereas its lipopolysaccharide attenuates antitumor activities of human mononuclear cells. Clin Cancer Res 14: 2909-2917.
16. Ishihara S, Rumi MA, Kadowaki Y, Ortega-Cava CF, Yuki T, et al. (2004) Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol 173: 1406-1416.
17. Smith MF Jr, Mitchell A, Li G, Ding S, Fitzmaurice AM, et al. (2003) Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem 278: 32552-32560.
18. Smith SM, Moran AP, Duggan SP, Ahmed SE, Mohamed AS, et al. (2011) Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide. J Immunol 186: 2462-2471.
19. Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K, (2010) Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun 78: 468-476.
20. Mandal RK, George GP, Mittal RD, (2012) Association of Toll-like receptor (TLR) 2, 3 and 9 genes polymorphism with prostate cancer risk in North Indian population. Mol Biol Rep 39: 7263-7269.
21. Pandey S, Mittal RD, Srivastava M, Srivastava K, Singh S, et al. (2009) Impact of Toll-like receptors [TLR] 2 (-196 to-174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women. Gynecol Oncol 114: 501-505.
22. Singh V, Srivastava N, Kapoor R, Mittal RD, (2012) Single-nucleotide Polymorphisms in Genes Encoding Toll-like Receptor-2,-3,-4, and-9 in a Case-Control Study with Bladder Cancer Susceptibility in a North Indian Population. Arch Med Res.
23. Srivastava K, Srivastava A, Kumar A, Mittal B, (2010) Significant association between toll-like receptor gene polymorphisms and gallbladder cancer. Liver Int 30: 1067-1072.
24. Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, et al. (2007) Toll-like receptor 2-196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci 98: 1790-1794.
25. Kiechl S, Wiedermann CJ, Willeit J, (2003) Toll-like receptor 4 and atherogenesis. Ann Med 35: 164-171.
26. Mockenhaupt FP, Cramer JP, Hamann L, Stegemann MS, Eckert J, et al. (2006) Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria. J Commun Dis 38: 230-245.
27. Zhang K, Zhou B, Wang Y, Rao L, Zhang L, (2012) The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis. Eur J Cancer.
28. Fukusaki T, Ohara N, Hara Y, Yoshimura A, Yoshiura K, (2007) Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. J Periodontal Res 42: 541-545.
29. Hubacek JA, Rothe G, Pit'ha J, Skodova Z, Stanek V, et al. (1999) C(-260)-->T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 99: 3218-3220.
30. LeVan TD, Bloom JW, Bailey TJ, Karp CL, Halonen M, et al. (2001) A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 167: 5838-5844.
31. Jing JJ, Li M, Yuan Y, (2012) Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: a meta-analysis. Gene 499: 237-242.
32. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, et al. (1999) Functional gastroduodenal disorders. Gut 45 (Suppl 2):: II37-42.
33. Castano-Rodriguez N, Kaakoush NO, Goh KL, Fock KM, Chionh YT, et al. (2012) PAR-1 polymorphisms and risk of Helicobacter pylori-related gastric cancer in a Chinese population. Anticancer Res 32: 3715-3721.
34. Jurinke C, van den Boom D, Cantor CR, Koster H, (2002) The use of MassARRAY technology for high throughput genotyping. Adv Biochem Eng Biotechnol 77: 57-74.
35. Oeth P BM, Park C, Kosman D, del Mistro G, van den Boom D, Jurinke C, (2005) iPLEX™ Assay: Increased Plexing Efficiency and Flexibility for MassARRAY System Through Single Base Primer Extension with Mass-Modified Terminators. Sequenom pp. pp. 12.
36. Hazbon MH, Alland D, (2004) Hairpin primers for simplified single-nucleotide polymorphism analysis of Mycobacterium tuberculosis and other organisms. J Clin Microbiol 42: 1236-1242.
37. Chan WF, Maharjan RP, Reeves PR, Sintchenko V, Gilbert GL, et al. (2009) Rapid and accurate typing of Bordetella pertussis targeting genes encoding acellular vaccine antigens using real time PCR and High Resolution Melt analysis. J Microbiol Methods 77: 326-329.
38. Schmidt HM, Ha DM, Taylor EF, Kovach Z, Goh KL, et al. (2011) Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi-ethnic country. J Gastroenterol Hepatol 26: 1725-1732.
39. Mitchell H, English DR, Elliott F, Gengos M, Barrett JH, et al. (2008) Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer. Aliment Pharmacol Ther 28: 903-910.
40. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
41. de Oliveira JG, Silva AE, (2012) Polymorphisms of the TLR2 and TLR4 genes are associated with risk of gastric cancer in a Brazilian population. World J Gastroenterol 18: 1235-1242.
42. Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, et al. (2010) No associations of Toll-like receptor 2 (TLR2)-196 to-174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese. Gastric Cancer 13: 251-257.
43. Zeng HM, Pan KF, Zhang Y, Zhang L, Ma JL, et al. (2011) Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population. Cancer Epidemiol Biomarkers Prev 20: 2594-2602.
44. Garza-Gonzalez E, Bosques-Padilla FJ, Mendoza-Ibarra SI, Flores-Gutierrez JP, Maldonado-Garza HJ, et al. (2007) Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8-251 polymorphisms in the risk for the development of distal gastric cancer. BMC Cancer 7: 70.
45. Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, et al. (2007) A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 132: 905-912.
46. Santini D, Angeletti S, Ruzzo A, Dicuonzo G, Galluzzo S, et al. (2008) Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes. Clin Exp Immunol 154: 360-364.
47. Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, et al. (2009) Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese. Helicobacter 14: 47-53.
48. Kupcinskas J, Wex T, Bornschein J, Selgrad M, Leja M, et al. (2011) Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians. BMC Med Genet 12: 112.
49. Hold GL, Rabkin CS, Gammon MD, Berry SH, Smith MG, et al. (2009) CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations. Eur J Cancer Prev 18: 117-119.
50. Tahara T, Arisawa T, Shibata T, Hirata I, Nakano H, (2007) Association of polymorphism of TLR4 and CD14 genes with gastroduodenal diseases in Japan. Inflammopharmacology 15: 124-128.
51. Wu MS, Cheng TY, Shun CT, Lin MT, Chen LC, et al. (2006) Functional polymorphisms of CD14 and toll-like receptor 4 in Taiwanese Chinese with Helicobacter pylori-related gastric malignancies. Hepatogastroenterology 53: 807-810.
52. Zhao D, Sun T, Zhang X, Guo Y, Yu D, et al. (2007) Role of CD14 promoter polymorphisms in Helicobacter pylori infection--related gastric carcinoma. Clin Cancer Res 13: 2362-2368.
53. Aihara M, Tsuchimoto D, Takizawa H, Azuma A, Wakebe H, et al. (1997) Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 65: 3218-3224.
54. Crowe SE, Alvarez L, Dytoc M, Hunt RH, Muller M, et al. (1995) Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology 108: 65-74.
55. Keates S, Hitti YS, Upton M, Kelly CP, (1997) Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology 113: 1099-1109.
56. Junpee A, Tencomnao T, Sanprasert V, Nuchprayoon S, (2010) Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis. Parasitol Res 107: 807-816.
57. Noguchi E, Nishimura F, Fukai H, Kim J, Ichikawa K, et al. (2004) An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy 34: 177-183.
58. El-Omar EM, Ng MT, Hold GL, (2008) Polymorphisms in Toll-like receptor genes and risk of cancer. Oncogene 27: 244-252.
59. Higgins SC, Lavelle EC, McCann C, Keogh B, McNeela E, et al. (2003) Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 171: 3119-3127.
60. Abbas AK, Lichtman, A H, Pillai S, (2010) Cellular and molecular immunology. Philadelphia: Saunders/Elsevier.
61. Guo Q, Zhu J, Xia B, (2006) Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients. J Gastroenterol Hepatol 21: 92-97.
62. Yuan M, Xia J, Ma L, Xiao B, Yang Q, (2010) Lack of the Toll-Like Receptor 4 Gene Polymorphisms Asp299Gly and Thr399ile in a Chinese Population. Int J Neurosci 120: 415-420.
63. Loh M, Koh KX, Yeo BH, Song CM, Chia KS, et al. (2009) Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. Eur J Cancer 45: 2562-2568.
64. Zheng SL, Augustsson-Balter K, Chang B, Hedelin M, Li L, et al. (2004) Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Res 64: 2918-2922.
65. Kim HJ, Bae JS, Chang IH, Kim KD, Lee J, et al. (2011) Sequence variants of toll-like receptor 4 (TLR4) and the risk of prostate cancer in Korean men. World J Urol.
66. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, et al. (1999) A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol. 20: 976-983.
67. Karhukorpi J, Yan Y, Niemela S, Valtonen J, Koistinen P, et al. (2002) Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14. Clin Exp Immunol 128: 326-332.
68. Liang XH, Cheung W, Heng CK, Liu JJ, Li CW, et al. (2006) CD14 promoter polymorphisms have no functional significance and are not associated with atopic phenotypes. Pharmacogenet Genomics 16: 229-236.
69. Rigoli L, Di Bella C, Fedele F, Procopio V, Amorini M, et al. (2010) TLR4 and NOD2/CARD15 genetic polymorphisms and their possible role in gastric carcinogenesis. Anticancer Res 30: 513-517.
70. Gianfagna F, De Feo E, van Duijn CM, Ricciardi G, Boccia S, (2008) A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk. Curr Genomics 9: 361-374.