Impact of E1 and Cre on Adenovirus Vector Amplification: Developing MDCK CAV-2-E1 and E1-Cre Transcomplementing Cell Lines

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Fernandes, Paulo ^a,b   Santiago, Virgínia M ^a   Rodrigues, Ana F ^a,b   Tomás, Hélio ^a,b   Kremer, Eric J ^c   Alves, Paula M ^a,b   Coroadinha, Ana S ^a,b  

^a INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CRE RECOMBINASE; E1A PROTEIN; E1B PROTEIN; MESSENGER RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANINE ADENOVIRUS; CANINE ADENOVIRUS TYPE 2; CELL CLONE; CELL DENSITY; CELL MATURATION; CELL PROTECTION; CELL SPECIFICITY; CELL VIABILITY; CONTROLLED STUDY; E1A GENE; E1B GENE; ENZYME ACTIVITY; GENE; GENE AMPLIFICATION; GENE EXPRESSION; HUMAN; MDCK CELL; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; VIRUS REPLICATION;

ADENOVIRUS E1 PROTEINS; ADENOVIRUSES, CANINE; ANIMALS; CELL LINE; CELL SURVIVAL; DOGS; GENE EXPRESSION; GENE ORDER; GENETIC VECTORS; INTEGRASES; OXIDATIVE STRESS; VIRUS REPLICATION;

ADENOVIRIDAE; CANINE ADENOVIRUS TYPE 2; CHICKEN ANEMIA VIRUS;

EID: 84875641729     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060342     Document Type: Article

References (45)

1. Bramson JL, Graham FL, Gauldie J, (1995) The use of adenoviral vectors for gene therapy and gene transfer in vivo. Curr Opin Biotechnol 6: 590-595.
2. Kovesdi I, Hedley SJ, (2010) Adenoviral producer cells. Viruses 2: 1681-1703.
3. Berk AJ, (1986) Functions of adenovirus E1A. Cancer Surv 5: 367-387.
4. Liao Y, Yu D, Hung MC, (2007) Novel approaches for chemosensitization of breast cancer cells: the E1A story. Adv Exp Med Biol 608: 144-169.
5. Bernards R, de Leeuw MG, Houweling A, van der Eb AJ, (1986) Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection. Virology 150: 126-139.
6. Houweling A, van den Elsen PJ, van der Eb AJ, (1980) Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA. Virology 105: 537-550.
7. Curriel DT, Douglas JT, editors (2002) Adenoviral Vectors for Gene Therapy. California, U.S.A: Academic Press.
8. Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, et al. (1992) The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci U S A 89: 7742-7746.
9. White E, (1998) Regulation of Apoptosis by Adenovirus E1A and E1B Oncogenes. Seminars in Virology 8: 505-513.
10. White E, Sabbatini P, Debbas M, Wold WS, Kusher DI, et al. (1992) The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha. Mol Cell Biol 12: 2570-2580.
11. Dormond E, Perrier M, Kamen A, (2009) From the first to the third generation adenoviral vector: what parameters are governing the production yield? Biotechnol Adv 27: 133-144.
12. Lieber A, He CY, Kirillova I, Kay MA, (1996) Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 70: 8944-8960.
13. Hardy S, Kitamura M, Harris-Stansil T, Dai Y, Phipps ML, (1997) Construction of adenovirus vectors through Cre-lox recombination. J Virol 71: 1842-1849.
14. Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, et al. (1996) A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A 93: 13565-13570.
15. Bangari DS, Mittal SK, (2006) Current strategies and future directions for eluding adenoviral vector immunity. Curr Gene Ther 6: 215-226.
16. Klonjkowski B, Gilardi-Hebenstreit P, Hadchouel J, Randrianarison V, Boutin S, et al. (1997) A recombinant E1-deleted canine adenoviral vector capable of transduction and expression of a transgene in human-derived cells and in vivo. Hum Gene Ther 8: 2103-2115.
17. Paillard F, (1997) Advantages of non-human adenoviruses versus human adenoviruses. Hum Gene Ther 8: 2007-2009.
18. Thomas CE, Birkett D, Anozie I, Castro MG, Lowenstein PR, (2001) Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain. Mol Ther 3: 36-46.
19. Yang Y, Su Q, Wilson JM, (1996) Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J Virol 70: 7209-7212.
20. Kremer EJ, Boutin S, Chillon M, Danos O, (2000) Canine adenovirus vectors: an alternative for adenovirus-mediated gene transfer. J Virol 74: 505-512.
21. Perreau M, Kremer EJ, (2005) Frequency, proliferation, and activation of human memory T cells induced by a nonhuman adenovirus. J Virol 79: 14595-14605.
22. Keriel A, Rene C, Galer C, Zabner J, Kremer EJ, (2006) Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors. J Virol 80: 1487-1496.
23. Soudais C, Boutin S, Kremer EJ, (2001) Characterization of cis-acting sequences involved in canine adenovirus packaging. Mol Ther 3: 631-640.
24. Soudais C, Laplace-Builhe C, Kissa K, Kremer EJ, (2001) Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo. Faseb J 15: 2283-2285.
25. Soudais C, Skander N, Kremer EJ, (2004) Long-term in vivo transduction of neurons throughout the rat CNS using novel helper-dependent CAV-2 vectors. FASEB J 18: 391-393.
26. Shibata R, Shinagawa M, Iida Y, Tsukiyama T, (1989) Nucleotide sequence of E1 region of canine adenovirus type 2. Virology 172: 460-467.
27. Anton M, Graham FL, (1995) Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression. J Virol 69: 4600-4606.
28. Rodrigues AF, Guerreiro MR, Santiago VM, Dalba C, Klatzmann D, et al. (2011) Down-regulation of CD81 tetraspanin in human cells producing retroviral-based particles: tailoring vector composition. Biotechnol Bioeng 108: 2623-2633.
29. Coroadinha AS, Schucht R, Gama-Norton L, Wirth D, Hauser H, et al. (2006) The use of recombinase mediated cassette exchange in retroviral vector producer cell lines: predictability and efficiency by transgene exchange. J Biotechnol 124: 457-468.
30. Loonstra A, Vooijs M, Beverloo HB, Allak BA, van Drunen E, et al. (2001) Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci U S A 98: 9209-9214.
31. Salinas S, Bilsland LG, Henaff D, Weston AE, Keriel A, et al. (2009) CAR-associated vesicular transport of an adenovirus in motor neuron axons. PLoS Pathog 5: e1000442.
32. Henaff D, Salinas S, (2010) An endocytic CARriage tale: Adenoviruses internalization and trafficking in neurons. Virulence 1: 188-191.
33. Fernandes P, Peixoto C, Santiago VM, Kremer EJ, Coroadinha AS, et al. (2012) Bioprocess development for canine adenovirus type 2 vectors. Gene Ther.
34. Gallimore PH, Turnell AS, (2001) Adenovirus E1A: remodelling the host cell, a life or death experience. Oncogene 20: 7824-7835.
35. Moran E, (1993) DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev 3: 63-70.
36. Berk AJ, (1986) Adenovirus promoters and E1A transactivation. Annu Rev Genet 20: 45-79.
37. Debbas M, White E, (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev 7: 546-554.
38. Schmitz ML, Indorf A, Limbourg FP, Stadtler H, Traenckner EB, et al. (1996) The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K. Mol Cell Biol 16: 4052-4063.
39. Blackford AN, Grand RJ, (2009) Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J Virol 83: 4000-4012.
40. Thyagarajan B, Guimaraes MJ, Groth AC, Calos MP, (2000) Mammalian genomes contain active recombinase recognition sites. Gene 244: 47-54.
41. Araujo FD, Stracker TH, Carson CT, Lee DV, Weitzman MD, (2005) Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol 79: 11382-11391.
42. Baker A, Rohleder KJ, Hanakahi LA, Ketner G, (2007) Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation. J Virol 81: 7034-7040.
43. Ng P, Evelegh C, Cummings D, Graham FL, (2002) Cre levels limit packaging signal excision efficiency in the Cre/loxP helper-dependent adenoviral vector system. J Virol 76: 4181-4189.
44. Dormond E, Perrier M, Kamen A, (2009) Identification of critical infection parameters to control helper-dependent adenoviral vector production. J Biotechnol 142: 142-150.
45. Dormond E, Meneses-Acosta A, Jacob D, Durocher Y, Gilbert R, et al. (2009) An efficient and scalable process for helper-dependent adenoviral vector production using polyethylenimine-adenofection. Biotechnol Bioeng 102: 800-810.