Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Stein, Andrew M ^a   Martinelli, Giovanni ^b   Hughes, Timothy P ^c   Müller, Martin C ^d   Beppu, Lan ^e   Gottardi, Enrico ^f   Branford, Susan ^c   Soverini, Simona ^b   Woodman, Richard C ^g   Hochhaus, Andreas ^h   Kim, Dong Wook ⁱ   Saglio, Giuseppe ^f   Radich, Jerald P ^e  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^d MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF TURIN   (Italy)

^g NOVARTIS PHARMA AG   (Switzerland)

^h JENA UNIVERSITY HOSPITAL   (Germany)

ⁱ The Catholic University of Korea   (South Korea)

Author keywords

BCR ABL; Chronic myeloid leukemia; Mathematical modeling; Molecular response; Nilotinib

Indexed keywords

BCR ABL PROTEIN; BCR ABL1 PROTEIN; NILOTINIB; UNCLASSIFIED DRUG; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; EVENT FREE SURVIVAL; FOLLOW UP; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; MULTICENTER STUDY (TOPIC); OPEN STUDY; PATIENT COMPLIANCE; PHASE 2 CLINICAL TRIAL (TOPIC); PHILADELPHIA 1 CHROMOSOME; PREDICTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT RESPONSE; CHRONIC DISEASE; DRUG RESISTANCE; GENETICS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MORTALITY; PROGNOSIS; SURVIVAL RATE; THEORETICAL MODEL;

CHRONIC DISEASE; DRUG RESISTANCE, NEOPLASM; FOLLOW-UP STUDIES; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MODELS, THEORETICAL; PROGNOSIS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SURVIVAL RATE;

EID: 84875547971     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-173     Document Type: Article

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