Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a peptide bond

Angewandte Chemie - International Edition

Volumn 50, Issue 44, 2011, Pages 10357-10360

  Arolas, Joan L ^a   Botelho, Tiago O ^a   Vilcinskas, Andreas ^b   Gomis Rüth, F Xavier ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

enzymes; metallopeptidases; protein inhibitors; structure elucidation; thermolysin

Indexed keywords

METALLOPEPTIDASES; METALLOPROTEINASES; MICHAELIS COMPLEX; PEPTIDE BONDS; PROTEIN INHIBITORS; STRUCTURAL EVIDENCE; STRUCTURE ELUCIDATION; THERMOLYSIN; TWO-PRODUCT;

ENZYME INHIBITION; PEPTIDES;

CRYSTAL STRUCTURE;

ENZYME INHIBITOR; INSECT PROTEIN; PEPTIDE; RECOMBINANT PROTEIN; THERMOLYSIN;

ANIMAL; ARTICLE; BACILLUS; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; METABOLISM; MOTH;

ANIMALS; BACILLUS; ENZYME INHIBITORS; INSECT PROTEINS; MOTHS; PEPTIDES; RECOMBINANT PROTEINS; THERMOLYSIN;

EID: 80054974237     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201103262     Document Type: Article

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