-
1
-
-
0000251781
-
The Clomethiazole Acute Stroke Study (CLASS): Efficacy results in 545 patients classified as Total Anterior Circulation Syndrome (TACS)
-
Wahlgren NG, Bornhov S, Sharma A, Cederin B, Rosolacci T, Ashwood T, et al.The Clomethiazole Acute Stroke Study (CLASS): Efficacy results in 545 patients classified as Total Anterior Circulation Syndrome (TACS). Journal of Stroke and Cerebrovascular Diseases 1999;8:231-9.
-
(1999)
Journal of Stroke and Cerebrovascular Diseases
, vol.8
, pp. 231-239
-
-
Wahlgren, N.G.1
Bornhov, S.2
Sharma, A.3
Cederin, B.4
Rosolacci, T.5
Ashwood, T.6
-
2
-
-
0033971797
-
Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients
-
Wahlgren NG, Diez-Tejador E, Teitelbaum J, Arboix A, Leys D, Ashwood T, et al.Results in 95 hemorrhagic stroke patients included in CLASS, a controlled trial of clomethiazole versus placebo in acute stroke patients. Stroke 2000;31:82-5.
-
(2000)
Stroke
, vol.31
, pp. 82-85
-
-
Wahlgren, N.G.1
Diez-Tejador, E.2
Teitelbaum, J.3
Arboix, A.4
Leys, D.5
Ashwood, T.6
-
3
-
-
0034235666
-
The Clomethiazole Acute Stroke Study (CLASS): safety results in 1,356 patients with acute hemispheric stroke
-
Wahlgren NG, Matias Guiu J, Lainez JM, Veloso F, Ranasinha K, Grossman E, et al.The Clomethiazole Acute Stroke Study (CLASS): safety results in 1, 356 patients with acute hemispheric stroke. Journal of Stroke and Cerebrovascular Diseases 2000;9:158-65.
-
(2000)
Journal of Stroke and Cerebrovascular Diseases
, vol.9
, pp. 158-165
-
-
Wahlgren, N.G.1
Matias Guiu, J.2
Lainez, J.M.3
Veloso, F.4
Ranasinha, K.5
Grossman, E.6
-
4
-
-
0032953495
-
Clomethiazole acute stroke study (CLASS). Results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients
-
Wahlgren NG, Ranasinha KW, Rosolacci T, Franke CL, van Erven PMM, Ashwood T, et al.Clomethiazole acute stroke study (CLASS). Results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients. Stroke 1999;30:21-8.
-
(1999)
Stroke
, vol.30
, pp. 21-28
-
-
Wahlgren, N.G.1
Ranasinha, K.W.2
Rosolacci, T.3
Franke, C.L.4
van Erven, P.M.M.5
Ashwood, T.6
-
5
-
-
0033653370
-
The Clomethiazole Acute Stroke Study in Hemorrhagic Stroke (CLASS-H): final results
-
Lyden PD, Shuaib A, Ng K, Atkinson R, Ashwood T, Nordlund A, et al.The Clomethiazole Acute Stroke Study in Hemorrhagic Stroke (CLASS-H): final results. Journal of Stroke and Cerebrovascular Diseases 2000;9:268-75.
-
(2000)
Journal of Stroke and Cerebrovascular Diseases
, vol.9
, pp. 268-275
-
-
Lyden, P.D.1
Shuaib, A.2
Ng, K.3
Atkinson, R.4
Ashwood, T.5
Nordlund, A.6
-
6
-
-
18244392468
-
Clomethiazole acute stroke study in ischemic stroke (CLASS-I)
-
Lyden P, Shuaib A, Levin K, Atkinson RP, Rajput A, Wechsler L, et al.Clomethiazole acute stroke study in ischemic stroke (CLASS-I). Stroke 2002;33:122-9.
-
(2002)
Stroke
, vol.33
, pp. 122-129
-
-
Lyden, P.1
Shuaib, A.2
Levin, K.3
Atkinson, R.P.4
Rajput, A.5
Wechsler, L.6
-
7
-
-
0035833953
-
The clomethiazole acute stroke study in tissue-type plasminogen activator-treated stroke (CLASS-T)
-
Lyden P, Jacoby M, Schim J, Albers G, Mazzeo P, Ashwood T, et al.The clomethiazole acute stroke study in tissue-type plasminogen activator-treated stroke (CLASS-T). Neurology 2001;57:1199-205.
-
(2001)
Neurology
, vol.57
, pp. 1199-1205
-
-
Lyden, P.1
Jacoby, M.2
Schim, J.3
Albers, G.4
Mazzeo, P.5
Ashwood, T.6
-
8
-
-
30944463969
-
Diazepam to improve acute stroke outcome: results of the early GABA-ergic activation study in stroke trial. A randomized double-blind placebo controlled trial
-
Lodder J, van Raak L, Hilton A, Hardy E, Kessels A. Diazepam to improve acute stroke outcome: results of the early GABA-ergic activation study in stroke trial. A randomized double-blind placebo controlled trial. Cerebrovascular Diseases 2006;21:120-7.
-
(2006)
Cerebrovascular Diseases
, vol.21
, pp. 120-127
-
-
Lodder, J.1
van Raak, L.2
Hilton, A.3
Hardy, E.4
Kessels, A.5
-
9
-
-
0038141716
-
Lack of hemispheric dominance for consciousness in acute ischaemic stroke
-
Cucchiara B, Kasner SE, Wolk DA, Lyden PD, Knappertz VA, Ashwood T, et al.Lack of hemispheric dominance for consciousness in acute ischaemic stroke. Journal of Neurology, Neurosurgery and Psychiatry 2003;74:889-92.
-
(2003)
Journal of Neurology, Neurosurgery and Psychiatry
, vol.74
, pp. 889-892
-
-
Cucchiara, B.1
Kasner, S.E.2
Wolk, D.A.3
Lyden, P.D.4
Knappertz, V.A.5
Ashwood, T.6
-
10
-
-
1642574315
-
Early impairment in consciousness predicts mortality after hemispheric ischemic stroke
-
Cucchiara BL, Kasner SE, Wolk DA, Lyden PD, Knappertz VA, Ashwood T, et al.Early impairment in consciousness predicts mortality after hemispheric ischemic stroke. Critical Care Medicine 2004;32:241-5.
-
(2004)
Critical Care Medicine
, vol.32
, pp. 241-245
-
-
Cucchiara, B.L.1
Kasner, S.E.2
Wolk, D.A.3
Lyden, P.D.4
Knappertz, V.A.5
Ashwood, T.6
-
11
-
-
0033773007
-
Diazepam treatment to increase the cerebral GABAergic activity in acute stroke: a feasibility study in 104 patients
-
Lodder J, Luijckx GJ, van Raak L, Kessels F. Diazepam treatment to increase the cerebral GABAergic activity in acute stroke: a feasibility study in 104 patients. Cerebrovascular Diseases 2000;10:437-40.
-
(2000)
Cerebrovascular Diseases
, vol.10
, pp. 437-440
-
-
Lodder, J.1
Luijckx, G.J.2
van Raak, L.3
Kessels, F.4
-
12
-
-
0000450747
-
The clomethiazole acute stroke study in ischemic, hemorrhagic, and t-PA treated stroke: design of a phase III trial in the United States and Canada
-
Lyden PD, Ashwood T, Claesson L, Odergren T, Friday GH, Martin-Munley S. The clomethiazole acute stroke study in ischemic, hemorrhagic, and t-PA treated stroke: design of a phase III trial in the United States and Canada. Journal of Stroke and Cerebrovascular Diseases 1998;7:435-41.
-
(1998)
Journal of Stroke and Cerebrovascular Diseases
, vol.7
, pp. 435-441
-
-
Lyden, P.D.1
Ashwood, T.2
Claesson, L.3
Odergren, T.4
Friday, G.H.5
Martin-Munley, S.6
-
13
-
-
7744235656
-
Factor analysis of the National Institutes of Health Stroke Scale in patients with large strokes
-
Lyden P, Claesson L, Havstad S, Ashwood T, Lu M. Factor analysis of the National Institutes of Health Stroke Scale in patients with large strokes. Archives of Neurology 2004;61:1677-80.
-
(2004)
Archives of Neurology
, vol.61
, pp. 1677-1680
-
-
Lyden, P.1
Claesson, L.2
Havstad, S.3
Ashwood, T.4
Lu, M.5
-
14
-
-
33847126051
-
Measurement properties of the National Institutes of Health Stroke Scale for people with right- and left-hemisphere lesions: further analysis of the clomethiazole for acute stroke study-ischemic (class-I) trial
-
Millis SR, Straube D, Iramaneerat C, Smith EV Jr, Lyden P. Measurement properties of the National Institutes of Health Stroke Scale for people with right- and left-hemisphere lesions: further analysis of the clomethiazole for acute stroke study-ischemic (class-I) trial. Archives of Physical Medicine and Rehabilitation 2007;88:302-8.
-
(2007)
Archives of Physical Medicine and Rehabilitation
, vol.88
, pp. 302-308
-
-
Millis, S.R.1
Straube, D.2
Iramaneerat, C.3
Smith, E.V.4
Lyden, P.5
-
15
-
-
0036173412
-
Implementing the EGASIS trial, an international multicenter acute intervention trial in stroke
-
van Raak L, Hilton A, Kessels F, Lodder J. Implementing the EGASIS trial, an international multicenter acute intervention trial in stroke. Controlled Clinical Trials 2002;23:74-9.
-
(2002)
Controlled Clinical Trials
, vol.23
, pp. 74-79
-
-
van Raak, L.1
Hilton, A.2
Kessels, F.3
Lodder, J.4
-
16
-
-
0031923216
-
An open study of clomethiazole in patients with acute cerebral infarction
-
Wester P, Strand T, Wahlgren NG, Ashwood T, Osswald G. An open study of clomethiazole in patients with acute cerebral infarction. Cerebrovascular Diseases 1998;8:188-90.
-
(1998)
Cerebrovascular Diseases
, vol.8
, pp. 188-190
-
-
Wester, P.1
Strand, T.2
Wahlgren, N.G.3
Ashwood, T.4
Osswald, G.5
-
18
-
-
0028971634
-
Rapid down-regulation of GABAA receptors in the gerbil hippocampus following transient cerebral ischemia
-
Alicke B, Schwartz-Bloom RD. Rapid down-regulation of GABAA receptors in the gerbil hippocampus following transient cerebral ischemia. Journal of Neurochemistry 1995;65:2808-11.
-
(1995)
Journal of Neurochemistry
, vol.65
, pp. 2808-2811
-
-
Alicke, B.1
Schwartz-Bloom, R.D.2
-
19
-
-
0035225668
-
Tirilazad for acute ischemic stroke
-
Bath PM, Iddenden R, Bath FJ, Orgogozo JM, Tirilazad International Steering Committee. Tirilazad for acute ischemic stroke. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD002087]
-
(2001)
Cochrane Database of Systematic Reviews
, Issue.4
-
-
Bath, P.M.1
Iddenden, R.2
Bath, F.J.3
Orgogozo, J.M.4
-
20
-
-
37349081567
-
Pentoxifylline, propentofylline and pentifylline for acute ischemic stroke
-
Bath PMW, Bath-Hextall FJ. Pentoxifylline, propentofylline and pentifylline for acute ischemic stroke. Cochrane Database of Systematic Reviews 2004, Issue 3. [DOI: 10.1002/14651858.CD000162.pub2]
-
(2004)
Cochrane Database of Systematic Reviews
, Issue.3
-
-
Bath, P.M.W.1
Bath-Hextall, F.J.2
-
22
-
-
78751591520
-
Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia
-
Chi OZ, Hunter C, Liu X, Chi Y, Weiss HR. Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia. Journal of Neurological Sciences 2011;301:66-70.
-
(2011)
Journal of Neurological Sciences
, vol.301
, pp. 66-70
-
-
Chi, O.Z.1
Hunter, C.2
Liu, X.3
Chi, Y.4
Weiss, H.R.5
-
23
-
-
84990055032
-
Ischemic stroke in emergency medicine
-
(accessed 9 June 2011)
-
Cruz-Flores S. Ischemic stroke in emergency medicine. http://emedicine.medscape.com/article/1916852-overview (accessed 9 June 2011).
-
-
-
Cruz-Flores, S.1
-
24
-
-
0030922816
-
Bias in meta-analysis detected by a simple graphical test
-
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple graphical test. BMJ 1997;315:629-34.
-
(1997)
BMJ
, vol.315
, pp. 629-634
-
-
Egger, M.1
Davey Smith, G.2
Schneider, M.3
Minder, C.4
-
27
-
-
0042894154
-
Prediction of worsening consciousness from edema after hemispheric infarction
-
Hanna JP, Frank JI, Furlan AJ, Sila SA, Secic S. Prediction of worsening consciousness from edema after hemispheric infarction. Journal of Stroke and Cerebrovascular Diseases 1996;6:25-9.
-
(1996)
Journal of Stroke and Cerebrovascular Diseases
, vol.6
, pp. 25-29
-
-
Hanna, J.P.1
Frank, J.I.2
Furlan, A.J.3
Sila, S.A.4
Secic, S.5
-
28
-
-
84887346660
-
Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]
-
Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
-
(2008)
The Cochrane Collaboration
-
-
Higgins, J.P.T.1
Green, S.2
-
30
-
-
79957446913
-
Therapeutic hypothermia in acute stroke
-
Klassman L. Therapeutic hypothermia in acute stroke. Journal of Neuroscience Nursing 2011;43:94-103.
-
(2011)
Journal of Neuroscience Nursing
, vol.43
, pp. 94-103
-
-
Klassman, L.1
-
31
-
-
0242501513
-
Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures
-
Marshall JW, Green AR, Ridley RM. Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures. Brain Research 2003;972:119-26.
-
(2003)
Brain Research
, vol.972
, pp. 119-126
-
-
Marshall, J.W.1
Green, A.R.2
Ridley, R.M.3
-
33
-
-
0033939414
-
On the regulation of ischemia-induced glutamate efflux from rat cortex by GABA: in vitro studies with GABA, clomethiazole and pentobarbitone
-
Nelson RM, Green AR, Lambert DG, Hainsworth AH. On the regulation of ischemia-induced glutamate efflux from rat cortex by GABA: in vitro studies with GABA, clomethiazole and pentobarbitone. British Journal of Pharmacology 2000;130:1124-30.
-
(2000)
British Journal of Pharmacology
, vol.130
, pp. 1124-1130
-
-
Nelson, R.M.1
Green, A.R.2
Lambert, D.G.3
Hainsworth, A.H.4
-
34
-
-
79960705415
-
Review Manager (RevMan)
-
5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration,
-
The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
-
(2011)
-
-
-
37
-
-
0032796473
-
Use of the Barthel index and modified Rankin scale in acute stroke trials
-
Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke trials. Stroke 1999;30:1538-41.
-
(1999)
Stroke
, vol.30
, pp. 1538-1541
-
-
Sulter, G.1
Steen, C.2
De Keyser, J.3
-
38
-
-
0036152938
-
Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat: studies on dose, plasma concentration and therapeutic time window
-
Sydserff SG, Borelli AR, Green AR, Cross AJ. Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat: studies on dose, plasma concentration and therapeutic time window. British Journal of Pharmacology 2002;135:103-12.
-
(2002)
British Journal of Pharmacology
, vol.135
, pp. 103-112
-
-
Sydserff, S.G.1
Borelli, A.R.2
Green, A.R.3
Cross, A.J.4
-
39
-
-
74249111108
-
Neuron protection as a therapeutic target in acute ischemic stroke
-
Tuttolomondo A, Di Sciacca R, Di Raimondo D, Arnao V, Renda C, Pinto A, et al.Neuron protection as a therapeutic target in acute ischemic stroke. Current Topics in Medicinal Chemistry 2009;9:1317-34.
-
(2009)
Current Topics in Medicinal Chemistry
, vol.9
, pp. 1317-1334
-
-
Tuttolomondo, A.1
Di Sciacca, R.2
Di Raimondo, D.3
Arnao, V.4
Renda, C.5
Pinto, A.6
-
41
-
-
17444395592
-
Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat
-
Visser SA, Pozarek S, Martinsson S, Forsberg T, Ross SB, Gabrielsson J. Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat. European Journal of Pharmacology 2005;512:139-51.
-
(2005)
European Journal of Pharmacology
, vol.512
, pp. 139-151
-
-
Visser, S.A.1
Pozarek, S.2
Martinsson, S.3
Forsberg, T.4
Ross, S.B.5
Gabrielsson, J.6
-
42
-
-
0000035077
-
What caused this transient or persistent ischemic event?
-
2nd Edition. Oxford: Wiley-Blackwell,
-
Warlow CP, Dennis MS, van Gijn J, Hankey GJ, Sandercock PAG, Bamford JM, et al.What caused this transient or persistent ischemic event?. Stroke: A Practical Guide to Management. 2nd Edition. Oxford: Wiley-Blackwell, 2001.
-
(2001)
Stroke: A Practical Guide to Management
-
-
Warlow, C.P.1
Dennis, M.S.2
van Gijn, J.3
Hankey, G.J.4
Sandercock, P.A.G.5
Bamford, J.M.6
-
43
-
-
14844337377
-
The atlas of heart disease and stroke
-
(accessed 9 June 2011)
-
World Health Organization. The atlas of heart disease and stroke. http://www.who.int/cardiovascular_diseases/resources/atlas/en (accessed 9 June 2011).
-
-
-
-
44
-
-
12344333481
-
The pharmacology of chlormethiazole: a potential neuroprotective agent?
-
Wilby MJ, Hutchinson PJ. The pharmacology of chlormethiazole: a potential neuroprotective agent?. CNS Drug Reviews 2004;10:281-94.
-
(2004)
CNS Drug Reviews
, vol.10
, pp. 281-294
-
-
Wilby, M.J.1
Hutchinson, P.J.2
-
45
-
-
0042530229
-
Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients
-
Zingmark PH, Ekblom M, Odergren T, Ashwood T, Lyden P, Karlsson MO, et al.Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients. British Journal of Clinical Pharmacology 2003;56:173-83.
-
(2003)
British Journal of Clinical Pharmacology
, vol.56
, pp. 173-183
-
-
Zingmark, P.H.1
Ekblom, M.2
Odergren, T.3
Ashwood, T.4
Lyden, P.5
Karlsson, M.O.6
-
46
-
-
77955836016
-
Role of GABAergic neurons in the nucleus tractus solitarii in modulation of cardiovascular activity
-
Zubcevic J, Potts JT. Role of GABAergic neurons in the nucleus tractus solitarii in modulation of cardiovascular activity. Experimental Physiology 2010;95:909-18.
-
(2010)
Experimental Physiology
, vol.95
, pp. 909-918
-
-
Zubcevic, J.1
Potts, J.T.2
-
47
-
-
84875498712
-
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke
-
Liu J, Wang L. Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. Cochrane Database of Systematic Reviews 2012, Issue 2. [DOI: 10.1002/14651858.CD009622]
-
(2012)
Cochrane Database of Systematic Reviews
, Issue.2
-
-
Liu, J.1
Wang, L.2
|