Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells

Molecular Cancer Research

Volumn 11, Issue 3, 2013, Pages 294-302

  Li, Xuqi ^a   Ma, Guodong ^a   Ma, Qingyong ^a   Li, Wei ^a   Liu, Jiangbo ^a   Han, Liang ^a   Duan, Wanxing ^a   Xu, Qinhong ^a   Liu, Han ^a   Wang, Zheng ^a   Sun, Qing ^a   Wang, Fengfei ^b   Wu, Erxi ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; GELATINASE A; MATRIGEL; SUBSTANCE P; SUBSTANCE P RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CANCER PAIN; CELL ASSAY; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; NERVE FIBER GROWTH; NEUROTROPISM; NEWBORN; NONHUMAN; PANCREAS CANCER; PERINEURIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; GANGLIA, SPINAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEUROKININ-1 RECEPTOR ANTAGONISTS; PANCREATIC NEOPLASMS; RATS; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; SUBSTANCE P;

AGOUTI PACA;

EID: 84875475728     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0609     Document Type: Article

References (31)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
2. Pour PM, Bell RH, Batra SK. Neural invasion in the staging of pancreatic cancer. Pancreas 2003;26:322-5. (Pubitemid 36529955)
3. Beger HG, Rau B, Gansauge F, Poch B, Link KH. Treatment of pancreatic cancer: challenge of the facts. World J Surg 2003;27:1075-84. (Pubitemid 37259985)
4. Zielinska D, Durlik M. Quality of life in patiens after pancreas resection - review paper. Przeglad Gastroenterologiczny 2010;5:83-7.
5. di Mola FF, di Sebastiano P. Pain and pain generation in pancreatic cancer. Langenbecks Arch Surg 2008;393:919-22.
6. Hokfelt T, Pernow B, Wahren J. Substance P: a pioneer amongst neuropeptides. J Intern Med 2001;249:27-40. (Pubitemid 32147090)
7. Esteban F, Munoz M, Gonzalez-Moles MA, Rosso M. A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metastasis Rev 2006;25:137-45. (Pubitemid 43723988)
8. Marriott I, Bost KL. IL-4 and IFN-gamma up-regulate substance P receptor expression in murine peritoneal macrophages. J Immunol 2000;165:182-91. (Pubitemid 30429506)
9. Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, et al. Broadspectrum G protein-coupled receptor antagonist, D-Arg(1) D-Trp (5,7,9),Leu(11) SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res 2005;65:2738-45. (Pubitemid 40490075)
10. Munoz M, Rosso M, Covenas R. A new frontier in the treatment of cancer: NK-1 receptor antagonists. Curr Med Chem 2010;17:504-16.
11. Munoz M, Rosso M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest New Drugs 2010;28:187-93.
12. Friess H, Zhu ZW, Liard V, Shi X, Shrikhande SV, Wang L, et al. Neurokinin-1 receptor expression and its potential effects on tumor growth in human pancreatic cancer. Lab Invest 2003;83:731-42. (Pubitemid 36618051)
13. Li J, Ma Q, Liu H, Guo K, Li F, Li W, et al. Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia. PLoS ONE 2011;6:e17385.
14. Liu H, Ma Q, Li J. High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells. Mol Cell Biochem 2011;347:95-101.
15. Li JH, Ma QY, Shen SG, Hu HT. Stimulation of dorsal root ganglion neurons activity by pancreatic cancer cell lines. Cell Biol Int 2008; 32:1530-5.
16. Ceyhan GO, Demir IE, Altintas B, Rauch U, Thiel G, Muller MW, et al. Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells. Biochem Biophys Res Commun 2008; 374:442-7.
17. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402-8. (Pubitemid 34164012)
18. Munoz M, Gonzalez-Ortega A, Covenas R. The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines. Invest New Drugs 2012;30:529-40.
19. Harrison S, Geppetti P. Substance P. Int J Biochem Cell Biol 2001; 33:555-76. (Pubitemid 32510811)
20. Seckl MJ, Higgins T, Widmer F, Rozengurt E. [D-Arg1,D-Trp5,7,9, Leu11]substance P: a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells. Cancer Res 1997;57:51-4. (Pubitemid 27020329)
21. Bigioni M, Benzo A, Irrissuto C, Maggi CA, Goso C. Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231. Anticancer Drugs 2005;16:1083-9. (Pubitemid 41565774)
22. Luo W, Sharif TR, Sharif M. Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogenactivated protein kinase signaling pathway. Cancer Res 1996;56:4983-91. (Pubitemid 26374439)
23. Koon HW, Zhao DZ, Na X, Moyer MP, Pothoulakis C. Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem 2004;279:45519-27. (Pubitemid 39491538)
24. Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, Sampson JH, et al. A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J Neurochem 2009;109:1079-86.
25. Entschladen F, Drell TL, Lang K, Joseph J, Zaenker KS. Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 2004;5:254-8. (Pubitemid 38391223)
26. Lang K, Drell TL, Lindecke A, Niggemann B, Kaltschmidt C, Zaenker KS, et al. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 2004;112:231-8. (Pubitemid 39244363)
27. di Mola FF, Di Sebastiano P. Pain and pain generation in pancreatic diseases. Am J Surg 2007;194:S65-70. (Pubitemid 47445384)
28. Munoz M, Rosso M, Gonzalez A, Saenz J, Covenas R. The broadspectrum antitumor action of cyclosporin A is due to its tachykinin receptor antagonist pharmacological profile. Peptides 2010;31:1643-8.
29. Rupniak NM, Carlson E, Boyce S, Webb JK, Hill RG. Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils. Pain 1996;67:189-95. (Pubitemid 26319652)
30. Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 1998;281:1640-5. (Pubitemid 28435572)
31. Yu J, Cadet JL, Angulo JA. Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J Neurochem 2002;83:613-22. (Pubitemid 35231815)