Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivity

Journal of Biological Chemistry

Volumn 288, Issue 12, 2013, Pages 8772-8784

  Kulkarni, Manjusha M ^a   Karafova, Anna ^b   Kamysz, Wojciech ^b   Schenkman, Sergio ^c   Pelle, Roger ^d   McGwire, Bradford S ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL PEPTIDE; GASTROINTESTINAL TRACT; METABOLIC RESPONSE; MOLECULAR SENSORS; PEPTIDYL-PROLYL ISOMERASE; PHOSPHATASE ACTIVITY; PROLINE RESIDUES; TRYPANOSOMA CRUZI;

DRUG PRODUCTS; METABOLISM; PEPTIDES; POLYPEPTIDES;

ENZYME ACTIVITY;

ADENOSINE TRIPHOSPHATE; CALCINEURIN; CYCLOPHILIN; CYCLOSPORIN A; OXIDOREDUCTASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE; TACROLIMUS; TRIALYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL INVASION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIMASTIGOTE; HOST PARASITE INTERACTION; LEISHMANIA; LEISHMANIA MAJOR; MYOBLAST; NONHUMAN; PARASITE SURVIVAL; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REDUVIIDAE; TRYPANOSOMA CRUZI;

ADAPTATION, BIOLOGICAL; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CALCINEURIN; CELL LINE; CYCLOPHILINS; ENERGY METABOLISM; ENZYME ACTIVATION; HOST-PARASITE INTERACTIONS; IMMUNE EVASION; LEISHMANIA; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; PROLINE; PROTOZOAN PROTEINS; RATS; SALIVARY PROTEINS AND PEPTIDES; SIGNAL TRANSDUCTION; TRYPANOSOMA CRUZI;

HEXAPODA; PROTOZOA; REDUVIIDAE; TRYPANOSOMA CRUZI;

EID: 84875472353     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.421057     Document Type: Article

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