Plasma Aβ: A possible missing link between alzheimer disease and diabetes

Diabetes

Volumn 62, Issue 4, 2013, Pages 1005-1006

  Sato, Naoyuki ^a   Morishita, Ryuichi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; GLUCOSE; INSULIN; JANUS KINASE 2; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1;

ALZHEIMER DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMAN; INSULIN RESISTANCE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; UPREGULATION;

AMYLOID BETA-PEPTIDES; ANIMALS; INSULIN RESISTANCE; JANUS KINASE 2; MALE;

EID: 84875468297     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1549     Document Type: Note

References (22)

1. Dartigues JF. Alzheimer's disease: a global challenge for the 21st century. Lancet Neurol 2009;8:1082-1083
2. Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991;349:704-706
3. Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375:754-760
4. Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 1999;53:1937-1942
5. Type 2 diabetes epidemic: a global education. Lancet 2009;374:1654
6. Bucht G, Adolfsson R, Lithner F, Winblad B. Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type. Acta Med Scand 1983;213:387-392
7. Meneilly GS, Hill A. Alterations in glucose metabolism in patients with Alzheimer's disease. J Am Geriatr Soc 1993;41:710-714
8. Takeda S, Sato N, Uchio-Yamada K, et al. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci USA 2010;107: 7036-7041
9. Sato N, Takeda S, Uchio-Yamada K, et al. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Curr Aging Sci 2011;4:118-127
10. van de Nes JA, Kamphorst W, Ravid R, Swaab DF. Comparison of betaprotein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: amorphic plaques and cytoskeletal changes occur independently. Acta Neuropathol 1998;96:129-138
11. Miklossy J, Qing H, Radenovic A, et al. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging 2008;31:1503-1515
12. Roher AE, Esh CL, Kokjohn TA, et al. Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease. Alzheimers Dement 2009;5:18-29
13. Gasparini L, Gouras GK, Wang R, et al. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 2001; 21:2561-2570
14. Qiu WQ, Walsh DM, Ye Z, et al. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem 1998;273:32730-32738
15. Takeda S, Sato N, Uchio-Yamada K, et al. Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models. Biochem Biophys Res Commun 2009;385:193-197
16. Takeda S, Sato N, Uchio-Yamada K, et al. Oral glucose loading modulates plasma b-amyloid level in Alzheimer's disease patients: potential diagnostic method for Alzheimer's disease. Dement Geriatr Cogn Disord 2012;34:25-30
17. Kulstad JJ, Green PS, Cook DG, et al. Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease. Neurology 2006;66:1506-1510
18. Zhang Y, Zhou B, Zhang F, et al. Amyloid-b induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 2012;61:1434-1443
19. Zhang Y, Zhou B, Deng B, et al. Amyloid-b induces hepatic insulin resistance in vivo via JAK2. Diabetes 2013;62:1159-1166
20. Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000;19:2548-2556
21. Tokutake T, Kasuga K, Yajima R, et al. Hyperphosphorylation of tau induced by naturally secreted amyloid-b at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3b signaling pathway. J Biol Chem 2012;287:35222-35233
22. Iwatsubo T. Amyloid beta protein in plasma as a diagnostic marker for Alzheimer's disease. Neurobiol Aging 1998;19:161-163