Differential nuclear factor-kappa B phosphorylation induced by lipopolysaccharide in the hippocampus of P2x7 receptor knockout mouse

Neurological Research

Volumn 35, Issue 4, 2013, Pages 369-381

  Kim, Won Il ^a   Ryu, Hea Jin ^a   Kim, Ji Eun ^a   Seo, Cheong Hoon ^a   Lee, Boung Chul ^a   Choi, Ihn Geun ^a   Kang, Tae Cheon ^a  

^a Hallym University   (South Korea)

Author keywords

LPS; Neuronal damage; NF kappaB; P2x7 knockout mouse; Phosphorylation

Indexed keywords

CD11B ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN P52; PURINERGIC P2X7 RECEPTOR; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KNOCKOUT MOUSE; MALE; MICROGLIA; MOUSE; NERVE INJURY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; NF-KAPPA B; PHOSPHORYLATION; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84875462407     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132812Y.0000000137     Document Type: Article

References (39)

1. Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428-35.
2. McGeer PL, McGeer EG. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Dis Assoc Disord. 1998;12:S1-6.
3. Lue LF, Rydel R, Brigham EF, Yang L, Hampel H, Murphy GM, et al. Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia. 2001;35:72-9.
4. Walker DG, Lue LF, Beach TG. Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiol Aging. 2001;22:957-66.
5. Gibertini M. Cytokines and cognitive behavior. Neuroimmunomodulation. 1998;5:160-5.
6. Turnbull AV, Rivier CL. Sprague-Dawley rats obtained from different vendors exhibit distinct adrenocorticotropin responses to inflammatory stimuli. Neuroendocrinology. 1999;70:186-95.
7. Leon RL. Hazards in opportunity. J Immigr Health. 2002; 4:111-5.
8. Opp MR. Cytokines and sleep. Sleep Med Rev. 2005;9:355-64
9. Dantzer R. Cytokine, sickness behavior, and depression. Neurol Clin. 2006;24:441-60.
10. Toth LA, Opp MR. Cytokine and microbially induced sleep responses of interleukin-10 deficient mice. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1806-14.
11. Thomas JA, Tsen MF, White DJ, Horton JW. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol. 2002;283:H1645-55.
12. Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem. 2002;81:1285-97.
13. Gibbons HM, Dragunow M. Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain Res. 2006;1084:1-15.
14. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066-71.
15. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;10:725-34.
16. Tartaglia LA, Goeddel DV. Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor. J Biol Chem. 1992;267:4304-7.
17. Rothwarf DM, Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE. 1999;1999:RE1.
18. Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci. 2005;30:43-52.
19. 2z in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am J Physiol Cell Physiol. 2003;285:C286-99.
20. Witting A, Walter L, Wacker J, Moller T, Stella N. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells. Proc Natl Acad Sci USA. 2004;101:3214-9
21. Bernardino L, Balosso S, Ravizza T, Marchi N, Ku G, Randle JC, et al. Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release. J Neurochem. 2008;106:271-80.
22. Ferrari D, Chiozzi P, Falzoni S, Hanau S, Di Virgilio F. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp. 1997;185:579-82.
23. Mingam R, De Smedt V, Amedee T, Bluthe RM, Kelley KW, Dantzer R, et al. In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain. Brain Behav. 2008;22:234-44.
24. Ryu HJ, Kim JE, Yeo SI, Kim MJ, Jo SM, Kang TC. ReLA/ P65-serine 536 nuclear factor-kappa B phosphorylation is related to vulnerability to status epilepticus in the rat hippocampus. Neuroscience. 2011;187:93-102.
25. Ryu HJ, Kim JE, Yeo SI, Kang TC. p65/RelA-Ser529 NF-kB subunit phosphorylation induces autophagic astroglial death (Clasmatodendrosis) following status epilepticus. Cell Mol Neurobiol. 2011;31:1071-8.
26. Bito H, Takemoto-Kimura S. Retinoic acid induces apoptosis in PC12 cells independent of neurotrophic factors. J Neurochem. 1997;68:1424-35.
27. Contestabile A. Regulation of transcription factors by nitric oxide in neurons and in neural-derived tumor cells. Prog Neurobiol. 2008;84:317-28.
28. Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell. 2002;9:625-36.
29. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen and stress-activated protein kinase-1 (MSK1). EMBO J. 2003;22:1313-24.
30. Duran A, Diaz-Meco MT, Moscat J. Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcripttional activation. EMBO J. 2003;22:3910-8.
31. Czapski GA, Gajkowska B, Strosznajder JB. Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus. Brain Res. 2010;1356:85-94.
32. Milatovic D, Zaja-Milatovic S, Montine KS, Horner PJ, Montine TJ. Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. J Neurochem. 2003;87:1518-26.
33. Viatour P, Bentires-Alj M, Chariot A, Deregowski V, de Leval L, Merville MP, et al. NF-kappa B2/p100 induces Bcl-2 expression. Leukemia. 2003;17:1349-56.
34. Wang D, Westerheide SD, Hanson JL, Baldwin AS Jr. Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J Biol Chem. 2000;275:32592-7.
35. Xiao M, Inal CE, Parekh VI, Li XH, Whitnall MH. Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury. Exp Hematol. 2009;37:52-64.
36. Kahlenberg JM, Lundberg KC, Kertesy SB, Qu Y, Dubyak GR. Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol. 2005;175:7611-22.
37. Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL. Purinergic signaling is required for fluid shear stress-induced NF-kB translocation in osteoblasts. Exp Cell Res. 2011; 317:737-44.
38. Korcok J, Raimundo LN, Ke HZ, Sims SM, Dixon SJ. Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts. J Bone Miner Res. 2004;19:642-51.
39. von Albertini M, Palmetshofer A, Kaczmarek E, Koziak K, Stroka D, Grey ST, et al. Extracellular ATP and ADP activate transcription factor NF-kappa B and induce endothelial cell apoptosis. Biochem Biophys Res Commun. 1998;248:822-9.