Mild passive focal cooling prevents epileptic seizures after head injury in rats

Annals of Neurology

Volumn 73, Issue 2, 2013, Pages 199-209

  D'Ambrosio, Raimondo ^a,b   Eastman, Clifford L ^a   Darvas, Felix ^a   Fender, Jason S ^a   Verley, Derek R ^a,f   Farin, Federico M ^a,b   Wilkerson, Hui Wen ^a,b   Temkin, Nancy R ^a,c   Miller, John W ^a   Ojemann, Jeffrey ^a,b   Rothman, Steven M ^d,g   Smyth, Matthew D ^e  

^a Department of Neurological Surgery ^*  (United States)

^b Center for Human Development and Disability   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e WASHINGTON UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g Mercy Clinic Child Neurology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC SPONTANEOUS RECURRENT SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; ELECTROCORTICOGRAPHY; GENE EXPRESSION; HEAD INJURY; INDUCED HYPOTHERMIA; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SEIZURE;

ACRYLATES; ANIMALS; CRANIOCEREBRAL TRAUMA; DISEASE MODELS, ANIMAL; EPILEPSY; EQUIPMENT DESIGN; HEAD PROTECTIVE DEVICES; HYPOTHERMIA, INDUCED; MALE; NEOCORTEX; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STEEL;

EID: 84875458417     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23764     Document Type: Article

References (48)

1. Agrawal A, Timothy J, Pandit L, Manju M,. Post-traumatic epilepsy: an overview. Clin Neurol Neurosurg 2006; 108: 433-439.
2. Frey LC,. Epidemiology of posttraumatic epilepsy: a critical review. Epilepsia 2003; 44 (suppl 10): 11-17.
3. Eftekhar B, Sahraian MA, Nouralishahi B, et al. Prognostic factors in the persistence of posttraumatic epilepsy after penetrating head injuries sustained in war. J Neurosurg 2009; 110: 319-326.
4. Semah F, Picot MC, Adam C, et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology 1998; 51: 1256-1262.
5. Lu Y, Yu W, Wang X,. Efficacy of topiramate in adult patients with symptomatic epilepsy: an open-label, long-term, retrospective observation. CNS Drugs 2009; 23: 351-359.
6. Temkin NR,. Preventing and treating posttraumatic seizures: the human experience. Epilepsia 2009; 50 (suppl 2): 10-13.
7. Lowenstein DH,. Epilepsy after head injury: an overview. Epilepsia 2009; 50 (suppl 2): 4-9.
8. Linares G, Mayer SA,. Hypothermia for the treatment of ischemic and hemorrhagic stroke. Crit Care Med 2009; 37 (7 suppl): S243-S249.
9. Peterson K, Carson S, Carney N,. Hypothermia treatment for traumatic brain injury: a systematic review and meta-analysis. J Neurotrauma 2008; 25: 62-71.
10. Polderman KH,. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med 2009; 37 (7 suppl): S186-S202.
11. Sahuquillo J, Vilalta A,. Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury. Curr Pharm Des 2007; 13: 2310-2322.
12. Rothman SM,. The therapeutic potential of focal cooling for neocortical epilepsy. Neurotherapeutics 2009; 6: 251-257.
13. Burton J, Peebles G, Binder D, et al. Transcortical cooling inhibits hippocampal-kindled seizures in the rat. Epilepsia 2005; 46: 1881-1887.
14. Atkins CM, Truettner JS, Lotocki G, et al. Post-traumatic seizure susceptibility is attenuated by hypothermia therapy. Eur J Neurosci 2010; 32: 1912-1920.
15. Thompson HJ, Lifshitz J, Marklund N, et al. Lateral fluid percussion brain injury: a 15-year review and evaluation. J Neurotrauma 2005; 22: 42-75.
16. D'Ambrosio R, Fairbanks JP, Fender JS, et al. Posttraumatic epilepsy following fluid percussion injury in the rat. Brain 2004; 127: 304-314.
17. D'Ambrosio R, Fender JS, Fairbanks JP, et al. Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the rat. Brain 2005; 128: 174-188.
18. D'Ambrosio R, Hakimian S, Stewart T, et al. Functional definition of seizure provides new insight into post-traumatic epileptogenesis. Brain 2009; 132: 2805-2821.
19. Curia G, Levitt M, Fender JS, et al. Impact of injury location and severity on posttraumatic epilepsy in the rat: role of frontal neocortex. Cereb Cortex 2010; 21: 1574-1592.
20. Williamson PD, Spencer DD, Spencer SS, et al. Complex partial seizures of frontal lobe origin. Ann Neurol 1985; 18: 497-504.
21. Diaz-Arrastia R, Agostini MA, Frol AB, et al. Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults. Arch Neurol 2000; 57: 1611-1616.
22. Bancaud J, Talairach J,. Clinical semiology of frontal lobe seizures. In:, Chauvel P, Delgado-Escueta AV, Halgren E, Bancaud J, eds. Advances in neurology. Vol 57. New York, NY: Raven Press; 1992: 3-58.
23. Eastman CL, Verley DR, Fender JS, et al. ECoG studies of valproate, carbamazepine and halothane in frontal-lobe epilepsy induced by head injury in the rat. Exp Neurol 2010; 224: 369-388.
24. Eastman CL, Verley DR, Fender JS, et al. Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies. J Pharmacol Exp Ther 2011; 336: 779-790.
25. Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3:RESEARCH0034.
26. Fujii M, Inoue T, Nomura S, et al. Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions. Epilepsia 2012; 53: 485-493.
27. Leppik IE., Seizures. In:, Leppik IE, ed. Contemporary diagnosis and management of the patient with epilepsy. Newtown, PA: Handbooks in Health Care, 2006: 9-20.
28. D'Ambrosio R, Miller JW,. What is an epileptic seizure? Unifying definitions in clinical practice and animal research to develop novel treatments. Epilepsy Curr 2010; 10: 61-66; comment 90.
29. D'Ambrosio R, Maris DO, Grady MS, et al. Selective loss of hippocampal long-term potentiation, but not depression, following fluid percussion injury. Brain Res 1998; 786: 64-79.
30. Cohen AS, Pfister BJ, Schwarzbach E, et al. Injury-induced alterations in CNS electrophysiology. Prog Brain Res 2007; 161: 143-169.
31. González-Ibarra FP, Varon J, Lõpez-Meza EG,. Therapeutic hypothermia: critical review of the molecular mechanisms of action. Front Neurol 2011; 2: 4.
32. Norwood BA, Bumanglag AV, Osculati F, et al. Classic hippocampal sclerosis and hippocampal-onset epilepsy produced by a single "cryptic" episode of focal hippocampal excitation in awake rats. J Comp Neurol 2010; 518: 3381-3407.
33. Choi J, Koh S,. Role of brain inflammation in epileptogenesis. Yonsei Med J 2008; 49: 1-18.
34. Vezzani A, French J, Bartfai T, Baram TZ,. The role of inflammation in epilepsy. Nat Rev Neurol 2011; 7: 31-40.
35. Vezzani A, Friedman A, Dingledine RJ,. The role of inflammation in epileptogenesis. Neuropharmacology. Doi:10.1016/j.neuropharm.2012.04.004 [Epub ahead of print].
36. Pitkänen A, Narkilahti S, Bezvenyuk Z, et al. Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats. Epilepsy Res 2004; 61: 119-140.
37. Stover JF, Steiger P, Stocker R,. Controversial issues concerning norepinephrine and intensive care following severe traumatic brain injury. Eur J Trauma 2006; 32: 10-27.
38. Tokutomi T, Miyagi T, Takeuchi Y, et al. Effect of 35 degrees C hypothermia on intracranial pressure and clinical outcome in patients with severe traumatic brain injury. J Trauma 2009; 66: 166-173.
39. Tokutomi T, Morimoto K, Miyagi T, et al. Optimal temperature for the management of severe traumatic brain injury: effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery 2003; 52: 102-111.
40. Dietrich WD, Bramlett HM,. The evidence for hypothermia as a neuroprotectant in traumatic brain injury. Neurotherapeutics 2010; 7: 43-50.
41. Bramlett HM, Green EJ, Dietrich WD, et al. Posttraumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. J Neurotrauma 1995; 12: 289-298.
42. Doll H, Truebel H, Kipfmueller F, et al. Pharyngeal selective brain cooling improves neurofunctional and neurocognitive outcome after fluid percussion brain injury in rats. J Neurotrauma 2009; 26: 235-242.
43. Fox JL, Vu EN, Doyle-Waters M, et al. Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review. CJEM 2010; 12: 355-364.
44. Tolias CM, Bullock MR,. Critical appraisal of neuroprotection trials in head injury: what have we learned? NeuroRx 2004; 1: 71-79.
45. Qiu W, Zhang Y, Sheng H, et al. Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy. J Crit Care 2007; 22: 229-235.
46. Liu WG, Qiu WS, Zhang Y, et al. Effects of selective brain cooling in patients with severe traumatic brain injury: a preliminary study. J Int Med Res 2006; 34: 58-64.
47. Eng LF, Ghirnikar RS,. GFAP and astrogliosis. Brain Pathol 1994; 4: 229-237.
48. Basu A, Krady JK, Levison SW,. Interleukin-1: a master regulator of neuroinflammation. J Neurosci Res 2004; 78: 151-156.