Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions

Epilepsia

Volumn 53, Issue 3, 2012, Pages 485-493

  Fujii, Masami ^a,b   Inoue, Takao ^a,b   Nomura, Sadahiro ^a,b   Maruta, Yuichi ^a,b   He, Yeting ^a,b   Koizumi, Hiroyasu ^a,b   Shirao, Satoshi ^a   Owada, Yuji ^a,b   Kunitsugu, Ichiro ^a   Yamakawa, Toshitaka ^b,c   Tokiwa, Tatsuji ^a,d   Ishizuka, Satoshi ^a,d   Yamakawa, Takeshi ^a,d   Suzuki, Michiyasu ^a,b  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Consortium for Advanced Epilepsy Treatment ^*  (Japan)

^c SHIZUOKA UNIVERSITY   (Japan)

^d KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Epilepsy; Focal brain cooling; Implantable device; Therapeutic temperatures

Indexed keywords

COBALT; PENICILLIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; COOLING; DIFFERENTIATION; ELECTROCORTICOGRAPHY; EPILEPTIC DISCHARGE; EPILEPTIC FOCUS; EPILEPTIC STATE; FOCAL EPILEPSY; FORELIMB; INTEGRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX;

ANIMALS; BODY TEMPERATURE; BRAIN WAVES; COBALT; CONVULSANTS; DISEASE MODELS, ANIMAL; ELECTRONICS, MEDICAL; EPILEPSIES, PARTIAL; EPILEPSY; HYPOTHERMIA, INDUCED; MALE; MOTOR CORTEX; PENICILLIN G; RATS; RATS, WISTAR;

EID: 84862819938     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03388.x     Document Type: Article

References (37)

1. Brinkman J, Colebatch JG, Porter R, York DH,. (1985) Responses of precentral cells during cooling of post-central cortex in conscious monkeys. J Physiol 368: 611-625. (Pubitemid 16192440)
2. Burton JM, Peebles GA, Binder DK, Rothmann SM, Smyth MD,. (2005) Transcortical cooling inhibits hippocampal-kindled seizures in the rat. Epilepsia 46: 1881-1887. (Pubitemid 44921998)
3. Chang JH, Yang X-F, Zempel JM, Rothman SM,. (2004) The unilateral cobalt wire model of neocortical epilepsy: a method of producing subacute focal seizures in rodents. Epilepsy Res 61: 153-160. (Pubitemid 39296706)
4. Clark DL, Colbourne F,. (2007) A simple method to induce focal brain hypothermia in rats. J Cereb Blood Flow Metab 27: 115-122. (Pubitemid 46006589)
5. Corry JJ, Dhar R, Murphy T, Diringer MN,. (2008) Hypothermia for refractory status epilepticus. Neurocrit Care 9: 189-197.
6. Dow RS, Fernandez-Guardiola A, Manni E,. (1962) The production of cobalt experimental epilepsy in the rat. Electroencephalogr Clin Neurophysiol 14: 399-407.
7. Eilers H, Bickler PE,. (1996) Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices. Anesthesiology 85: 600-607. (Pubitemid 26332614)
8. Elger CE, Speckmann E-J,. (1983) Penicillin-induced epileptic foci in the motor cortex: vertical inhibition. Electroencephalogr Clin Neurophysiol 56: 604-622. (Pubitemid 14218277)
9. Fujioka H, Kaneko H, Suzuki SS, Mabuchi K,. (2004) Hyperexcitability- associated rapid plasticity after a focal cerebral ischemia. Stroke 35: e346-348.
10. Fujioka H, Fujii M, Koizumi H, Imoto H, Nomura S, Saito T, Suzuki M,. (2010) An implantable, focal brain cooling device suppresses nociceptive pain in rats. Neurosci Res 66: 402-405.
11. Hall RD, Lindholm EP,. (1974) Organization of motor and somatosensory neocortex in the albino rat. Brain Res 66: 23-38.
12. Hill MW, Wong M, Amarakone A, Rothman SM,. (2000) Rapid cooling aborts seizure-like activity in rodent hippocampal-entorhinal slices. Epilepsia 41: 1241-1248.
13. Hunter AJ, Hatcher J, Virley D, Nelson P, Irving E, Hadingham SJ, Parson AA,. (2000) Functional assessments in mice and rats after focal stroke. Neuropharmacology 39: 806-816. (Pubitemid 30103684)
14. Imoto H, Fujii M, Uchiyama J, Fujisawa H, Nakano K, Kunitsugu I, Nomura S, Saito T, Suzuki M,. (2006) Use of a Peltier chip with a newly devised local brain-cooling system for neocortical seizures in the rat. J Neurosurg 104: 150-156.
15. Javedan SP, Fisher RS, Eder HG, Smyth K, Wu J,. (2002) Cooling abolishes neuronal network synchronization in rat hippocampal slices. Epilepsia 43: 574-580. (Pubitemid 34627715)
16. Karkar KM, Garcia PA, Bateman LM, Smyth MD, Barbaro NM, Berger M,. (2002) Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. Epilepsia 43: 932-935. (Pubitemid 34857872)
17. Lomber SG, Payne BR,. (2004) Cerebral areas mediating visual redirection of gaze: cooling deactivation of 15 loci in the cat. J Comp Neurol 474: 190-208. (Pubitemid 38702682)
18. Lomber SG, Payne BR, Cornwell P,. (1996) Learning and recall of form discriminations during reversible cooling deactivation of ventral-posterior suprasylvian cortex in the cat. Proc Natl Acad Sci USA 93: 1654-1658. (Pubitemid 26075180)
19. Malhotra S, Hall AJ, Lomber SG,. (2004) Cortical control of sound localization in the cat: unilateral cooling deactivation of 19 cerebral areas. J Neurophysiol 92: 1625-1643. (Pubitemid 39100661)
20. McGill JK, Gallagher L, Carswell HV, Irving EA, Dominiczak AF, Macrae IM,. (2005) Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke 36: 135-141. (Pubitemid 40054189)
21. Nolte J,. (2009) Cerebral cortex. In, Nolte J, (Ed.) The human brain, an introduction to its functional anatomy. 6th ed. Mosby Elsevier, Philadelphia, PA, pp. 541-579.
22. Oku T, Fujii M, Tanaka N, Imoto H, Uchiyama J, Oka F, Kunitsugu I, Fujioka H, Nomura S, Kajiwara K, Fujisawa H, Kato S, Saito T, Suzuki M,. (2009) The influence of focal brain cooling on neurophysiopathology: validation for clinical application. J Neurosurg 110: 1209-1217.
23. Ommaya AK, Baldwin M,. (1963) Extravascular local cooling of the brain in man. J Neurosurg 20: 8-20.
24. Reynolds AF, Ojemann GA, Ward AA,. (1975) Intracellular recording during focal hypothermia of penicillin and alumina experimental epileptic foci. Exp Neurol 46: 583-604.
25. Rothman SM,. (2009) The therapeutic potential of focal cooling for neocortical epilepsy. NeuroRx 6: 251-257.
26. Rothman SM, Smyth MD, Yang X-F, Peterson GP,. (2005) Focal cooling for epilepsy: an alternative therapy that might actually work. Epilepsy Behav 7: 214-221. (Pubitemid 41149523)
27. Sartorius CJ, Berger MS,. (1998) Rapid termination of intraoperative stimulation-evoked seizures with application of cold Ringer's lactate to the cortex. J Neurosurg 88: 349-351. (Pubitemid 28063615)
28. Sasaki K, Gemba H,. (1984) Compensatory motor function of the somatosensory cortex for the motor cortex temporarily impaired by cooling in the monkey. Exp Brain Res 55: 60-68. (Pubitemid 14081831)
29. Soblosky JS, Matthews MA, Davidson JF, Tabor SL, Garey ME,. (1996) Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rats: physiological, histological and behavioral correlates. Behav Brain Res 79: 79-92. (Pubitemid 26308928)
30. Sourek K, Travnicek V,. (1970) General and local hypothermia of the brain in the treatment of intractable epilepsy. J Neurosurg 33: 253-259.
31. Stacey WC, Litt B,. (2008) Technology insight: neuroengineering and epilepsy-designing devices for seizure control. Nat Clin Pract Neurol 4: 190-201. (Pubitemid 351516747)
32. Tanaka N, Fujii M, Imoto H, Uchiyama J, Nakano K, Nomura S, Fujisawa H, Kunitsugu I, Saito T, Suzuki M,. (2008) Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip. J Neurosurg 108: 791-797. (Pubitemid 351498976)
33. Traynelis SF, Dingledine R,. (1988) Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J Neurophysiol 59: 259-276. (Pubitemid 18038311)
34. Vastola EF, Homan R, Rosen A,. (1969) Inhibition of focal seizures by moderate hypothermia. A clinical and experimental study. Arch Neurol 20: 430-439.
35. Volgushev M, Vidyasagar TR, Chistiakova M, Eysel UT,. (2000) Synaptic transmission in the neocortex during reversible cooling. Neuroscience 98: 9-22. (Pubitemid 30349139)
36. Yang X-F, Rothman SM,. (2001) Focal cooling rapidly terminates experimental neocortical seizures. Ann Neurol 49: 721-726. (Pubitemid 32530238)
37. Yang X-F, Kennedy BR, Lomber SG, Schmidt RE, Rothman SM,. (2006) Cooling produces minimal neuropathology in neocortex and hippocampus. Neurobiol Dis 23: 637-643. (Pubitemid 44234100)