The isotridecanyl side chain of plusbacin-A3 is essential for the transglycosylase inhibition of peptidoglycan biosynthesis

Biochemistry

Volumn 52, Issue 11, 2013, Pages 1973-1979

  Kim, Sung Joon ^a   Singh, Manmilan ^b   Wohlrab, Aaron ^c   Yu, Tsyr Yan ^b   Patti, Gary J ^b   O'Connor, Robert D ^b   Vannieuwenhze, Michael ^c   Schaefer, Jacob ^b  

^a BAYLOR UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTI-MICROBIAL ACTIVITY; GRAM-POSITIVE PATHOGENS; MEMBRANE BILAYERS; MEMBRANE DISRUPTION; ROTATIONAL ECHO DOUBLE RESONANCE; STAPHYLOCOCCUS AUREUS; TRANSGLYCOSYLATION;

AMINO ACIDS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CELLS;

CYTOLOGY;

ALANINE; GLYCINE; GLYCOSYLTRANSFERASE; LYSINE; NUCLEOTIDE; PEPTIDE; PEPTIDOGLYCAN; PLUSBACIN A3; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERIAL STRAIN; ELECTRON NUCLEAR DOUBLE RESONANCE; ENZYME INHIBITION; GLYCOSYLATION; LIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS AGALACTIAE;

ANTI-INFECTIVE AGENTS; BACTERIA; BACTERIAL INFECTIONS; DEPSIPEPTIDES; ENZYME INHIBITORS; HUMANS; PEPTIDOGLYCAN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 84875457296     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4000222     Document Type: Article

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