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Volumn 36, Issue 4, 2013, Pages 935-942

Fibroblast growth factor 21 levels in young healthy females display day and night variations and are increased in response to short-term energy deprivation through a leptin-independent pathway

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FIBROBLAST GROWTH FACTOR 21; LEPTIN; METRELEPTIN;

EID: 84875435352     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-0497     Document Type: Article
Times cited : (17)

References (39)
  • 1
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 2000;1492:203-206
    • (2000) Biochim Biophys Acta , vol.1492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 3
    • 0034649608 scopus 로고    scopus 로고
    • Attenuation of FGF signalling in mouse beta-cells leads to diabetes
    • Hart AW, BaezaN, Apelqvist A, Edlund H. Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Nature 2000; 408:864-868
    • (2000) Nature , vol.408 , pp. 864-868
    • Hart, A.W.1    Baezan Apelqvist, A.2    Edlund, H.3
  • 4
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • Xu J, Lloyd DJ, Hale C, et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009;58:250-259
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3
  • 5
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X, Yeung DC, Karpisek M, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008;57:1246-1253
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3
  • 6
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care 2009;32:1542-1546
    • (2009) Diabetes Care , vol.32 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 7
    • 78049297991 scopus 로고    scopus 로고
    • Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
    • Fisher FM, Chui PC, Antonellis PJ, et al. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 2010; 59:2781-2789
    • (2010) Diabetes , vol.59 , pp. 2781-2789
    • Fisher, F.M.1    Chui, P.C.2    Antonellis, P.J.3
  • 8
    • 84855473367 scopus 로고    scopus 로고
    • High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects
    • Chen C, Cheung BM, Tso AW, et al. High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care 2011;34:2113-2115
    • (2011) Diabetes Care , vol.34 , pp. 2113-2115
    • Chen, C.1    Cheung, B.M.2    Tso, A.W.3
  • 9
    • 48349127924 scopus 로고    scopus 로고
    • The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man
    • Gälman C, Lundåsen T, Kharitonenkov A, et al. The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. Cell Metab 2008;8:169-174
    • (2008) Cell Metab , vol.8 , pp. 169-174
    • Gälman, C.1    Lundåsen, T.2    Kharitonenkov, A.3
  • 10
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • Dushay J, Chui PC, Gopalakrishnan GS, et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 2010;139:456-463
    • (2010) Gastroenterology , vol.139 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3
  • 11
    • 79956113302 scopus 로고    scopus 로고
    • Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans
    • Yu H, Xia F, Lam KS, et al. Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clin Chem 2011; 57:691-700
    • (2011) Clin Chem , vol.57 , pp. 691-700
    • Yu, H.1    Xia, F.2    Lam, K.S.3
  • 12
    • 80052519903 scopus 로고    scopus 로고
    • Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers
    • Andersen B, Beck-Nielsen H, Højlund K. Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers. Clin Endocrinol (Oxf) 2011;75:514-519
    • (2011) Clin Endocrinol (Oxf) , vol.75 , pp. 514-519
    • Andersen, B.1    Beck-Nielsen, H.2    Højlund, K.3
  • 13
    • 69949107891 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man
    • Christodoulides C, Dyson P, Sprecher D, Tsintzas K, Karpe F. Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man. J Clin EndocrinolMetab 2009;94:3594-3601
    • (2009) J Clin EndocrinolMetab , vol.94 , pp. 3594-3601
    • Christodoulides, C.1    Dyson, P.2    Sprecher, D.3    Tsintzas, K.4    Karpe, F.5
  • 14
    • 67650263853 scopus 로고    scopus 로고
    • Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    • Mai K, Andres J, Biedasek K, et al. Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes 2009;58:1532-1538
    • (2009) Diabetes , vol.58 , pp. 1532-1538
    • Mai, K.1    Andres, J.2    Biedasek, K.3
  • 15
    • 21844471790 scopus 로고    scopus 로고
    • Role of leptin in energy-deprivation states: Normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa
    • Chan JL, Mantzoros CS. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet 2005;366:74-85
    • (2005) Lancet , vol.366 , pp. 74-85
    • Chan, J.L.1    Mantzoros, C.S.2
  • 16
    • 0035128497 scopus 로고    scopus 로고
    • Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes
    • Frühbeck G, Gómez-Ambrosi J, Salvador J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J 2001;15: 333-340
    • (2001) FASEB J , vol.15 , pp. 333-340
    • Frühbeck, G.1    Gómez-Ambrosi, J.2    Salvador, J.3
  • 18
    • 51649118899 scopus 로고    scopus 로고
    • Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa
    • Dostálov́a I, Kaválková P, Haluzíková D, et al. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab 2008;93:3627-3632
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3627-3632
    • Dostálová, I.1    Kaválková, P.2    Haluzíková, D.3
  • 19
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-252
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 20
    • 4344690525 scopus 로고    scopus 로고
    • Recombinant human leptin in women with hypothalamic amenorrhea
    • Welt CK, Chan JL, Bullen J, et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004;351:987-997
    • (2004) N Engl J Med , vol.351 , pp. 987-997
    • Welt, C.K.1    Chan, J.L.2    Bullen, J.3
  • 21
    • 0037651108 scopus 로고    scopus 로고
    • The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    • Chan JL, Heist K, DePaoli AM, Veldhuis JD, Mantzoros CS. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 2003; 111:1409-1421
    • (2003) J Clin Invest , vol.111 , pp. 1409-1421
    • Chan, J.L.1    Heist, K.2    Depaoli, A.M.3    Veldhuis, J.D.4    Mantzoros, C.S.5
  • 22
    • 33744812000 scopus 로고    scopus 로고
    • Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans
    • Chan JL, Matarese G, Shetty GK, et al. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc Natl Acad Sci USA 2006;103:8481-8486
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8481-8486
    • Chan, J.L.1    Matarese, G.2    Shetty, G.K.3
  • 23
    • 34347253938 scopus 로고    scopus 로고
    • Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: Variation of concentration-dependent parameters according to assay
    • Chan JL, Wong SL, Orlova C, Raciti P, Mantzoros CS. Pharmacokinetics of recombinant methionyl human leptin after subcutaneous administration: variation of concentration-dependent parameters according to assay. J Clin Endocrinol Metab 2007;92:2307-2311
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2307-2311
    • Chan, J.L.1    Wong, S.L.2    Orlova, C.3    Raciti, P.4    Mantzoros, C.S.5
  • 24
    • 53549113349 scopus 로고    scopus 로고
    • Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: Regulation by gender and adiposity
    • Chan JL, Wong SL, Mantzoros CS. Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity. Clin Pharmacokinet 2008;47:753-764
    • (2008) Clin Pharmacokinet , vol.47 , pp. 753-764
    • Chan, J.L.1    Wong, S.L.2    Mantzoros, C.S.3
  • 25
    • 2942696467 scopus 로고    scopus 로고
    • Leptin hormonal kinetics in the fed state: Effects of adiposity, age, and gender on endogenous leptin production and clearance rates
    • Wong SL, DePaoli AM, Lee JH, Mantzoros CS. Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. J Clin Endocrinol Metab 2004;89:2672-2677
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2672-2677
    • Wong, S.L.1    Depaoli, A.M.2    Lee, J.H.3    Mantzoros, C.S.4
  • 26
    • 0026015905 scopus 로고
    • Approximate entropy as a measure of system complexity
    • Pincus SM. Approximate entropy as a measure of system complexity. Proc Natl Acad Sci USA 1991;88:2297-2301
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2297-2301
    • Pincus, S.M.1
  • 27
    • 80655145213 scopus 로고    scopus 로고
    • Energy deprivation alters in a leptin-and cortisol-independent manner circulating levels of activin A and follistatin but not myostatin in healthy males
    • Vamvini MT, Aronis KN, Chamberland JP, Mantzoros CS. Energy deprivation alters in a leptin-and cortisol-independent manner circulating levels of activin A and follistatin but not myostatin in healthy males. J Clin Endocrinol Metab 2011;96: 3416-3423
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3416-3423
    • Vamvini, M.T.1    Aronis, K.N.2    Chamberland, J.P.3    Mantzoros, C.S.4
  • 28
    • 77952334180 scopus 로고    scopus 로고
    • Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha
    • Wang Y, Solt LA, Burris TP. Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. J Biol Chem 2010;285:15668-15673
    • (2010) J Biol Chem , vol.285 , pp. 15668-15673
    • Wang, Y.1    Solt, L.A.2    Burris, T.P.3
  • 29
    • 76049093949 scopus 로고    scopus 로고
    • PGC-1alpha negatively regulates hepatic FGF21 expression bymodulating theheme/Rev-Erb(alpha) axis
    • Estall JL, Ruas JL, ChoiCS, et al. PGC-1alpha negatively regulates hepatic FGF21 expression bymodulating theheme/Rev-Erb(alpha) axis. Proc Natl Acad Sci USA 2009;106: 22510-22515
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 22510-22515
    • Estall, J.L.1    Ruas, J.L.2    Choi, C.S.3
  • 30
    • 79953847765 scopus 로고    scopus 로고
    • Sex differences in lipid and lipoprotein metabolism: It's not just about sex hormones
    • Wang X, Magkos F, Mittendorfer B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J Clin Endocrinol Metab 2011;96:885-893
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 885-893
    • Wang, X.1    Magkos, F.2    Mittendorfer, B.3
  • 31
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007;5:415-425
    • (2007) Cell Metab , vol.5 , pp. 415-425
    • Inagaki, T.1    Dutchak, P.2    Zhao, G.3
  • 32
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007;5:426-437
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 33
    • 77953388976 scopus 로고    scopus 로고
    • Physiological modulation of circulating FGF21: Relevance of free fatty acids and insulin
    • Mai K, Bobbert T, GrothC, et al. Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin. Am J Physiol Endocrinol Metab 2010;299:E126-E130
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Mai, K.1    Grothc, B.T.2
  • 34
    • 43549110007 scopus 로고    scopus 로고
    • FGF21 attenuates lipolysis in human adipocytes: A possible link to improved insulin sensitivity
    • Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Rydén M. FGF21 attenuates lipolysis in human adipocytes: a possible link to improved insulin sensitivity. FEBS Lett 2008;582: 1725-1730
    • (2008) FEBS Lett , vol.582 , pp. 1725-1730
    • Arner, P.1    Pettersson, A.2    Mitchell, P.J.3    Dunbar, J.D.4    Kharitonenkov, A.5    Rydén, M.6
  • 35
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • Hotta Y, Nakamura H, Konishi M, et al. Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 2009; 150:4625-4633
    • (2009) Endocrinology , vol.150 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3
  • 36
    • 4644257500 scopus 로고    scopus 로고
    • Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers
    • Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS. Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol (Oxf) 2004;61:332-338
    • (2004) Clin Endocrinol (Oxf) , vol.61 , pp. 332-338
    • Wolfe, B.E.1    Jimerson, D.C.2    Orlova, C.3    Mantzoros, C.S.4
  • 37
    • 0030786810 scopus 로고    scopus 로고
    • Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals
    • Meneilly GS, Ryan AS, Veldhuis JD, Elahi D. Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 1997; 82:4088-4093
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4088-4093
    • Meneilly, G.S.1    Ryan, A.S.2    Veldhuis, J.D.3    Elahi, D.4
  • 38
    • 0028826366 scopus 로고
    • Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion inmen as assessed in an ultrasensitive chemiluminescence assay
    • Veldhuis JD, Liem AY, South S, et al. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion inmen as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 1995;80:3209-322
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3209-3222
    • Veldhuis, J.D.1    Liem, A.Y.2    South, S.3
  • 39
    • 0031791252 scopus 로고    scopus 로고
    • Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects
    • Roelfsema F, Pincus SM, Veldhuis JD. Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects. J Clin Endocrinol Metab 1998;83: 688-692
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 688-692
    • Roelfsema, F.1    Pincus, S.M.2    Veldhuis, J.D.3


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