Effects of pretreatment hypothermia during resuscitated porcine hemorrhagic shock

Critical Care Medicine

Volumn 41, Issue 7, 2013, Pages

  Gröger, Michael ^a   Scheuerle, Angelika ^b   Wagner, Florian ^a   Simon, Florian ^a,c   Matallo, José ^a   McCook, Oscar ^a   Seifritz, Andrea ^a   Stahl, Bettina ^a   Wachter, Ulrich ^a   Vogt, Josef A ^a   Asfar, Pierre ^d   Matejovic, Martin ^e   Möller, Peter ^b   Lampl, Lorenz ^f   Bracht, Hendrik ^a   Calzia, Enrico ^a   Georgieff, Michael ^a   Radermacher, Peter ^a   Stahl, Wolfgang ^a  

^a Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung   (Germany)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d ANGERS UNIVERSITY HOSPITAL   (France)

^e CHARLES UNIVERSITY   (Czech Republic)

^f Bundeswehrkrankenhaus Ulm   (Germany)

Author keywords

apoptosis; heart function; heme oxygenase 1; inducible nitric oxide synthase; inflammation; kidney function; liver function; necrosis; nitrotyrosine; nuclear transcription factor kB; oxidative stress

Indexed keywords

CASPASE 3; NITRIC OXIDE; PROTEIN BCL X;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOMESTIC PIG; FEMALE; HEMODYNAMICS; HEMORRHAGIC SHOCK; HEMOSTASIS; HISTOPATHOLOGY; HYPOTHESIS; INDUCED HYPOTHERMIA; LACTIC ACIDOSIS; MALE; METABOLIC ACIDOSIS; NONHUMAN; OXIDATION; OXYGEN TRANSPORT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RESUSCITATION;

ANIMALS; BLOOD CHEMICAL ANALYSIS; FEMALE; GLUCOSE; HEMODYNAMICS; HYPOTHERMIA, INDUCED; MALE; RANDOM ALLOCATION; RESUSCITATION; SHOCK, HEMORRHAGIC; SWINE; TIME FACTORS;

EID: 84875431634     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31827c0b1f     Document Type: Article

References (55)

1. Kheirbek T, Kochanek AR, Alam HB: Hypothermia in bleeding trauma: A friend or a foe? Scand J Trauma Resusc Emerg Med 2009; 17:65
2. Beilman GJ, Blondet JJ, Nelson TR, et al: Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality. Ann Surg 2009; 249:845-850
3. Shafi S, Elliott AC, Gentilello L: Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma 2005; 59:1081-1085
4. Wang HE, Callaway CW, Peitzman AB, et al: Admission hypothermia and outcome after major trauma. Crit Care Med 2005; 33:1296-1301
5. Trentzsch H, Huber-Wagner S, Hildebrand F, et al; TraumaRegistry DGU: Hypothermia for prediction of death in severely injured blunt trauma patients. Shock 2012; 37:131-139
6. Seekamp A, van Griensven M, Hildebrandt F, et al: Adenosinetriphosphate in trauma-related and elective hypothermia. J Trauma 1999; 47:673-683
7. Norio H, Takasu A, Kawakami M, et al: Rapid body cooling by cold fluid infusion prolongs survival time during uncontrolled hemorrhagic shock in pigs. J Trauma 2002; 52:1056-1061
8. Wu X, Kochanek PM, Cochran K, et al: Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J Trauma 2005; 59:291-299
9. Takasu A, Norio H, Gotoh Y, et al: Effect of induced-hypothermia on short-term survival after volume-controlled hemorrhage in pigs. Resuscitation 2003; 56:319-328
10. George ME, Mulier KE, Beilman GJ: Hypothermia is associated with improved outcomes in a porcine model of hemorrhagic shock. J Trauma 2010; 68:662-668
11. Iyegha UP, Greenberg JJ, Mulier KE, et al: Environmental hypothermia in porcine polytrauma and hemorrhagic shock is safe. Shock 2012; 38:387-394
12. Takasu A, Ishihara S, Anada H, et al: Surface cooling, which fails to reduce the core temperature rapidly, hastens death during severe hemorrhagic shock in pigs. J Trauma 2000; 48:942-947
13. Martini WZ, Pusateri AE, Uscilowicz JM, et al: Independent contributions of hypothermia and acidosis to coagulopathy in swine. J Trauma 2005; 58:1002-1009
14. Martini WZ, Cortez DS, Dubick MA, et al: Thromboelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs. J Trauma 2008; 65:535-543
15. Johnston TD, Chen Y, Reed RL II: Functional equivalence of hypothermia to specific clotting factor deficiencies. J Trauma 1994; 37:413-417
16. Valeri CR, MacGregor H, Cassidy G, et al: Effects of temperature on bleeding time and clotting time in normal male and female volunteers. Crit Care Med 1995; 23:698-704
17. Watts DD, Trask A, Soeken K, et al: Hypothermic coagulopathy in trauma: Effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma 1998; 44:846-854
18. Fairchild KD, Singh IS, Patel S, et al: Hypothermia prolongs activation of NF-kappaB and augments generation of inflammatory cytokines. Am J Physiol, Cell Physiol 2004; 287:C422-C431
19. Bracht H, Scheuerle A, Gröger M, et al: Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock. Crit Care Med 2012; 40:2157-2167
20. Schöchl H, Solomon C, Schulz A, et al: Thromboelastometry (TEM) findings in disseminated intravascular coagulation in a pig model of endotoxinemia. Mol Med 2011; 17:266-272
21. Tomori T, Hupalo D, Teranishi K, et al: Evaluation of coagulation stages of hemorrhaged swine: comparison of thromboelastography and rotational elastometry. Blood Coagul Fibrinolysis 2010; 21:20-27
22. Simon F, Scheuerle A, Gröger M, et al: Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. Shock 2011; 35:156-163
23. Matejovic M, Krouzecky A, Radej J, et al: Coagulation and endothelial dysfunction during longterm hyperdynamic porcine bacteremia- effects of selective inducible nitric oxide synthase inhibition. Thromb Haemost 2007; 97:304-309
24. Velik-Salchner C, Schnürer C, Fries D, et al: Normal values for thromboelastography (ROTEM) and selected coagulation parameters in porcine blood. Thromb Res 2006; 117:597-602
25. Mittermayr M, Margreiter J, Velik-Salchner C, et al: Effects of protamine and heparin can be detected and easily differentiated by modified thromboelastography (Rotem): An in vitro study. Br J Anaesth 2005; 95:310-316
26. Polderman KH, Herold I: Therapeutic hypothermia and controlled normothermia in the intensive care unit: Practical considerations, side effects, and cooling methods. Crit Care Med 2009; 37:1101-1120
27. Laffey JG, Engelberts D, Kavanagh BP: Buffering hypercapnic acidosis worsens acute lung injury. Am J Respir Crit Care Med 2000; 161:141-146
28. Kitakaze M, Takashima S, Funaya H, et al: Temporary acidosis during reperfusion limits myocardial infarct size in dogs. Am J Physiol 1997; 272(5 Pt 2):H2071-H2078
29. Abu Romeh S, Tannen RL: Amelioration of hypoxia-induced lactic acidosis by superimposed hypercapnea or hydrochloric acid infusion. Am J Physiol 1986; 250(4 Pt 2):F702-F709
30. Darlington DN, Kheirabadi BS, Delgado AV, et al: Coagulation changes to systemic acidosis and bicarbonate correction in swine. J Trauma 2011; 71:1271-1277
31. Lesperance RN, Lehmann RK, Harold DM, et al: Recombinant factor VIIa is effective at reversing coagulopathy in a lactic acidosis model. J Trauma Acute Care Surg 2012; 72:123-129
32. Sharma HS, Maulik N, Gho BC, et al: Coordinated expression of heme oxygenase-1 and ubiquitin in the porcine heart subjected to ischemia and reperfusion. Mol Cell Biochem 1996; 157:111-116
33. Chen Z, Chen H, Rhee P, et al: Induction of profound hypothermia modulates the immune/inflammatory response in a swine model of lethal hemorrhage. Resuscitation 2005; 66:209-216
34. Alam HB, Rhee P, Honma K, et al: Does the rate of rewarming from profound hypothermic arrest influence the outcome in a swine model of lethal hemorrhage? J Trauma 2006; 60:134-146
35. Hagiwara S, Iwasaka H, Matsumoto S, et al: Changes in cell culture temperature alter release of inflammatory mediators in murine macrophagic RAW264.7 cells. Inflamm Res 2007; 56:297-303
36. Kimura A, Sakurada S, Ohkuni H, et al: Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells. Crit Care Med 2002; 30:1499-1502
37. Fairchild KD, Singh IS, Carter HC, et al: Hypothermia enhances phosphorylation of I{kappa}B kinase and prolongs nuclear localization of NF-{kappa}B in lipopolysaccharide-activated macrophages. Am J Physiol, Cell Physiol 2005; 289:C1114-C1121
38. Yenari MA, Han HS: Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB). Neurochem Int 2006; 49:164-169
39. Han HS, Karabiyikoglu M, Kelly S, et al: Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab 2003; 23:589-598
40. Webster CM, Kelly S, Koike MA, et al: Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia. Neurobiol Dis 2009; 33:301-312
41. Zheng JH, Gao BT, Jiang ZM, et al: Evaluation of early macrophage activation and NF-kappaB activity in pulmonary injury caused by deep hypothermia circulatory arrest: an experimental study. Pediatr Cardiol 2010; 31:215-221
42. Qing M, Nimmesgern A, Heinrich PC, et al: Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway. Crit Care Med 2003; 31:2769-2775
43. Qing M, Wöltje M, Schumacher K, et al: The use of moderate hypothermia during cardiac surgery is associated with repression of tumour necrosis factor-alpha via inhibition of activating protein-1: An experimental study. Crit Care 2006; 10:R57
44. Kuboki S, Okaya T, Schuster R, et al: Hepatocyte NF-kappaB activation is hepatoprotective during ischemia-reperfusion injury and is augmented by ischemic hypothermia. Am J Physiol Gastrointest Liver Physiol 2007; 292:G201-G207
45. Vazquez-Jimenez JF, Qing M, Hermanns B, et al: Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery. J Am Coll Cardiol 2001; 38:1216-1223
46. Qing M, Vazquez-Jimenez JF, Schumacher K, et al: Moderate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72. J Thorac Cardiovasc Surg 2002; 124:724-731
47. Cooper WA, Duarte IG, Thourani VH, et al: Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis. Ann Thorac Surg 2000; 69:696-702; discussion 703
48. Edwards AD, Yue X, Squier MV, et al: Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun 1995; 217:1193-1199
49. Pastuszko P, Pirzadeh A, Reade E, et al: The effect of hypothermia on neuronal viability following cardiopulmonary bypass and circulatory arrest in newborn piglets. Eur J Cardiothorac Surg 2009; 35:577- 81; discussion 581
50. Lee JH, Suh GJ, Kwon WY, et al: Protective effects of therapeutic hypothermia in post-resuscitation myocardium. Resuscitation 2012; 83:633-639
51. Ananiadou OG, Bibou K, Drossos GE, et al: Effect of profound hypothermia during circulatory arrest on neurologic injury and apoptotic repressor protein Bcl-2 expression in an acute porcine model. J Thorac Cardiovasc Surg 2007; 133:919-926
52. Lelli JL Jr, Becks LL, Dabrowska MI, et al: ATP converts necrosis to apoptosis in oxidant-injured endothelial cells. Free Radic Biol Med 1998; 25:694-702
53. Bradbury DA, Simmons TD, Slater KJ, et al: Measurement of the ADP:ATP ratio in human leukaemic cell lines can be used as an indicator of cell viability, necrosis and apoptosis. J Immunol Methods 2000; 240:79-92
54. Paxian M, Bauer I, Rensing H, et al: Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation. FASEB J 2003; 17:993-1002
55. Siller-Matula JM, Plasenzotti R, Spiel A, et al: Interspecies differences in coagulation profile. Thromb Haemost 2008; 100:397-404