Antagonism of P2Y1-induced vasorelaxation by acyl CoA: A critical role for palmitate and 3′-phosphate

British Journal of Pharmacology

Volumn 168, Issue 8, 2013, Pages 1911-1922

  Alefishat, E ^a,b   Alexander, S P H ^a   Ralevic, V ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF JORDAN   (Jordan)

Author keywords

acetyl CoA; CoA; P2Y receptors; palmitoyl CoA; porcine coronary artery; porcine mesenteric artery; rat thoracic aorta; vasorelaxation

Indexed keywords

3' DEPHOSPHO PALMITOYL COENZYME A DERIVATIVE; 3' RIBOSE PHOSPHATE; 4 (2 IODO 6 METHYLAMINO 9H PURIN 9 YL) 2 PHOSPHONOOXYBICYCLO[3.1.0]HEXANE 1 METHANOL; ACETYL COENZYME A DERIVATIVE; ACYL COENZYME A; ADENOSINE DIPHOSPHATE; COENZYME A DERIVATIVE; PALMITIC ACID; PALMITOYL COENZYME A DERIVATIVE; PHOSPHATE; PURINERGIC P2Y1 RECEPTOR; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; ACETYL COENZYME A; CALCIUM; N(6)-METHYL-2'-DEOXYADENOSINE 3',5'-DIPHOSPHATE; PALMITOYL COENZYME A; PURINERGIC P2Y RECEPTOR ANTAGONIST; URIDINE DIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; ISOMETRICS; MALE; MESENTERIC ARTERY; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; THORACIC AORTA; VASODILATATION; ANALOGS AND DERIVATIVES; ANIMAL; CORONARY BLOOD VESSEL; DRUG EFFECTS; HEK293 CELL LINE; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; PIG; WISTAR RAT;

ACETYL COENZYME A; ACYL COENZYME A; ADENOSINE DIPHOSPHATE; ANIMALS; AORTA, THORACIC; CALCIUM; CORONARY VESSELS; HEK293 CELLS; HUMANS; IN VITRO TECHNIQUES; MALE; MESENTERIC ARTERIES; MUSCLE RELAXATION; PALMITOYL COENZYME A; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2Y1; SWINE; URIDINE DIPHOSPHATE;

EID: 84875423932     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12086     Document Type: Article

References (45)

1. Agius L, Wright PD, Alberti KG, (1987). Carnitine acyltransferases and acyl-CoA hydrolases in human and rat liver. Clin Sci (Lond) 73: 3-10.
2. Alefishat E, Alexander SPH, Ralevic V, (2010). Effect of palmitoyl CoA on ADP-evoked vasorelaxations in porcine isolated coronary and mesenteric arteries. Available at: http://www.fasebj.org/cgi/content/meeting
3. Alexander SPH, Mathie A, Peters JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition (2011). Br J Pharmacol 164 (Suppl. 1): S1-S324.
4. 6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells. Mol Pharmacol 74: 777-784.
5. 1 receptors to the control of coronary blood flow. J Appl Physiol 111: 1744-1750.
6. 1 receptor. Mol Pharmacol 50: 1323-1329.
7. Boyer JL, Siddiqi S, Fischer B, Romero-Avila T, Jacobson KA, Harden TK, (1996b). Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5′-monophosphate. Br J Pharmacol 118: 1959-1964.
8. Boylan JG, Hamilton JA, (1992). Interactions of acyl-coenzyme A with phosphatidylcholine bilayers and serum albumin. Biochemistry 31: 557-567.
9. Bultmann R, Tuluc F, Starke K, (1998). On the suitability of adenosine 3′-phosphate 5′-phosphosulphate as a selective P2Y receptor antagonist in intact tissues. Eur J Pharmacol 359: 95-101.
10. Buvinic S, Briones R, Huidobro-Toro JP, (2002). P2Y(1) and P2Y(2) receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed. Br J Pharmacol 136: 847-856.
11. 1 receptor antagonists. FEBS Lett 536: 145-150.
12. Corr L, Burnstock G, (1994). Analysis of P2-purinoceptor subtypes on the smooth muscle and endothelium of rabbit coronary artery. J Cardiovasc Pharmacol 23: 709-715.
13. Dol-Gleizes F, Mares AM, Savi P, Herbert JM, (1999). Relaxant effect of 2-methyl-thio-adenosine diphosphate on rat thoracic aorta: effect of clopidogrel. Eur J Pharmacol 367: 247-253.
14. Eltze M, Ullrich B, (1996). Characterization of vascular P2 purinoceptors in the rat isolated perfused kidney. Eur J Pharmacol 306: 139-152.
15. 1 receptors after repetitive agonist application. Naunyn Schmiedebergs Arch Pharmacol 371: 466-472.
16. Guns PJ, Korda A, Crauwels HM, Van Assche T, Robaye B, Boeynaems JM, et al. (2005). Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta. Br J Pharmacol 146: 288-295.
17. 2-deficient mice. Br J Pharmacol 147: 569-574.
18. Hansmann G, Bultmann R, Tuluc F, Starke K, (1997). Characterization by antagonists of P2-receptors mediating endothelium-dependent relaxation in the rat aorta. Naunyn Schmiedebergs Arch Pharmacol 356: 641-652.
19. 1 receptors mediate endothelial dependent vasodilation to ATP. Mol Pharmacol 72: 1132-1136.
20. Harris RA, Farmer B, Ozawa T, (1972). Inhibition of the mitochondrial adenine nucleotide transport system by oleyl CoA. Arch Biochem Biophys 150: 199-209.
21. 1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther 316: 556-563.
22. Hertz R, Magenheim J, Berman I, Bar-Tana J, (1998). Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha. Nature 392: 512-516.
23. Keef KD, Pasco JS, Eckman DM, (1992). Purinergic relaxation and hyperpolarization in guinea pig and rabbit coronary artery: role of the endothelium. J Pharmacol Exp Ther 260: 592-600.
24. 1 receptor antagonists. J Med Chem 46: 4974-4987.
25. Knudsen J, Neergaard TB, Gaigg B, Jensen MV, Hansen JK, (2000). Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling. J Nutr 130: 294S-298S.
26. Lerner E, Shug AL, Elson C, Shrago E, (1972). Reversible inhibition of adenine nucleotide translocation by long chain fatty acyl coenzyme A esters in liver mitochondria of diabetic and hibernating animals. J Biol Chem 247: 1513-1519.
27. Li QL, Yamamoto N, Inoue A, Morisawa S, (1990). Fatty acyl-CoAs are potent inhibitors of the nuclear thyroid hormone receptor in vitro. J Biochem 107: 699-702.
28. 12 receptors: a new finding that may influence the design of anti-thrombotic agents. Platelets 19: 134-145.
29. Olivecrona GK, Goteberg M, Harnek J, Wang L, Jacobson KA, Erlinge D, (2004). Coronary artery reperfusion: the ADP receptor P2Y(1) mediates early reactive hyperemia in vivo in pigs. Purinergic Signal 1: 59-65.
30. Pelsers MM, Chapelle JP, Knapen M, Vermeer C, Muijtjens AM, Hermens WT, et al. (1999). Influence of age and sex and day-to-day and within-day biological variation on plasma concentrations of fatty acid-binding protein and myoglobin in healthy subjects. Clin Chem 45: 441-443.
31. Powell GL, Tippett PS, Kiorpes TC, McMillinwood J, Coll KE, Schulz H, et al. (1985). Fatty acyl-CoA as an effector molecule in metabolism. Fed Proc 44: 81-84.
32. Ralevic V, Burnstock G, (1998). Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492.
33. Rapedius M, Soom M, Shumilina E, Schulze D, Schönherr R, Kirsch C, et al. (2005). Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels. J Biol Chem 280: 30760-30767.
34. Rayment SJ, Ralevic V, Barrett DA, Cordell R, Alexander SP, (2007). A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release. FASEB J 21: 577-585.
35. Riedel MJ, Light PE, (2005). Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic beta-cell ATP-sensitive K+ channels. Diabetes 54: 2070-2079.
36. Rose'Meyer RB, Hope W, (1990). Evidence that A2 purinoceptors are involved in endothelium-dependent relaxation of the rat thoracic aorta. Br J Pharmacol 100: 576-580.
37. Saetrum Opgaard O, Edvinsson L, (1997). Mechanical properties and effects of sympathetic co-transmitters on human coronary arteries and veins. Basic Res Cardiol 92: 168-180.
38. Sambandam N, Lopaschuk GD, (2003). AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart. Prog Lipid Res 42: 238-256.
39. 1 receptor to phospholipase C. Br J Pharmacol 122: 1021-1024.
40. Schroeder F, Petrescu AD, Huang H, Atshaves BP, McIntosh AL, Martin GG, et al. (2008). Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. Lipids 43: 1-17.
41. Simonsen U, Garcia-Sacristan A, Prieto D, (1997). Involvement of ATP in the non-adrenergic non-cholinergic inhibitory neurotransmission of lamb isolated coronary small arteries. Br J Pharmacol 120: 411-420.
42. Tippett PS, Neet KE, (1982). Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration. J Biol Chem 257: 12839-12845.
43. Van Breda E, Keizer HA, Vork MM, Surtel DA, De Jong YF, Van Der Vusse GJ, et al. (1992). Modulation of fatty-acid-binding protein content of rat heart and skeletal muscle by endurance training and testosterone treatment. Pflugers Arch 421: 274-279.
44. Von Kugelgen I, (2006). Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110: 415-432.
45. Wunderlich MT, Hanhoff T, Goertler M, Spener F, Glatz JF, Wallesch CW, et al. (2005). Release of brain-type and heart-type fatty acid-binding proteins in serum after acute ischaemic stroke. J Neurol 252: 718-724.