Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: A new finding that may influence the design of anti-thrombotic agents

Platelets

Volumn 19, Issue 2, 2008, Pages 134-145

  Manolopoulos, P ^a   Glenn, J R ^a   Fox, S C ^a   May, J A ^a   Dovlatova, N L ^a   Tang, S W ^a   Thomas, N R ^b   Ralevic, V ^b   Heptinstall, S ^a,c  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Acyl coenzyme A; Adenosine diphosphate; ADP antagonists; Coenzyme A; P2Y12 receptors; P2Y1 receptors; Palmitoyl coenzyme A

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ACYL COENZYME A; ADENOSINE DIPHOSPHATE; ANTICOAGULANT AGENT; ARC 69931; CALCIUM; CANGRELOR; PADGEM PROTEIN; PALMITOYL COENZYME A; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DESIGN; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIGHT SCATTERING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE SHAPE; TURBIDIMETRY;

ADENOSINE DIPHOSPHATE; ADENOSINE MONOPHOSPHATE; BLOOD PLATELETS; CALCIUM; CELL ADHESION MOLECULES; CELL SHAPE; COENZYME A; FIBRINOLYTIC AGENTS; HUMANS; MICROFILAMENT PROTEINS; PALMITOYL COENZYME A; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECEPTORS, PURINERGIC P2;

EID: 39749200011     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.1080/09537100701708498     Document Type: Article

References (20)