The Alkaloid Compound Harmane Increases the Lifespan of Caenorhabditis elegans during Bacterial Infection, by Modulating the Nematode's Innate Immune Response

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Jakobsen, Henrik ^a,b   Bojer, Martin S ^a,b   Marinus, Martin G ^c   Xu, Tao ^c   Struve, Carsten ^b   Krogfelt, Karen A ^b   Løbner Olesen, Anders ^d  

^a ROSKILDE UNIVERSITY   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HARMAN; INSULIN LIKE RECEPTOR; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; TETRACYCLINE; TRANSCRIPTION FACTOR DAF 16; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SCREENING; ENTEROCOCCAL INFECTION; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI INFECTION; F35E12 5 GENE; GENE; GENE EXPRESSION REGULATION; GENE INDUCTION; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VIVO STUDY; INNATE IMMUNITY; LIFE EXTENSION; NONHUMAN; PROTEIN LOCALIZATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; SALMONELLA TYPHIMURIUM; SALMONELLOSIS; SHIGA TOXIN PRODUCING ESCHERICHIA COLI; SURVIVAL RATE; UPREGULATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; COLONY COUNT, MICROBIAL; ESCHERICHIA COLI; HARMINE; HOT TEMPERATURE; HUMANS; IMMUNITY, INNATE; INTESTINES; LONGEVITY; MAP KINASE KINASE 4; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS; ESCHERICHIA COLI; NEMATODA;

EID: 84875410165     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060519     Document Type: Article

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