Efficacy of topical antifungals in the treatment of dermatophytosis: A mixed-treatment comparison meta-analysis involving 14 treatments

JAMA Dermatology

Volumn 149, Issue 3, 2013, Pages 341-349

  Rotta, Inajara ^a   Ziegelmann, Patricia K ^c   Otuki, Michel F ^a   Riveros, Bruno S ^a   Bernardo, Noemia L M C ^d   Correr, Cassyano J ^b  

^a Pharmaceutical Sciences Postgraduate Program   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMOROLFINE; ANTIFUNGAL AGENT; BIFONAZOLE; BUTENAFINE; CICLOPIROX; CICLOPIROXOLAMINE; CLOTRIMAZOLE; ECONAZOLE; FENTICONAZOLE; FLUTRIMAZOLE; ISOCONAZOLE; KETOCONAZOLE; MICONAZOLE; NAFTIFINE; OXICONAZOLE; PLACEBO; SERTACONAZOLE; TERBINAFINE; TIOCONAZOLE;

COMPARATIVE EFFECTIVENESS; DERMATOPHYTOSIS; DRUG EFFICACY; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW;

ADMINISTRATION, CUTANEOUS; ANTIFUNGAL AGENTS; BAYES THEOREM; DATA INTERPRETATION, STATISTICAL; DERMATOMYCOSES; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84875400422     PISSN: 21686068     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamadermatol.2013.1721     Document Type: Review

References (82)

1. Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev. 2007;(3):CD001434.
2. Gupta AK, Einarson TR, Summerbell RC, Shear NH. An overview of topical antifungal therapy in dermatomycoses: a North American perspective. Drugs. 1998;55(5):645-674.
3. Severo LC, Londero AT. Micoses. In: Veronesi R, Focaccia R. Tratado de Infectologia. 2nd ed. São Paulo, Brazil: Atheneu; 2002:1035-1077.
4. Garber G. An overview of fungal infections. Drugs. 2001;61(suppl 1):1-12.
5. Drake LA, Dinehart SM, Farmer ER, et al; Guidelines/Outcomes Committee. American Academy of Dermatology. Guidelines of care for superficial mycotic infections of the skin: tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. J Am Acad Dermatol. 1996;34(2, pt 1):282-286.
6. Hainer BL. Dermatophyte infections. Am Fam Physician. 2003;67(1):101-108.
7. Lu G, Ades AE. Combination of direct and indirect evidence in mixed treatment comparisons. Stat Med. 2004;23(20):3105-3124.
8. Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet. 2009;373(9665):746-758.
9. Psaty BM, Lumley T, Furberg CD, et al. Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysis. JAMA. 2003;289(19):2534-2544.
10. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions; Version 5.1.0. Updated March 2011. http://handbook.cochrane.org/. Accessed July 1, 2011.
11. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17(1):1-12.
12. Spiegelhalter DJ, Best NG, Carlin BP, Van der Linde A. Bayesian measures of model complexity and fit. J R Stat Soc Series B Stat Methodol. 2002;64(4):583-616.
13. Dias S, Welton NJ, Caldwell DM, Ades AE. Checking consistency in mixed treatment comparison meta-analysis. Stat Med. 2010;29(7-8):932-944.
14. Aly R, Fisher G, Katz I, et al. Ciclopirox gel in the treatment of patients with interdigital tinea pedis. Int J Dermatol. 2003;42(suppl 1):29-35.
15. Naftifine Gel Study Group. Naftifine gel in the treatment of tinea pedis: two doubleblind, multicenter studies. Cutis. 1991;48(1):85-88.
16. Berman B, Ellis C, Leyden J, et al. Efficacy of a 1-week, twice-daily regimen of terbinafine 1% cream in the treatment of interdigital tinea pedis: results of placebocontrolled, double-blind, multicenter trials. J Am Acad Dermatol. 1992;26(6): 956-960.
17. Bogaert H, Cordero C, Ollague W, Savin RC, Shalita AR, Zaias N. Multicentre doubleblind clinical trials of ciclopirox olamine cream 1% in the treatment of tinea corporis and tinea cruris. J Int Med Res. 1986;14(4):210-216.
18. Budimulja U, Bramono K, Urip KS, et al. Once daily treatment with terbinafine 1% cream (Lamisil) for one week is effective in the treatment of tinea corporis and cruris: a placebo-controlled study. Mycoses. 2001;44(7-8):300-306.
19. Daily AD, Kramer KJ, Rex IH, Thorne EG. Econazole nitrate (Spectazole) cream, 1 percent: a topical agent for the treatment of tinea pedis. Cutis. 1985;35(3): 278-280.
20. Duncan WC. Tinea pedis: treatment with topical miconazole. Cutis. 1975;16(4): 647-649.
21. Ellis CN, Gammon WR, Goldfarb MT, et al. A placebo-controlled evaluation of once-daily versus twice-daily oxiconazole nitrate (1%) cream in the treatment of tinea pedis. Curr Ther Res. 1989;46(2):269-276.
22. Evans EGV, James IGV, Joshipura RC. Two-week treatment of tinea pedis with terbinafine (Lamisil) 1% cream: a placebo controlled study. J Dermatolog Treat. 1991;2(3):95-97.
23. Evans EGV, Shah JM, Joshipura RC. One-week treatment of tinea corporis and tinea cruriswith terbinafine (Lamisil)1%cream: a placebo-controlled study. J Dermatolog Treat. 1992;3(4):181-184.
24. Fredriksson T. Topical treatment of superficial mycoses with clotrimazole. Postgrad Med J. 1974;50(suppl 1):62-64.
25. Fulton JE Jr. Miconazole therapy for endemic fungal disease. Arch Dermatol. 1975;111(5):596-598.
26. Gentles JC, Jones GR, Roberts DT. Efficacy of miconazole in the topical treatment of tinea pedis in sportsmen. Br J Dermatol. 1975;93(1):79-84.
27. Greer DL, Jolly HW Jr. Treatment of tinea cruris with topical terbinafine. J Am Acad Dermatol. 1990;23(4, pt 2):800-804.
28. Greer DL, Weiss J, Rodriguez DA, Hebert AA, Swinehart JM. A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent. J Am Acad Dermatol. 1997;37(2, pt 1):231-235.
29. Gupta AK, Skinner AR, Cooper EA. Evaluation of the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis (dermatophytosis complex) in a randomized, double-blind, placebo-controlled trial. Int J Dermatol. 2005;44 (7):590-593.
30. Hollmen KA, Kinnunen T, Kiistala U, et al. Efficacy and tolerability of terbinafine 1% emulsion gel in patients with tinea pedis. J Eur Acad Dermatol Venereol. 2002;16(1):87-88.
31. James IG, Loria-Kanza Y, Jones TC. Short-duration topical treatment of tinea pedis using terbinafine emulsion gel: results of a dose-ranging clinical trial. J Dermatolog Treat. 2007;18(3):163-168.
32. Kligman AM, Bogaert H, Cordero C. Evaluation of ciclopirox olamine cream for the treatment of tinea pedis: multicenter, double-blind comparative studies. Clin Ther. 1985;7(4):409-417.
33. Korting HC, Tietz HJ, Bräutigam M, Mayser P, Rapatz G, Paul C; LAS-INT-06 Study Group. One week terbinafine 1% cream (Lamisil) once daily is effective in the treatment of interdigital tinea pedis: a vehicle controlled study. Med Mycol. 2001;39(4):335-340.
34. Kuokkanen K. Topical tioconazole in dermatomycosis. Mykosen. 1982;25(5):274-280.
35. Lebwohl M, Elewski B, Eisen D, Savin RC. Efficacy and safety of terbinafine 1% solution in the treatment of interdigital tinea pedis and tinea corporis or tinea cruris. Cutis. 2001;67(3):261-266.
36. Lesher JL Jr, Babel DE, Stewart DM, et al. Butenafine 1%cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. J Am Acad Dermatol. 1997;36(2, pt 1):S20-S24.
37. Mandy SJ, Garrott TC. Miconazole treatment for severe dermatophytoses. JAMA. 1974;230(1):72-75.
38. Millikan LE. Efficacy and tolerability of topical terbinafine in the treatment of tinea cruris. J Am Acad Dermatol. 1990;23(4, pt 2):795-799.
39. Montoya F, Vélez H. Evaluación terapéutica de naftifine en pacientes con dermatofitosis y pitiriasis versicolor. Acta Med Colomb. 1985;10(2):79-94.
40. Ortiz LGP. Topical miconazole nitrate therapy in tinea pedis and tinea versicolor. Clin Ther. 1978;1(6):444-450.
41. Ortonne JP, Korting HC, Viguié-Vallanet C, Larnier C, Savaluny E. Efficacy and safety of a new single-dose terbinafine 1%formulation in patients with tinea pedis (athlete's foot): a randomized, double-blind, placebo-controlled study. J Eur Acad Dermatol Venereol. 2006;20(10):1307-1313.
42. Reyes BA, Beutner KR, Cullen SI, Rosen T, Shupack JL, Weinstein MB. Butenafine, a fungicidal benzylamine derivative, used once daily for the treatment of interdigital tinea pedis. Int J Dermatol. 1998;37(6):450-453.
43. Savin RC. Treatment of chronic tinea pedis (athlete's foot type) with topical terbinafine. J Am Acad Dermatol. 1990;23(4, pt 2):786-789.
44. Savin R, De Villez RL, Elewski B, et al. One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, doubleblind trial. J Am Acad Dermatol. 1997;36(2, pt 1):S15-S19.
45. Savin R, Jorizzo J. The safety and efficacy of sertaconazole nitrate cream 2% for tinea pedis. Cutis. 2006;78(4):268-274.
46. Smith EB, Graham JL, Ulrich JA. Topical clotrimazole in tinea pedis. South Med J. 1977;70(1):47-48.
47. Smith EB, Noppakun N, Newton RC. A clinical trial of topical terbinafine (a new allylamine antifungal) in the treatment of tinea pedis. J Am Acad Dermatol. 1990;23(4, pt 2):790-794.
48. Spiekermann PH, Young MD. Clinical evaluation of clotrimazole: a broadspectrum antifungal agent. Arch Dermatol. 1976;112(3):350-352.
49. Susilo R, Korting HC, Strauss UP. Dermatomycoses of the glabrous skin: a doubleblind, randomised, comparative trial of sertaconazole 2% cream once daily versus vehicle. Clin Drug Investig. 2003;23(6):387-394.
50. Syed TA, Hadi SM, Qureshi ZA, Ali SM, Ahmad SA. Butenafine 1% versus terbinafine 1% in cream for the treatment of tinea pedis: a placebo-controlled, doubleblind, comparative study. Clin Drug Investig. 2000;19(6):393-397.
51. Tschen E, Elewski B, Gorsulowsky DC, Pariser DM. Treatment of interdigital tinea pedis with a 4-week once-daily regimen of butenafine hydrochloride 1% cream. J Am Acad Dermatol. 1997;36(2, pt 1):S9-S14.
52. Van Heerden JS, Vismer HF. Tinea corporis/cruris: new treatment options. Dermatology. 1997;194(suppl 1):14-18.
53. Ablon G, Rosen T, Spedale J. Comparative efficacy of naftifine, oxiconazole, and terbinafine in short-term treatment of tinea pedis. Int J Dermatol. 1996;35(8): 591-593.
54. Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J; Catalan Flutrimazole Study Group. Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1%cream: efficacy of flutrimazole 1%dermal cream in dermatomycoses. Dermatology. 1995;190(4):295-300.
55. Arreaza de Arreaza F, Diaz de Torres E, Briceno Maaz T. Double-blind comparison of oxiconazole with miconazole for efficacy and local tolerance in patients with cutaneous mycoses. Med Cutan Ibero Lat Am. 1984;12(1):57-61.
56. Bergstresser PR, Elewski B, Hanifin J, et al. Topical terbinafine and clotrimazole in interdigital tinea pedis: a multicenter comparison of cure and relapse rates with 1-and 4-week treatment regimens. J Am Acad Dermatol. 1993;28(4): 648-651.
57. Binet O, Soto-Melo J, Delgadillo J, Videla S, Izquierdo I, Forn J. Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a randomized, multicentre, double-blind, comparative clinical trial with 1% clotrimazole cream. Flutrimazole Study Group. Mycoses. 1994;37(11-12):455-459.
58. Budimulja U. Terbinafine 1%cream vs. bifonazole 1%cream in the treatment of tinea cruris. Int J Dermatol. 1998;37(11):871-873.
59. Clayton YM, Knight AG. A clinical double-blind trial of topical miconazole and clotrimazole against superficial fungal infections and erythrasma. Clin Exp Dermatol. 1976;1(3):225-232.
60. Clayton YM, Hay RJ, McGibbon DH, Pye RJ. Double blind comparison of the efficacy of tioconazole and miconazole for the treatment of fungal infection of the skin or erythrasma. Clin Exp Dermatol. 1982;7(5):543-549.
61. Estrada R, Chávez G, Bonifaz A, et al. Ciclopiroxolamine 1% cream vs clotrimazole 1% cream in tinea pedis: comparative, double blind, multicentric and randomized study. Dermatol Revista Mexicana. 1998;42(5):195-202.
62. Evans EG, Dodman B, Williamson DM, Brown GJ, Bowen RG. Comparison of terbinafine and clotrimazole in treating tinea pedis. BMJ. 1993;307(6905):645- 647.
63. Fredriksson T. Treatment of dermatomycosis with topical miconazole (Daktar). Opusc Med. 1977;21(3):80-81.
64. Fredriksson T. Treatment of dermatomycoses with topical tioconazole and miconazole. Dermatologica. 1983;166(suppl 1):14-19.
65. Ghaninejad H, Gholami K, Hashemi P, et al. Sertaconazole 2%cream vs. miconazole 2% cream for cutaneous mycoses: a double-blind clinical trial. Clin Exp Dermatol. 2009;34(8):e837-e839. doi:10.1111/j.1365-2230.2009.03579.x.
66. Irvine CA, Kenilworth NJ. Naftifine cream 1% versus clotrimazole cream 1% in the treatment of tinea pedis. Naftifine Podiatric Study Group. J Am Podiatr Med Assoc. 1990;80(6):314-318.
67. Korting HC, Klovekorn W, Klovekorn G. Comparative efficacy and tolerability of econazole liposomal gel 1%, branded econazole conventional cream 1% and generic clotrimazole cream 1% in tinea pedis. Clin Drug Investig. 1997;14(4): 286-293.
68. Leenutaphong V, Niumpradit N, Tangwiwat S, Sritaveesuwan R, Muanprasat C. Double-blind study of the efficacy of 1 week topical terbinafine cream compared to 4 weeks miconazole cream in patients with tinea pedis. J Med Assoc Thai. 1999;82(10):1006-1010.
69. Millikan LE, Galen WK, Gewirtzman GB, et al. Naftifine cream 1% versus econazole cream 1% in the treatment of tinea cruris and tinea corporis. J Am Acad Dermatol. 1988;18(1, pt 1):52-56.
70. Pereda J, Noguera X, Boncompte E, Algueró M, Izquierdo I. Efficacy of flutrimazole 1% powder in the treatment of tinea pedis. Mycoses. 2003;46(3-4):126-131.
71. Ramam M, Prasad HR, Manchanda Y, et al. Randomised controlled trial of topical butenafine in tinea cruris and tinea corporis. Indian J Dermatol Venereol Leprol. 2003;69(2):154-158.
72. Sanchez Carazo JL, Fuente C, Oliver V, Umbert P. A comparative study of terbinafine versus bifonazol 1% cream in a daily single dose in tinea pedis. Actas Dermosifiliogr. 1994;85(5):388-394.
73. Schopf R, Hettler O, Bräutigam M, et al. Efficacy and tolerability of terbinafine 1% topical solution used for 1 week compared with 4 weeks clotrimazole 1% topical solution in the treatment of interdigital tinea pedis: a randomized, doubleblind, multi-centre, 8-week clinical trial. Mycoses. 1999;42(5-6):415-420.
74. Singal A, Pandhi D, Agrawal S, Das S. Comparative efficacy of topical 1% buten-afine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, doubleblind trial. J Dermatolog Treat. 2005;16(5-6):331-335.
75. Smith EB, Wiss K, Hanifin JM, et al. Comparison of once and twice-daily naftifine cream regimens with twice-daily clotrimazole in the treatment of tinea pedis. J Am Acad Dermatol. 1990;22(6, pt 1):1116-1117.
76. Suschka S, Fladung B, Merk HF. Clinical comparison of the efficacy and tolerability of once daily Canesten with twice daily Nizoral (clotrimazole 1%cream vs ketoconazole 2% cream) during a 28-day topical treatment of interdigital tinea pedis. Mycoses. 2002;45(3-4):91-96.
77. Wahid Z, Butt J, Nishtar R. Multicentre double-blind study of efficacy and safety of terbinafine 1% cream compared with bifonazole 1% cream in patients with tinea pedis moccasin type. J Dermatolog Treat. 1997;8(4):225-227.
78. del Palacio-Hernanz A, López-Gómez S, Moreno-Palancar P, González-Lastra F. A clinical double-blind trial comparing amorolfine cream 0.5% (RO-14-4767) with bifonazole cream 1% in the treatment of dermatomycoses. Clin Exp Dermatol. 1989;14(2):141-144.
79. Hart R, Bell-Syer SE, Crawford F, Torgerson DJ, Young P, Russell I. Systematic review of topical treatments for fungal infections of the skin and nails of the feet. BMJ. 1999;319(7202):79-82.
80. Rotta I, Sanchez A, Gonçalves PR, Otuki MF, Correr CJ. Efficacy and safety of topical antifungals in the treatment of dermatomycosis: a systematic review. Br J Dermatol. 2012;166(5):927-933.
81. Kyle AA, Dahl MV. Topical therapy for fungal infections. Am J Clin Dermatol. 2004;5(6):443-451.
82. Williams H. Fungal infections of skin and nails of feet: pragmatic clinical trial is now needed. BMJ. 1999;319(7216):1070-1071.