Short-duration topical treatment of tinea pedis using terbinafine emulsion gel: Results of a dose-ranging clinical trial

Journal of Dermatological Treatment

Volumn 18, Issue 3, 2007, Pages 163-168

  James, Ian G ^a   Loria Kanza, Yolanda ^b   Jones, Thomas C ^c  

^a Spring House Surgery   (United Kingdom)

^b NOVARTIS PHARMA K K   (Japan)

^c Clinical Research Consultants   (Switzerland)

Author keywords

Dermatophyte; Emulsion gel; Terbinafine; Tinea pedis

Indexed keywords

PLACEBO; TERBINAFINE;

ADULT; ARTICLE; BURN; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DESQUAMATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRY SKIN; ERYTHEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; OUTPATIENT; PRIORITY JOURNAL; PUSTULE; SKIN IRRITATION; TINEA PEDIS;

ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; ANTIFUNGAL AGENTS; CHILD; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; GELS; GREAT BRITAIN; HUMANS; MALE; NAPHTHALENES; SEVERITY OF ILLNESS INDEX; TINEA PEDIS; TREATMENT OUTCOME;

EID: 34249811512     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.1080/09546630701247971     Document Type: Article

References (14)

1. Brennen B, Leyden JJ. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. J Am Acad Dermatol. 1997;36:S3-S8.
2. Petranyi G, Ryder NS, Stutz A. Allylamine derivatives: A new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science. 1984;224:239-41.
3. Villars V, Jones TC. Clinical efficacy and tolerability of terbinafine (Lamisil) a new topical and systemic fungicidal drug for treatment of dermatomycoses. Clin Exp Dermatol. 1989;14:124-7.
4. Stoughton RB, Sefton J, Zeleznick L. In vitro and in vivo cutaneous penetration and antifungal activity of naftifine. Drugs. 1998;55:645-74.
5. Gupta AJ, Einarson TR, Summerbell RC, Shear NH. An overview of topical antifungal therapy in dermatomycoses. A North American perspective. Dermatology. 1997;194(suppl 1): 19-21.
6. Lee CK, Uchida T, Kitagawa K, Yagi A, Kim NS, Goto S. Effect of hydrophilic and lipophilic vehicles on skin permeation of tegafur, alclofenac and ibuprofen with or without permeation enhancers. Biol Pharm Bull. 1993;161:1264-9.
7. Alberti I, Kalia YN, Naik A, Bonny J, Guy RH. Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo. Int J Pharmacol. 2001;219:11-19.
8. Cramer J, Kshatriya B, Snoddy A. Skin pharmacokinetics of terbinafine in healthy subjects following once-daily application of 1% emulsion gel or 1% cream for 1, 5 or 7 days. In, Meeting guide and abstracts of the 2006 Annual Meeting of the American College of Clinical Pharmacy; October 26-29, 2006; St Louis, MO, Abstract 249.
9. Marks R, Dawber RPR. Skin surface biopsies: An improved technique for the examination of the horny layer. Br J Dermatol. 1971;84:117-23.
10. Hill S, Thomas R, Smith SG, Finlay AY. An investigation of the pharmacokinetics of topical terbinafine (Lamisil) 1% cream. Br J Dermatol. 1992;127:396-400.
11. Hay R, Roberts SOB, Mackenzie DWR. Mycology. In: Campion RH, Burton JL, Ebling FJG, editors. Textbook of dermatology. 5th ed. Oxford: Blackwell Science; 1992. p. 1154-6.
12. Hall JC. Dermatologic mycology. In: Sauer's manual of skin disease. Philadelphia, PA: Lippincott Williams & Wilkins; 2000. p. 200-1.
13. Fitzpatrick RE, Newcomer VD. Skin diseases. In: Feigin RD, Cherry JD, editors. Textbook of pediatric infectious diseases. Philadelphia, PA: WB Saunders; 1987. p. 837-8.
14. Bergstresser PR, Elewski B, Hanifin J, Lesher J, Savin R, Shupack J, et al. Topical terbinafine and clotrimazole in interdigital tinea pedis: A multicenter comparison of cure and relapse rates with 1- and 4-week treatment regimens. J Am Acad Dermatol. 1993;28:648-51.