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Volumn 61, Issue 3, 2013, Pages 808-815

Maraviroc reduces cytokine expression and secretion in human adipose cells without altering adipogenic differentiation

Author keywords

Adipocytes; Cytokines; Inflammation; Lipodystrophy; Maraviroc

Indexed keywords

ADIPOCYTOKINE; CYTOKINE; EFAVIRENZ; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MARAVIROC; MESSENGER RNA; MITOCHONDRIAL DNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84875376516     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2012.12.013     Document Type: Article
Times cited : (25)

References (45)
  • 1
    • 0033102304 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1
    • Shafer R.W., Vuitton D.A. Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1. Biomed Pharmacother 1999, 53:73-86.
    • (1999) Biomed Pharmacother , vol.53 , pp. 73-86
    • Shafer, R.W.1    Vuitton, D.A.2
  • 2
    • 0033803407 scopus 로고    scopus 로고
    • Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy
    • Kaplan J.E., Hanson D., Dworkin M.S., Frederick T., Bertolli J., Lindegren M.L., et al. Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis 2000, 30(Suppl 1):5-14.
    • (2000) Clin Infect Dis , vol.30 , Issue.SUPPL 1 , pp. 5-14
    • Kaplan, J.E.1    Hanson, D.2    Dworkin, M.S.3    Frederick, T.4    Bertolli, J.5    Lindegren, M.L.6
  • 3
    • 0033583977 scopus 로고    scopus 로고
    • Diagnosis, prediction, and natural course of HIV-1 protease inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study
    • Carr A., Samaras K., Thorisdottir A., Kaufmann G.R., Chisholm D.J., Cooper D.A. Diagnosis, prediction, and natural course of HIV-1 protease inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study. Lancet 1999, 353:2093-2099.
    • (1999) Lancet , vol.353 , pp. 2093-2099
    • Carr, A.1    Samaras, K.2    Thorisdottir, A.3    Kaufmann, G.R.4    Chisholm, D.J.5    Cooper, D.A.6
  • 5
    • 2342441342 scopus 로고    scopus 로고
    • Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations
    • Gougeon M.L., Pénicaud L., Fromenty B., Leclercq P., Viard J., Capeau J. Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations. Antiviral Ther 2004, 9:161-177.
    • (2004) Antiviral Ther , vol.9 , pp. 161-177
    • Gougeon, M.L.1    Pénicaud, L.2    Fromenty, B.3    Leclercq, P.4    Viard, J.5    Capeau, J.6
  • 7
    • 2442593038 scopus 로고    scopus 로고
    • In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes
    • El Hadri K., Glorian M., Monsempes C., Dieudonné M.N., Pecquery R., Giudicelli Y., et al. In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes. J Biol Chem 2004, 279:15130-15141.
    • (2004) J Biol Chem , vol.279 , pp. 15130-15141
    • El Hadri, K.1    Glorian, M.2    Monsempes, C.3    Dieudonné, M.N.4    Pecquery, R.5    Giudicelli, Y.6
  • 8
    • 11144268546 scopus 로고    scopus 로고
    • Anti-retroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro
    • Lagathu C., Bastard J.P., Auclair M., Maachi M., Kornprobst M., Capeau J., et al. Anti-retroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro. Antiviral Ther 2004, 9:911-920.
    • (2004) Antiviral Ther , vol.9 , pp. 911-920
    • Lagathu, C.1    Bastard, J.P.2    Auclair, M.3    Maachi, M.4    Kornprobst, M.5    Capeau, J.6
  • 9
    • 36448962356 scopus 로고    scopus 로고
    • Lipodystrophy in HIV 1-infected patients: lessons for obesity research
    • Villarroya F., Domingo P., Giralt M. Lipodystrophy in HIV 1-infected patients: lessons for obesity research. Int J Obes (London) 2007, 31:1763-1776.
    • (2007) Int J Obes (London) , vol.31 , pp. 1763-1776
    • Villarroya, F.1    Domingo, P.2    Giralt, M.3
  • 10
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5    Rao, S.6
  • 11
    • 0025012627 scopus 로고
    • Adipogenesis in a murine bone marrow stromal cell line capable of supporting B lineage lymphocyte growth and proliferation: biochemical and molecular characterization
    • Gimble J.M., Dorheim M.A., Cheng A., Medina K., Wang C.S., Jones R., et al. Adipogenesis in a murine bone marrow stromal cell line capable of supporting B lineage lymphocyte growth and proliferation: biochemical and molecular characterization. Eur J Immunol 1990, 20:379-387.
    • (1990) Eur J Immunol , vol.20 , pp. 379-387
    • Gimble, J.M.1    Dorheim, M.A.2    Cheng, A.3    Medina, K.4    Wang, C.S.5    Jones, R.6
  • 12
    • 78649895037 scopus 로고    scopus 로고
    • Contribution of inflammation to fat redistribution and metabolic disturbances in HIV-1 infected patients
    • Stankov M.V., Behrens G.M. Contribution of inflammation to fat redistribution and metabolic disturbances in HIV-1 infected patients. Curr Pharm Des 2010, 16:3361-3371.
    • (2010) Curr Pharm Des , vol.16 , pp. 3361-3371
    • Stankov, M.V.1    Behrens, G.M.2
  • 13
    • 25844450042 scopus 로고    scopus 로고
    • Antiviral activity and safety of 873140, a novel CCR5 antagonist, during short-term monotherapy in HIV-infected adults
    • Lalezari J., Thompson M., Kumar P., Piliero P., Davey R., Patterson K., et al. Antiviral activity and safety of 873140, a novel CCR5 antagonist, during short-term monotherapy in HIV-infected adults. AIDS 2005, 19:1443-1448.
    • (2005) AIDS , vol.19 , pp. 1443-1448
    • Lalezari, J.1    Thompson, M.2    Kumar, P.3    Piliero, P.4    Davey, R.5    Patterson, K.6
  • 14
    • 34250006524 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults
    • Schürmann D., Fätkenheuer G., Reynes J., Michelet C., Raffi F., van Lier J., et al. Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults. AIDS 2007, 21:1293-1299.
    • (2007) AIDS , vol.21 , pp. 1293-1299
    • Schürmann, D.1    Fätkenheuer, G.2    Reynes, J.3    Michelet, C.4    Raffi, F.5    van Lier, J.6
  • 15
    • 0036779192 scopus 로고    scopus 로고
    • Susceptibility of diverse primary HIV isolates with varying co-receptor specificity's to CXCR4 antagonistic compounds
    • Owen S.M., Rudolph D., Schols D., Fujii N., Yamamoto N., Lal R.B. Susceptibility of diverse primary HIV isolates with varying co-receptor specificity's to CXCR4 antagonistic compounds. J Med Virol 2002, 68:147-155.
    • (2002) J Med Virol , vol.68 , pp. 147-155
    • Owen, S.M.1    Rudolph, D.2    Schols, D.3    Fujii, N.4    Yamamoto, N.5    Lal, R.B.6
  • 16
    • 0141703204 scopus 로고    scopus 로고
    • A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
    • Lin P.F., Blair W., Wang T., Spicer T., Guo Q., Zhou N., et al. A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proc Natl Acad Sci USA 2003, 100:11013-11018.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11013-11018
    • Lin, P.F.1    Blair, W.2    Wang, T.3    Spicer, T.4    Guo, Q.5    Zhou, N.6
  • 17
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
    • Dorr P., Westby M., Dobbs S., Griffin P., Irvine B., Macartney M., et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005, 49:4721-4732.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3    Griffin, P.4    Irvine, B.5    Macartney, M.6
  • 18
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
    • Westby M., Smith-Burchnell C., Mori J., Lewis M., Mosley M., Stockdale M., et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J Virol 2007, 81:2359-2371.
    • (2007) J Virol , vol.81 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3    Lewis, M.4    Mosley, M.5    Stockdale, M.6
  • 19
    • 35548963749 scopus 로고    scopus 로고
    • Treatment with CCR5 antagonists: which patient may have a benefit?
    • Mueller M.C., Bogner J.R. Treatment with CCR5 antagonists: which patient may have a benefit?. Eur J Med Res 2007, 12:441-452.
    • (2007) Eur J Med Res , vol.12 , pp. 441-452
    • Mueller, M.C.1    Bogner, J.R.2
  • 20
    • 0036673024 scopus 로고    scopus 로고
    • Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?
    • Hazan U., Romero I.A., Cancello R., Valente S., Perrin V., Mariot V., et al. Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?. FASEB J 2002, 6:1254-1256.
    • (2002) FASEB J , vol.6 , pp. 1254-1256
    • Hazan, U.1    Romero, I.A.2    Cancello, R.3    Valente, S.4    Perrin, V.5    Mariot, V.6
  • 21
    • 79957953991 scopus 로고    scopus 로고
    • Differential effects of efavirenz and lopinavir/ritonavir on human adipocyte differentiation, gene expression and release of adipokines and pro-inflammatory cytokines
    • Gallego-Escuredo J.M., Del Mar Gutierrez M., Diaz-Delfin J., Domingo J.C., Mateo M.G., Domingo P., et al. Differential effects of efavirenz and lopinavir/ritonavir on human adipocyte differentiation, gene expression and release of adipokines and pro-inflammatory cytokines. Curr HIV Res 2010, 8:545-553.
    • (2010) Curr HIV Res , vol.8 , pp. 545-553
    • Gallego-Escuredo, J.M.1    Del Mar Gutierrez, M.2    Diaz-Delfin, J.3    Domingo, J.C.4    Mateo, M.G.5    Domingo, P.6
  • 23
    • 84861145431 scopus 로고    scopus 로고
    • Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines
    • Díaz-Delfín J., Domingo P., Mateo M.G., Gutierrez M del M., Domingo J.C., Giralt M., et al. Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antimicrob Agents Chemother 2012, 56:3369-3375.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3369-3375
    • Díaz-Delfín, J.1    Domingo, P.2    Mateo, M.G.3    Gutierrez, M.D.M.4    Domingo, J.C.5    Giralt, M.6
  • 24
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • Lin Y., Lee H., Berg A.H., Lisanti M.P., Shapiro L., Scherer PE. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem 2000, 275:24255-24263.
    • (2000) J Biol Chem , vol.275 , pp. 24255-24263
    • Lin, Y.1    Lee, H.2    Berg, A.H.3    Lisanti, M.P.4    Shapiro, L.5    Scherer, P.E.6
  • 25
    • 0034987343 scopus 로고    scopus 로고
    • The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance
    • Caron M., Auclair M., Vigouroux C., Glorian M., Forest C., Capeau J. The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance. Diabetes 2001, 50:1378-1388.
    • (2001) Diabetes , vol.50 , pp. 1378-1388
    • Caron, M.1    Auclair, M.2    Vigouroux, C.3    Glorian, M.4    Forest, C.5    Capeau, J.6
  • 26
    • 0034731520 scopus 로고    scopus 로고
    • Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors
    • Dowell P., Flexner C., Kwiterovich P.O., Lane MD. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol Chem 2000, 275:41325-41332.
    • (2000) J Biol Chem , vol.275 , pp. 41325-41332
    • Dowell, P.1    Flexner, C.2    Kwiterovich, P.O.3    Lane, M.D.4
  • 27
    • 84861695648 scopus 로고    scopus 로고
    • HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes
    • Díaz-Delfín J., Domingo P., Wabitsch M., Giralt M., Villarroya F. HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes. Antiviral Ther 2012, 17:529-540.
    • (2012) Antiviral Ther , vol.17 , pp. 529-540
    • Díaz-Delfín, J.1    Domingo, P.2    Wabitsch, M.3    Giralt, M.4    Villarroya, F.5
  • 28
    • 38749103477 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor gamma and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy
    • Shrivastav S., Kino T., Cunningham T., Ichijo T., Schubert U., Heinklein P., et al. Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor gamma and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy. Mol Endocrinol 2008, 22:234-247.
    • (2008) Mol Endocrinol , vol.22 , pp. 234-247
    • Shrivastav, S.1    Kino, T.2    Cunningham, T.3    Ichijo, T.4    Schubert, U.5    Heinklein, P.6
  • 29
    • 35348983385 scopus 로고    scopus 로고
    • Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women
    • Bulló M., Peeraully M.R., Trayhurn P., Folch J., Salas-Salvadó J. Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. Eur J Endocrinol 2007, 157:303-310.
    • (2007) Eur J Endocrinol , vol.157 , pp. 303-310
    • Bulló, M.1    Peeraully, M.R.2    Trayhurn, P.3    Folch, J.4    Salas-Salvadó, J.5
  • 31
    • 78049319407 scopus 로고    scopus 로고
    • Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients
    • Funderburg N., Kalinowska M., Eason J., Goodrich J., Heera J., Mayer H., et al. Effects of maraviroc and efavirenz on markers of immune activation and inflammation and associations with CD4+ cell rises in HIV-infected patients. PLoS One 2010, 5:e13188.
    • (2010) PLoS One , vol.5
    • Funderburg, N.1    Kalinowska, M.2    Eason, J.3    Goodrich, J.4    Heera, J.5    Mayer, H.6
  • 32
    • 80053644416 scopus 로고    scopus 로고
    • In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells
    • Rossi R., Lichtner M., De Rosa A., Sauzullo I., Mengoni F., Massetti A.P., et al. In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells. Clin Exp Immunol 2011, 166:184-190.
    • (2011) Clin Exp Immunol , vol.166 , pp. 184-190
    • Rossi, R.1    Lichtner, M.2    De Rosa, A.3    Sauzullo, I.4    Mengoni, F.5    Massetti, A.P.6
  • 33
    • 77749271329 scopus 로고    scopus 로고
    • Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection
    • Cooper D.A., Heera J., Goodrich J., Tawadrous M., Saag M., Dejesus E., et al. Maraviroc versus efavirenz, both in combination with zidovudine-lamivudine, for the treatment of antiretroviral-naive subjects with CCR5-tropic HIV-1 infection. J Infect Dis 2010, 201:803-813.
    • (2010) J Infect Dis , vol.201 , pp. 803-813
    • Cooper, D.A.1    Heera, J.2    Goodrich, J.3    Tawadrous, M.4    Saag, M.5    Dejesus, E.6
  • 35
    • 34247592922 scopus 로고    scopus 로고
    • The role of adipokines in relation to HIV lipodystrophy
    • Sweeney L.L., Brennan A.M., Mantzoros C.S. The role of adipokines in relation to HIV lipodystrophy. AIDS 2007, 21:895-904.
    • (2007) AIDS , vol.21 , pp. 895-904
    • Sweeney, L.L.1    Brennan, A.M.2    Mantzoros, C.S.3
  • 36
    • 77955055258 scopus 로고    scopus 로고
    • The HIV-1/HAART associated metabolic syndrome - novel adipokines, molecular associations and therapeutic implications
    • Tsiodras S., Perelas A., Wanke C., Mantzoros C.S. The HIV-1/HAART associated metabolic syndrome - novel adipokines, molecular associations and therapeutic implications. J Infect 2010, 61:101-113.
    • (2010) J Infect , vol.61 , pp. 101-113
    • Tsiodras, S.1    Perelas, A.2    Wanke, C.3    Mantzoros, C.S.4
  • 37
    • 17344384196 scopus 로고    scopus 로고
    • Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia
    • Sarraf P., Frederich R.C., Turner E.M., Ma G., Jaskowiak N.T., Rivet D.J., et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 1997, 185:171-175.
    • (1997) J Exp Med , vol.185 , pp. 171-175
    • Sarraf, P.1    Frederich, R.C.2    Turner, E.M.3    Ma, G.4    Jaskowiak, N.T.5    Rivet, D.J.6
  • 38
    • 0034613023 scopus 로고    scopus 로고
    • Elevated serum leptin concentrations induced by experimental acute inflammation
    • Gualillo O., Eiras S., Lago F., Diéguez C., Casanueva F.F. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci 2000, 67:2433-2441.
    • (2000) Life Sci , vol.67 , pp. 2433-2441
    • Gualillo, O.1    Eiras, S.2    Lago, F.3    Diéguez, C.4    Casanueva, F.F.5
  • 41
    • 30744447460 scopus 로고    scopus 로고
    • Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
    • Fätkenheuer G., Pozniak A.L., Johnson M.A., Plettenberg A., Staszewski S., Hoepelman A.I., et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med 2005, 11:1170-1172.
    • (2005) Nat Med , vol.11 , pp. 1170-1172
    • Fätkenheuer, G.1    Pozniak, A.L.2    Johnson, M.A.3    Plettenberg, A.4    Staszewski, S.5    Hoepelman, A.I.6
  • 42
    • 72949113630 scopus 로고    scopus 로고
    • Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients
    • Yilmaz A., Watson V., Else L., Gisslèn M. Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients. AIDS 2009, 23:2537-2540.
    • (2009) AIDS , vol.23 , pp. 2537-2540
    • Yilmaz, A.1    Watson, V.2    Else, L.3    Gisslèn, M.4
  • 44
    • 77955416696 scopus 로고    scopus 로고
    • Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms
    • Melica G., Canestri A., Peytavin G., Lelievre J.D., Bouvier-Alias M., Clavel C., et al. Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms. AIDS 2010, 24:2130-2133.
    • (2010) AIDS , vol.24 , pp. 2130-2133
    • Melica, G.1    Canestri, A.2    Peytavin, G.3    Lelievre, J.D.4    Bouvier-Alias, M.5    Clavel, C.6
  • 45
    • 0037032926 scopus 로고    scopus 로고
    • HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy
    • Dupin N., Buffet M., Marcelin A.G., Lamotte C., Gorin I., Ait-Arkoub Z., et al. HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy. AIDS 2002, 16:2419-2424.
    • (2002) AIDS , vol.16 , pp. 2419-2424
    • Dupin, N.1    Buffet, M.2    Marcelin, A.G.3    Lamotte, C.4    Gorin, I.5    Ait-Arkoub, Z.6


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