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Volumn 216, Issue 3, 2013, Pages 271-279

Exposure assessment of phthalates in French pregnant women: Results of the ELFE pilot study

Author keywords

Biomonitoring; DEHP; Phthalates; Reverse dosimetry; Toxicokinetics

Indexed keywords

PHTHALIC ACID DERIVATIVE;

EID: 84875365792     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2012.12.005     Document Type: Article
Times cited : (68)

References (60)
  • 2
    • 45749129013 scopus 로고    scopus 로고
    • Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples
    • Adibi J.J., Whyatt R.M., Williams P.L., Calafat A.M., et al. Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples. Environ. Health Perspect. 2008, 116:467-473.
    • (2008) Environ. Health Perspect. , vol.116 , pp. 467-473
    • Adibi, J.J.1    Whyatt, R.M.2    Williams, P.L.3    Calafat, A.M.4
  • 3
    • 63649102703 scopus 로고    scopus 로고
    • Maternal urinary metabolites of di-(2-ethylhexyl)phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study
    • Adibi J.J., Hauser R., Williams P.L., Whyatt R.M., Calafat A.M., Nelson H., Herrick R., Swan S.H. Maternal urinary metabolites of di-(2-ethylhexyl)phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study. Am. J. Epidemiol. 2009, 169:1015-1024.
    • (2009) Am. J. Epidemiol. , vol.169 , pp. 1015-1024
    • Adibi, J.J.1    Hauser, R.2    Williams, P.L.3    Whyatt, R.M.4    Calafat, A.M.5    Nelson, H.6    Herrick, R.7    Swan, S.H.8
  • 4
    • 0035196987 scopus 로고    scopus 로고
    • A biomarker approach to measuring human dietary exposure to certain phthalate diesters
    • Anderson W.A.C., Castle L., Scotter M.J., Massey R.C., et al. A biomarker approach to measuring human dietary exposure to certain phthalate diesters. Food Addit. Contam. 2001, 18:1068-1074.
    • (2001) Food Addit. Contam. , vol.18 , pp. 1068-1074
    • Anderson, W.A.C.1    Castle, L.2    Scotter, M.J.3    Massey, R.C.4
  • 6
    • 14744271278 scopus 로고    scopus 로고
    • Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    • Barr D.B., Wilder L.C., Caudill S.P., Gonzalez A.J., Needham L.L., Pirkle J.L. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ. Health Perspect. 2005, 113:192-200.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 192-200
    • Barr, D.B.1    Wilder, L.C.2    Caudill, S.P.3    Gonzalez, A.J.4    Needham, L.L.5    Pirkle, J.L.6
  • 7
    • 77952110779 scopus 로고    scopus 로고
    • A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan
    • Beaudouin R., Micallef S., Brochot C. A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan. Regul. Toxicol. Pharmacol. 2010, 57:103-116.
    • (2010) Regul. Toxicol. Pharmacol. , vol.57 , pp. 103-116
    • Beaudouin, R.1    Micallef, S.2    Brochot, C.3
  • 9
    • 58349092507 scopus 로고    scopus 로고
    • Phthalate exposure among pregnant women in Jerusalem, Israel: results of a pilot study
    • Berman T., Hochner-Celnikier D., Calafat A.M., Needham L.L., et al. Phthalate exposure among pregnant women in Jerusalem, Israel: results of a pilot study. Environ. Int. 2009, 35:353-357.
    • (2009) Environ. Int. , vol.35 , pp. 353-357
    • Berman, T.1    Hochner-Celnikier, D.2    Calafat, A.M.3    Needham, L.L.4
  • 10
    • 0002381794 scopus 로고    scopus 로고
    • MCSim: a simulation program
    • Available from: (software available from: )
    • Bois F.Y., Maszle D. MCSim: a simulation program. J. Stat. Softw. 1997, 2(9). Available from: http://www.stat.ucla.edu/journals/jss/v02/i09 (software available from: www.toxi.ineris.fr).
    • (1997) J. Stat. Softw. , vol.2 , Issue.9
    • Bois, F.Y.1    Maszle, D.2
  • 11
    • 0842285399 scopus 로고    scopus 로고
    • Vinggegaard Steroidogenesis in fetal male rats induced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats
    • Borch J., Ladefoged O., Hass U., Vinggegaard Steroidogenesis in fetal male rats induced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats. Reprod. Toxicol. 2004, 18:53-61.
    • (2004) Reprod. Toxicol. , vol.18 , pp. 53-61
    • Borch, J.1    Ladefoged, O.2    Hass, U.3
  • 12
    • 33645884713 scopus 로고    scopus 로고
    • Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal testis
    • Borch J., Axelstad M., Vinggegaard A.M., Dalgaard M. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal testis. Toxicol. Lett. 2006, 163:183-190.
    • (2006) Toxicol. Lett. , vol.163 , pp. 183-190
    • Borch, J.1    Axelstad, M.2    Vinggegaard, A.M.3    Dalgaard, M.4
  • 14
    • 0039714373 scopus 로고    scopus 로고
    • CSTEE (Scientific Committee on Toxicity, Ecotoxicity and the Environment)
    • CSTEE (Scientific Committee on Toxicity, Ecotoxicity and the Environment) Opinion Expressed at the 6th CSTEE Plenary Meeting 1998.
    • (1998) Opinion Expressed at the 6th CSTEE Plenary Meeting
  • 15
    • 84875366987 scopus 로고    scopus 로고
    • CSTEE (Scientific Committee on Toxicity, Ecotoxicity and the Environment),. Opinion on the results of the Risk Assessment of Bis(2-ethylhexyl)phthalate (DEHP). European Commission.
    • CSTEE (Scientific Committee on Toxicity, Ecotoxicity and the Environment), 2002. Opinion on the results of the Risk Assessment of Bis(2-ethylhexyl)phthalate (DEHP). European Commission.
    • (2002)
  • 16
    • 84875370016 scopus 로고    scopus 로고
    • European Chemicals Bureau, European Chemicals Bureau (ECB), 2004. Risk Assessment Report for Bis(2-ethylhexyl)phthalate (Consolidated Final Report: February ). Doc. No. R042_0402_env_hh_4-6.
    • European Chemicals Bureau, European Chemicals Bureau (ECB), 2004. Risk Assessment Report for Bis(2-ethylhexyl)phthalate (Consolidated Final Report: February 2004). Doc. No. R042_0402_env_hh_4-6.
    • (2004)
  • 17
    • 33749661607 scopus 로고    scopus 로고
    • Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials
    • EFSA (European Food Safety Authority)
    • EFSA (European Food Safety Authority) Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials. EFSA J. 2005, 243:1-20.
    • (2005) EFSA J. , vol.243 , pp. 1-20
  • 18
    • 33749661607 scopus 로고    scopus 로고
    • Di-butylphthalate (DBP) for use in food contact materials
    • EFSA (European Food Safety Authority)
    • EFSA (European Food Safety Authority) Di-butylphthalate (DBP) for use in food contact materials. EFSA J. 2005, 242:1-17.
    • (2005) EFSA J. , vol.242 , pp. 1-17
  • 19
    • 33749661607 scopus 로고    scopus 로고
    • Butylbenzylphthalate (BBP) for use in food contact materials
    • EFSA (European Food Safety Authority)
    • EFSA (European Food Safety Authority) Butylbenzylphthalate (BBP) for use in food contact materials. EFSA J. 2005, 241:1-14.
    • (2005) EFSA J. , vol.241 , pp. 1-14
  • 20
    • 77951696100 scopus 로고    scopus 로고
    • Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ
    • Engel S.M., Miodovnik A., Canfield R.L., Zhu C., et al. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ. Health Perspect. 2010, 118:565-571.
    • (2010) Health Perspect. , vol.118 , pp. 565-571
    • Engel, S.M.1    Miodovnik, A.2    Canfield, R.L.3    Zhu, C.4
  • 21
    • 33645220588 scopus 로고    scopus 로고
    • Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters
    • (discussion 181-185)
    • Foster P.M. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int. J. Androl. 2006, 29:140-147. (discussion 181-185).
    • (2006) Int. J. Androl. , vol.29 , pp. 140-147
    • Foster, P.M.1
  • 22
    • 34848893570 scopus 로고    scopus 로고
    • Intake of phthalates and di(2-ethylhexyl)adipate: results ofthe Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data
    • Fromme H., Gruber L., Schlummer M., Wolz G., et al. Intake of phthalates and di(2-ethylhexyl)adipate: results ofthe Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data. Environ. Int. 2007, 33:1012-1020.
    • (2007) Environ. Int. , vol.33 , pp. 1012-1020
    • Fromme, H.1    Gruber, L.2    Schlummer, M.3    Wolz, G.4
  • 23
    • 37849022338 scopus 로고    scopus 로고
    • Correlation between production amounts of DEHP and daily intake
    • Helm D. Correlation between production amounts of DEHP and daily intake. Sci. Total Environ. 2007, 388:389-391.
    • (2007) Sci. Total Environ. , vol.388 , pp. 389-391
    • Helm, D.1
  • 25
    • 0020967037 scopus 로고
    • Measurement of muscle mass in humans: validity of the 24-h urinary creatinine method
    • Heymsfield S.B., Arteaga C., McManus C., Smith J., Moffitt S. Measurement of muscle mass in humans: validity of the 24-h urinary creatinine method. Am. J. Clin. Nutr. 1983, 37:478-494.
    • (1983) Am. J. Clin. Nutr. , vol.37 , pp. 478-494
    • Heymsfield, S.B.1    Arteaga, C.2    McManus, C.3    Smith, J.4    Moffitt, S.5
  • 26
    • 84875367940 scopus 로고    scopus 로고
    • Not too pretty: phthalates, beauty products and the FDA. Environmental Working Group, Coming Clean, and Health Care Without Harm. Available from:.
    • Houlihan, J., Brody, C., Schwan, B., 2002. Not too pretty: phthalates, beauty products and the FDA. Environmental Working Group, Coming Clean, and Health Care Without Harm. Available from:. http://www.nottoopretty.org/images/.
    • (2002)
    • Houlihan, J.1    Brody, C.2    Schwan, B.3
  • 27
    • 34548743984 scopus 로고    scopus 로고
    • Associations between urinary phthalate monoesters and thyroid hormones in pregnant women
    • Huang P.C., Kuo P.L., Guo Y.L., Liao P.C., Lee C.C. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum. Reprod. 2007, 22:2715-2722.
    • (2007) Hum. Reprod. , vol.22 , pp. 2715-2722
    • Huang, P.C.1    Kuo, P.L.2    Guo, Y.L.3    Liao, P.C.4    Lee, C.C.5
  • 30
    • 0037345870 scopus 로고    scopus 로고
    • An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population
    • Koch H.M., Drexler H., Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int. J. Hyg. Environ. Health 2003, 206:77-83.
    • (2003) Int. J. Hyg. Environ. Health , vol.206 , pp. 77-83
    • Koch, H.M.1    Drexler, H.2    Angerer, J.3
  • 31
    • 2442661389 scopus 로고    scopus 로고
    • Di(2-ethylhexyl)- phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP
    • Koch H.M., Bolt H.M., Angerer J. Di(2-ethylhexyl)- phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP. Arch. Toxicol. 2004, 78:123-130.
    • (2004) Arch. Toxicol. , vol.78 , pp. 123-130
    • Koch, H.M.1    Bolt, H.M.2    Angerer, J.3
  • 32
    • 22844433529 scopus 로고    scopus 로고
    • New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuteriumlabelled DEHP
    • Koch H.M., Bolt H.M., Preuss R., Angerer J. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuteriumlabelled DEHP. Arch. Toxicol. 2005, 79:367-376.
    • (2005) Arch. Toxicol. , vol.79 , pp. 367-376
    • Koch, H.M.1    Bolt, H.M.2    Preuss, R.3    Angerer, J.4
  • 33
    • 33847399071 scopus 로고    scopus 로고
    • Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers
    • Koch H.M., Muller J., Angerer J. Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers. J. Chromatogr. B 2007, 847:114-125.
    • (2007) J. Chromatogr. B , vol.847 , pp. 114-125
    • Koch, H.M.1    Muller, J.2    Angerer, J.3
  • 34
    • 33846258744 scopus 로고    scopus 로고
    • Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP
    • Koch H.M., Angerer J. Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. Int. J. Hyg. Environ. Health 2007, 210:9-19.
    • (2007) Int. J. Hyg. Environ. Health , vol.210 , pp. 9-19
    • Koch, H.M.1    Angerer, J.2
  • 36
    • 4444227801 scopus 로고    scopus 로고
    • Diverse developmental toxicity of di-n-butylphthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation
    • Lee K.Y., Shibutani M., Takagi H., Kato N., Takigami S., Uneyama C., Hirose M. Diverse developmental toxicity of di-n-butylphthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation. Toxicology 2004, 203:221-238.
    • (2004) Toxicology , vol.203 , pp. 221-238
    • Lee, K.Y.1    Shibutani, M.2    Takagi, H.3    Kato, N.4    Takigami, S.5    Uneyama, C.6    Hirose, M.7
  • 37
    • 73649145527 scopus 로고    scopus 로고
    • A simple pharmacokinetic model to characterize exposure of Americans to di-2-ethylhexyl phthalate
    • Lorber M., Angerer J., Koch H.M. A simple pharmacokinetic model to characterize exposure of Americans to di-2-ethylhexyl phthalate. J. Expo. Sci. Environ. Epidemiol. 2010, 20:38-53.
    • (2010) J. Expo. Sci. Environ. Epidemiol. , vol.20 , pp. 38-53
    • Lorber, M.1    Angerer, J.2    Koch, H.M.3
  • 38
    • 80054827544 scopus 로고    scopus 로고
    • A critical evaluation of the creatinine correction approach: can it underestimate intakes of phthalates? A case study with di-2-ethylhexyl phthalate
    • Lorber M., Koch H.M., Angerer J. A critical evaluation of the creatinine correction approach: can it underestimate intakes of phthalates? A case study with di-2-ethylhexyl phthalate. J. Expo. Sci. Environ. Epidemiol. 2011, 21:576-586.
    • (2011) J. Expo. Sci. Environ. Epidemiol. , vol.21 , pp. 576-586
    • Lorber, M.1    Koch, H.M.2    Angerer, J.3
  • 39
    • 33845869799 scopus 로고    scopus 로고
    • Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood
    • Mose T., Mortensen G.K., Hedegaard M., et al. Phthalate monoesters in perfusate from a dual placenta perfusion system, the placenta tissue and umbilical cord blood. Reprod. Toxicol. 2007, 23:83-91.
    • (2007) Reprod. Toxicol. , vol.23 , pp. 83-91
    • Mose, T.1    Mortensen, G.K.2    Hedegaard, M.3
  • 40
    • 85011385846 scopus 로고    scopus 로고
    • NRC (National Research Council) National Academies Press, Washington, DC
    • NRC (National Research Council) Human Biomonitoring for Environmental Chemicals 2006, National Academies Press, Washington, DC.
    • (2006) Human Biomonitoring for Environmental Chemicals
  • 42
    • 0026442320 scopus 로고
    • Serum creatinine as an index of renal function: new insights into old concepts
    • Perrone R.D., Madias N.E., Levey A.S. Serum creatinine as an index of renal function: new insights into old concepts. Clin. Chem. 1992, 38:1933-1953.
    • (1992) Clin. Chem. , vol.38 , pp. 1933-1953
    • Perrone, R.D.1    Madias, N.E.2    Levey, A.S.3
  • 44
    • 84875369960 scopus 로고    scopus 로고
    • R Development Core Team,. R: A Language and Environment for Statistical Computing. Vienna, Austria.
    • R Development Core Team, 2006. R: A Language and Environment for Statistical Computing. Vienna, Austria.
    • (2006)
  • 45
    • 77249101347 scopus 로고    scopus 로고
    • Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis
    • Suzuki Y., Niwa M., Yoshinaga J., Watanabe C., et al. Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis. Environ. Health Prev. Med. 2009, 14:180-187.
    • (2009) Environ. Health Prev. Med. , vol.14 , pp. 180-187
    • Suzuki, Y.1    Niwa, M.2    Yoshinaga, J.3    Watanabe, C.4
  • 46
    • 23744469802 scopus 로고    scopus 로고
    • Study for Future Families Research Team. Decrease in anogenital distance among male infants with prenatal phthalate exposure
    • Swan S.H., Main K.M., Liu F., Stewart S.L., Kruse R.L., Calafat A.M., et al. Study for Future Families Research Team. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ. Health Perspect. 2005, 113:1056-1061.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 1056-1061
    • Swan, S.H.1    Main, K.M.2    Liu, F.3    Stewart, S.L.4    Kruse, R.L.5    Calafat, A.M.6
  • 47
    • 38549160115 scopus 로고    scopus 로고
    • Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    • Teitelbaum S.L., Britton J.A., Calafat A.M., Ye X., Silva M.J., Reidy J.A., et al. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ. Res. 2008, 106:257-269.
    • (2008) Environ. Res. , vol.106 , pp. 257-269
    • Teitelbaum, S.L.1    Britton, J.A.2    Calafat, A.M.3    Ye, X.4    Silva, M.J.5    Reidy, J.A.6
  • 49
    • 0004104069 scopus 로고    scopus 로고
    • US EPA US Environmental Protection Agency, Washington, DC, Available from:
    • US EPA Integrated Risk Information System: Di(2-ethylhexyl)phthalate 2007, US Environmental Protection Agency, Washington, DC, Available from:. http://www.epa.gov/iris/subst/0014.htm.
    • (2007) Integrated Risk Information System: Di(2-ethylhexyl)phthalate
  • 50
    • 0004104069 scopus 로고    scopus 로고
    • US EPA US Environmental Protection Agency, Washington, DC, Available from:
    • US EPA Integrated Risk Information System: Dibutyl Phthalate 2007, US Environmental Protection Agency, Washington, DC, Available from:. http://www.epa.gov/iris/subst/0038.htm.
    • (2007) Integrated Risk Information System: Dibutyl Phthalate
  • 51
    • 0004104069 scopus 로고    scopus 로고
    • US EPA US Environmental Protection Agency, Washington, DC, Available from:
    • US EPA Integrated Risk Information System: Diethyl Phthalate 2007, US Environmental Protection Agency, Washington, DC, Available from:. http://www.epa.gov/iris/subst/0226.htm.
    • (2007) Integrated Risk Information System: Diethyl Phthalate
  • 52
    • 0004104069 scopus 로고    scopus 로고
    • US EPA US Environmental Protection Agency, Washington, DC, Available from:
    • US EPA Integrated Risk Information System: Butyl Benzyl Phthalate 2007, US Environmental Protection Agency, Washington, DC, Available from:. http://www.epa.gov/iris/subst/0293.htm.
    • (2007) Integrated Risk Information System: Butyl Benzyl Phthalate
  • 54
    • 79960653102 scopus 로고    scopus 로고
    • Bisphenol-A and phthalates contamination of urine samples by catheters in the Elfe pilot study: implications for large-scale biomonitoring studies
    • Vandentorren S., Zeman F., Morin L., Sarter H., Bidondo M.-L., Oleko A., Leridon H. Bisphenol-A and phthalates contamination of urine samples by catheters in the Elfe pilot study: implications for large-scale biomonitoring studies. Environ. Res. 2011, 111:761-764.
    • (2011) Environ. Res. , vol.111 , pp. 761-764
    • Vandentorren, S.1    Zeman, F.2    Morin, L.3    Sarter, H.4    Bidondo, M.-L.5    Oleko, A.6    Leridon, H.7
  • 56
    • 78650877458 scopus 로고    scopus 로고
    • Assessing exposure to phthalates - the human biomonitoring approach
    • Wittassek M., Koch H.M., Angerer J., Bruning T. Assessing exposure to phthalates - the human biomonitoring approach. Mol. Nutr. Food Res. 2010, 55:7-31.
    • (2010) Mol. Nutr. Food Res. , vol.55 , pp. 7-31
    • Wittassek, M.1    Koch, H.M.2    Angerer, J.3    Bruning, T.4
  • 57
    • 33745453647 scopus 로고    scopus 로고
    • What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
    • Wormuth M., Scheringer M., Vollenweider M., Hungerbuhler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26:803-824.
    • (2006) Risk Anal. , vol.26 , pp. 803-824
    • Wormuth, M.1    Scheringer, M.2    Vollenweider, M.3    Hungerbuhler, K.4
  • 59
    • 68849107003 scopus 로고    scopus 로고
    • Phthalates biomarker identification and exposure estimates in a population of pregnant women
    • Yan X., Calafat A., Lashley S., Smulian J., Ananth C., Barr D., et al. Phthalates biomarker identification and exposure estimates in a population of pregnant women. Hum. Ecol. Risk Assess. 2009, 15:565-578.
    • (2009) Hum. Ecol. Risk Assess. , vol.15 , pp. 565-578
    • Yan, X.1    Calafat, A.2    Lashley, S.3    Smulian, J.4    Ananth, C.5    Barr, D.6


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