Na+/H+ exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2+ mobilization

Vascular Pharmacology

Volumn 58, Issue 4, 2013, Pages 319-325

  Sasahara, Tomoya ^a   Yayama, Katsutoshi ^a   Matsuzaki, Toshihiro ^b   Tsutsui, Masato ^b   Okamoto, Hiroshi ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Aorta; Intracellular pH; Na+ H+ exchanger inhibitor; Nitric oxide; Relaxation

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; [1,2,4]OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; AMILORIDE; CALCIUM ION; CALMIDAZOLIUM; CARIPORIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIUM DERIVED RELAXING FACTOR; GUANYLATE CYCLASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; THAPSIGARGIN; UNCLASSIFIED DRUG; WORTMANNIN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL PH; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THORACIC AORTA; VASODILATATION;

AMILORIDE; ANIMALS; AORTA, THORACIC; CALCIUM; CALMODULIN; CATTLE; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; GUANIDINES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER; SULFONES; VASODILATION;

EID: 84875365527     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.11.004     Document Type: Article

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