Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Akt pathway in MDA-MB-231 breast cancer cells

Food and Chemical Toxicology

Volumn 56, Issue , 2013, Pages 204-213

  Tang, Linlin ^a   Ma, Xiaowen ^a   Tian, Qi ^a   Cheng, Yanna ^a,b   Yao, Hong ^a   Liu, Zhaopeng ^a,b   Qu, Xianjun ^a,b   Han, Xiuzhen ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Akt; DMBT; MMP 9; Trehalose derivatives; VEGF

Indexed keywords

6,6' BIS(2,3 DIMETHOXYBENZOYL)ALPHA,ALPHA DEXTRO TREHALOSE; ANGIOGENESIS INHIBITOR; ANTIMETASTATIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANTIANGIOGENIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; METASTASIS INHIBITION; MIGRATION INHIBITION; PROTEIN EXPRESSION; WESTERN BLOTTING; ZYMOGRAPHY;

BLOTTING, WESTERN; CELL LINE, TUMOR; DOWN-REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TREHALOSE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84875359127     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.02.032     Document Type: Article

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