α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs

European Journal of Pharmacology

Volumn 705, Issue 1-3, 2013, Pages 1-10

  Kumazaki, Masafumi ^a   Ando, Hitoshi ^a   Kakei, Masafumi ^a   Ushijima, Kentarou ^a   Taniguchi, Yosuke ^b   Yoshida, Masashi ^a   Yamato, Shiho ^a   Washino, Satoshi ^a   Koshimizu, Taka Aki ^a   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

lipoic acid; Arsenic trioxide; hERG; IKr; IKs; QT prolongation

Indexed keywords

ARSENIC TRIOXIDE; DELAYED RECTIFIER POTASSIUM CHANNEL; DIMERCAPROL; POTASSIUM ION; THIOCTIC ACID;

ANESTHESIA INDUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHELATION; COMPLEX FORMATION; CONTINUOUS INFUSION; DRUG BINDING; DRUG DOSE COMPARISON; DRUG STRUCTURE; ELECTROCARDIOGRAPHY; ELECTROSPRAY MASS SPECTROMETRY; GUINEA PIG; HEART MUSCLE CELL; HEART PROTECTION; IN VITRO STUDY; MALE; NONHUMAN; POTASSIUM CURRENT; PR INTERVAL; PRIORITY JOURNAL; QRS COMPLEX; QT PROLONGATION; TIME OF FLIGHT MASS SPECTROMETRY;

ANESTHESIA; ANIMALS; ARSENICALS; CARDIOTONIC AGENTS; DELAYED RECTIFIER POTASSIUM CHANNELS; GUINEA PIGS; LONG QT SYNDROME; MALE; MYOCYTES, CARDIAC; OXIDES; THIOCTIC ACID;

EID: 84875336174     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.02.027     Document Type: Article

References (44)

1. J.T. Barbey, and S. Soignet Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia Ann. Intern. Med. 135 2001 842 843
2. M. Blanusa, V.M. Varnai, M. Piasek, and K. Kostial Chelators as antidotes of metal toxicity: therapeutic and experimental aspects Curr. Med. Chem. 12 2005 2771 2794
3. C.E. Chiang, H.N. Luk, T.M. Wang, and P.Y. Ding Prolongation of cardiac repolarization by arsenic trioxide Blood 100 2002 2249 2252
4. C. Davie, J. Pierre-Valentin, C. Pollard, N. Standen, J. Mitcheson, P. Alexander, and B. Thong Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel J. Cardiovasc. Electrophysiol. 15 2004 1302 1309
5. A. Dennis, L. Wang, X. Wan, and E. Ficker hERG channel trafficking: novel targets in drug-induced long QT syndrome Biochem. Soc. Trans. 35 2007 1060 1063
6. + signaling in beta-cells: implication in the glycemic control in rodents Diabetes 53 2004 3142 3151
7. B. Drolet, C. Simard, and D.M. Roden Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents Circulation 109 2004 26 29
8. E. Ficker, A.T. Dennis, L. Wang, and A.M. Brown Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG Circ. Res. 92 2003 e87 100
9. E. Ficker, Y.A. Kuryshev, A.T. Dennis, C. Obejero-Paz, L. Wang, P. Hawryluk, B.A. Wible, and A.M. Brown Mechanisms of arsenic-induced prolongation of cardiac repolarization Mol. Pharmacol. 66 2004 33 44
10. P. Geelen, B. Drolet, E. Lessard, P. Gilbert, G.E. O'Hara, and J. Turgeon Concomitant block of the rapid (I(Kr)) and slow (I(Ks)) components of the delayed rectifier potassium current is associated with additional drug effects on lengthening of cardiac repolarization J. Cardiovasc. Pharmacol. Ther. 4 1999 143 150
11. J.R. Gurr, D.T. Bau, F. Liu, S. Lynn, and K.Y. Jan Dithiothreitol enhances arsenic trioxide-induced apoptosis in NB4 cells Mol. Pharmacol. 56 1999 102 109
12. E. Hayes, M.K. Pugsley, W.P. Penz, G. Adaikan, and M.J. Walker Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates J. Pharmacol. Toxicol. Methods 32 1994 201 207
13. Y. Hu, L. Su, and E.T. Snow Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes Mutat. Res. 408 1998 203 218
14. M. Huang, Y.T. Wang, and P.C. Ho Quantification of arsenic compounds using derivatization, solvent extraction and liquid chromatography electrospray ionization tandem mass spectrometry J. Pharm. Biomed. Anal. 48 2008 1381 1391
15. K.Y. Jan, T.C. Wang, B. Ramanathan, and J.R. Gurr Dithiol compounds at low concentrations increase arsenite toxicity Toxicol. Sci. 90 2006 432 439
16. M.M. Jones New developments in therapeutic chelating agents as antidotes for metal poisoning Crit. Rev. Toxicol. 21 1991 209 233
17. A.N. Katchman, J. Koerner, T. Tosaka, R.L. Woosley, and S.N. Ebert Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs J. Pharmacol. Exp. Ther. 316 2006 1098 1106
18. 3 poisoning in mice Arch. Toxicol. 64 1990 387 392
19. M. Kumazaki, H. Ando, A. Sasaki, T.A. Koshimizu, K. Ushijima, K. Hosohata, Y. Oshima, and A. Fujimura Protective effect of alpha-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats J. Pharmacol. Sci. 115 2011 244 248
20. J. Kurokawa, L. Chen, and R.S. Kass Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel Proc. Natl. Acad. Sci. USA 100 2003 2122 2127
21. K. Nakajo, M.H. Ulbrich, Y. Kubo, and E.Y. Isacoff Stoichiometry of the KCNQ1-KCNE1 ion channel complex Proc. Natl. Acad. Sci. USA 107 2010 18862 18867
22. M. Nakazaki, M. Kakei, N. Koriyama, and H. Tanaka Involvement of ATP-sensitive K+ channels in free radical-mediated inhibition of insulin secretion in rat pancreatic beta-cells Diabetes 44 1995 878 883
23. C. Niu, H. Yan, T. Yu, H.P. Sun, J.X. Liu, X.S. Li, W. Wu, F.Q. Zhang, Y. Chen, L. Zhou, J.M. Li, X.Y. Zeng, R.R. Yang, M.M. Yuan, M.Y. Ren, F.Y. Gu, Q. Cao, B.W. Gu, X.Y. Su, G.Q. Chen, S.M. Xiong, T.D. Zhang, S. Waxman, Z.Y. Wang, Z. Chen, J. Hu, Z.X. Shen, and S.J. Chen Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients Blood 94 1999 3315 3324
24. K. Ohnishi, H. Yoshida, K. Shigeno, S. Nakamura, S. Fujisawa, K. Naito, K. Shinjo, Y. Fujita, H. Matsui, N. Sahara, A. Takeshita, H. Satoh, H. Terada, and R. Ohno Arsenic trioxide therapy for relapsed or refractory Japanese patients with acute promyelocytic leukemia: need for careful electrocardiogram monitoring Leukemia 16 2002 617 622
25. K. Ohnishi, H. Yoshida, K. Shigeno, S. Nakamura, S. Fujisawa, K. Naito, K. Shinjo, Y. Fujita, H. Matsui, A. Takeshita, S. Sugiyama, H. Satoh, H. Terada, and R. Ohno Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia Ann. Intern. Med. 133 2000 881 885
26. D.M. Roden Clinical practice. Long-QT syndrome N. Engl. J. Med. 358 2008 169 176
27. B. Sakmann, and G. Trube Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart J. Physiol. 347 1984 641 657
28. M.C. Sanguinetti, and N.K. Jurkiewicz Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents J. Gen. Physiol. 96 1990 195 215
29. M.A. Sanz, D. Grimwade, M.S. Tallman, B. Lowenberg, P. Fenaux, E.H. Estey, T. Naoe, E. Lengfelder, T. Buchner, H. Dohner, A.K. Burnett, and F. Lo-Coco Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet Blood 113 2009 1875 1891
30. A. Sasaki, Y. Oshima, and A. Fujimura An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide Exp. Hematol. 35 2007 252 262
31. K.P. Shay, R.F. Moreau, E.J. Smith, A.R. Smith, and T.M. Hagen Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential Biochim. Biophys. Acta 1790 2009 1149 1160
32. Z.X. Shen, G.Q. Chen, J.H. Ni, X.S. Li, S.M. Xiong, Q.Y. Qiu, J. Zhu, W. Tang, G.L. Sun, K.Q. Yang, Y. Chen, L. Zhou, Z.W. Fang, Y.T. Wang, J. Ma, P. Zhang, T.D. Zhang, S.J. Chen, Z. Chen, and Z.Y. Wang Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients Blood 89 1997 3354 3360
33. S. Shibata, Y. Okamoto, S. Endo, and K. Ono Direct effects of esmolol and landiolol on cardiac function, coronary vasoactivity, and ventricular electrophysiology in guinea-pig hearts J. Pharmacol. Sci. 118 2012 255 265
34. C.W. Siu, W.Y. Au, C. Yung, C.R. Kumana, C.P. Lau, Y.L. Kwong, and H.F. Tse Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety Blood 108 2006 103 106
35. A.R. Smith, S.V. Shenvi, M. Widlansky, J.H. Suh, and T.M. Hagen Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress Curr. Med. Chem. 11 2004 1135 1146
36. P.L. Smith, T. Baukrowitz, and G. Yellen The inward rectification mechanism of the HERG cardiac potassium channel Nature 379 1996 833 836
37. S.L. Soignet, S.R. Frankel, D. Douer, M.S. Tallman, H. Kantarjian, E. Calleja, R.M. Stone, M. Kalaycio, D.A. Scheinberg, P. Steinherz, E.L. Sievers, S. Coutre, S. Dahlberg, R. Ellison, and R.P. Warrell Jr. United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia J. Clin. Oncol. 19 2001 3852 3860
38. S.L. Soignet, P. Maslak, Z.G. Wang, S. Jhanwar, E. Calleja, L.J. Dardashti, D. Corso, A. DeBlasio, J. Gabrilove, D.A. Scheinberg, P.P. Pandolfi, and R.P. Warrell Jr. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide N. Engl. J. Med. 339 1998 1341 1348
39. R. Towart, J.T. Linders, A.N. Hermans, J. Rohrbacher, H.J. van der Linde, M. Ercken, M. Cik, P. Roevens, A. Teisman, and D.J. Gallacher Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening? J. Pharmacol. Toxicol. Methods 60 2009 1 10
40. D. Unnikrishnan, J.P. Dutcher, N. Varshneya, R. Lucariello, M. Api, S. Garl, P.H. Wiernik, and S. Chiaramida Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide Blood 97 2001 1514 1516
41. M.A. van der Heyden, M.E. Smits, and M.A. Vos Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon? Br. J. Pharmacol. 153 2008 406 409
42. P. Westervelt, R.A. Brown, D.R. Adkins, H. Khoury, P. Curtin, D. Hurd, S.M. Luger, M.K. Ma, T.J. Ley, and J.F. DiPersio Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide Blood 98 2001 266 271
43. M. Yoshida, M. Nakata, S. Yamato, K. Dezaki, H. Sugawara, S.E. Ishikawa, M. Kawakami, T. Yada, and M. Kakei Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells Biochem. Biophys. Res. Commun. 396 2010 304 309
44. D. Ziegler, M. Hanefeld, K.J. Ruhnau, H. Hasche, M. Lobisch, K. Schutte, G. Kerum, and R. Malessa Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-lipoic acid in diabetic neuropathy Diabetes Care 22 1999 1296 1301