Identifying health effects of exposure to trichloroacetamide using transcriptomics and metabonomics in mice (Mus musculus)

Environmental Science and Technology

Volumn 47, Issue 6, 2013, Pages 2918-2924

  Zhang, Yan ^a   Zhang, Zongyao ^a   Zhao, Yanping ^a   Cheng, Shupei ^a   Ren, Hongqiang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIALLY EXPRESSED GENE; ENERGY METABOLISM; HEPATOTOXICITY; NITROGENOUS DISINFECTION BY-PRODUCTS; PATHWAY ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSCRIPTOMES; TRANSCRIPTOMICS;

AMINO ACIDS; BIOCHEMISTRY; BODY FLUIDS; BYPRODUCTS;

MAMMALS;

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ACETONE; ALANINE; ARGININE; CHOLINE; CITRIC ACID; CREATINE; FORMIC ACID; GLUTAMINE; GLYCEROL; LACTIC ACID; LEUCINE; LIPID; LYSINE; METHIONINE; PHENYLALANINE; PYRUVIC ACID; TAURINE; TRICHLOROACETIMIDIC ACID; TYROSINE; XENOBIOTIC AGENT;

CONCENTRATION (COMPOSITION); GENE; HEALTH CARE; HEALTH RISK; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PARAMETERIZATION; RODENT; SERUM;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMICS; CONTROLLED STUDY; CYTOTOXICITY; ENERGY METABOLISM; GENE EXPRESSION; HEALTH HAZARD; HEPATITIS; HISTOPATHOLOGY; LIPID METABOLISM; LIVER TOXICITY; MALE; METABOLITE; METABONOMICS; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; TRANSCRIPTOMICS; WEIGHT REDUCTION;

ACETAMIDES; ANIMALS; CHLOROACETATES; DISINFECTANTS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; METABOLOMICS; MICE; SERUM; TRANSCRIPTOME; WEIGHT LOSS;

EID: 84875316080     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es3048976     Document Type: Article

References (46)

1. Waller, K.; Swan, S. H.; DeLorenze, G.; Hopkins, B. Trihalomethanes in drinking water and spontaneous abortion Epidemiology 1998, 9 (2) 134-140
2. Liang, L.; Singer, P. C. Factors influencing the formation and relative distribution of haloacetic acids and trihalomethanes in drinking water Environ. Sci. Technol. 2003, 37 (13) 2920-2928
3. Zhang, X.; Echigo, S.; Minear, R. A.; Plewa, M. J., Characterization and comparison of disinfection by-products of four major disinfectants. In Natural Organic Matter and Disinfection by-Products: Characterization and Control in Drinking Water; Barrett, S. E.; Krasner, S. W.; Amy, G. L., Eds.; American Chemical Society: Washington, DC, 2000; pp 299-314.
4. Hua, G. H.; Reckhow, D. A. Comparison of disinfection byproduct formation from chlorine and alternative disinfectants Water Res. 2007, 41 (8) 1667-1678
5. Bond, T.; Huang, J.; Templeton, M. R.; Graham, N. Occurrence and control of nitrogenous disinfection by-products in drinking water-A review Water Res. 2011, 45 (15) 4341-4354
6. Muellner, M. G.; Wagner, E. D.; McCalla, K.; Richardson, S. D.; Woo, Y. T.; Plewa, M. J. Haloacetonitriles vs. regulated haloacetic acids: Are nitrogen-containing DBPs more toxic? Environ. Sci. Technol. 2007, 41 (2) 645-651
7. Plewa, M. J.; Wagner, E. D.; Jazwierska, P.; Richardson, S. D.; Chen, P. H.; McKague, A. B. Halonitromethane drinking water disinfection byproducts: Chemical characterization and mammalian cell cytotoxicity and genotoxicity Environ. Sci. Technol. 2004, 38 (1) 62-68
8. Kundu, B.; Richardson, S. D.; Swartz, P. D.; Matthews, P. P.; Richard, A. M.; DeMarini, D. M. Mutagenicity in Salmonella of halonitromethanes: A recently recognized class of disinfection by-products in drinking water Mutat. Res., Genet. Toxicol. Environ. Mutagen. 2004, 562 (1-2) 39-65
9. Wagner, E. D.; Hsu, K. M.; Lagunas, A.; Mitch, W. A.; Plewa, M. J. Comparative genotoxicity of nitrosamine drinking water disinfection byproducts in Salmonella and mammalian cells Mutat. Res., Genet. Toxicol. Environ. Mutagen. 2012, 741 (1-2) 109-115
10. Krasner, S. W.; Weinberg, H. S.; Richardson, S. D.; Pastor, S. J.; Chinn, R.; Sclimenti, M. J.; Onstad, G. D.; Thruston, A. D. Occurrence of a new generation of disinfection byproducts Environ. Sci. Technol. 2006, 40 (23) 7175-7185
11. Chu, W. H.; Gao, N. Y.; Yin, D. Q.; Krasner, S. W.; Templeton, M. R. Trace determination of 13 haloacetamides in drinking water using liquid chromatography triple quadrupole mass spectrometry with atmospheric pressure chemical ionization J. Chromatogr. A 2012, 1235, 178-181
12. Plewa, M. J.; Muellner, M. G.; Richardson, S. D.; Fasanot, F.; Buettner, K. M.; Woo, Y. T.; McKague, A. B.; Wagner, E. D. Occurrence, synthesis, and mammalian cell cytotoxicity and genotoxicity of haloacetamides: An emerging class of nitrogenous drinking water disinfection byproducts Environ. Sci. Technol. 2008, 42 (3) 955-961
13. Pressman, J. G.; Richardson, S. D.; Speth, T. F.; Miltner, R. J.; Narotsky, M. G.; Hunter, E. S.; Rice, G. E.; Teuschler, L. K.; McDonald, A.; Parvez, S.; Krasner, S. W.; Weinberg, H. S.; McKague, A. B.; Parrett, C. J.; Bodin, N.; Chinn, R.; Lee, C. F. T.; Simmons, J. E. Concentration, chlorination, and chemical analysis of drinking water for disinfection byproduct mixtures health effects research: U.S. EPA's four lab study Environ. Sci. Technol. 2010, 44 (19) 7184-7192
14. Richardson, S. D.; DeMarini, D. M.; Kogevinas, M.; Fernandez, P.; Marco, E.; Lourencetti, C.; Balleste, C.; Heederik, D.; Meliefste, K.; McKague, A. B.; Marcos, R.; Font-Ribera, L.; Grimalt, J. O.; Villanueva, C. M. What's in the pool? A comprehensive identification of disinfection by-products and assessment of mutagenicity of chlorinated and brominated swimming pool water Environ. Health Perspect. 2010, 118 (11) 1523-1530
15. Chu, W. H.; Gao, N. Y.; Krasner, S. W.; Templeton, M. R.; Yin, D. Q. Formation of halogenated C-, N-DBPs from chlor(am)ination and UV irradiation of tyrosine in drinking water Environ. Pollut. 2012, 161, 8-14
16. Chu, W. H.; Gao, N. Y.; Deng, Y. Formation of haloacetamides during chlorination of dissolved organic nitrogen aspartic acid J. Hazardous Mater. 2010, 173 (1-3) 82-86
17. Plewa, M. J.; Wagner, E. D. Mammalian Cell Cytotoxicity and Genotoxicity of Disinfection By-Products; Water Research Foundation: Denver, CO, 2009; p 134.
18. Santos, E. M.; Ball, J. S.; Williams, T. D.; Wu, H. F.; Ortega, F.; Van Aerle, R.; Katsiadaki, I.; Falciani, F.; Viant, M. R.; Chipman, J. K.; Tyler, C. R. Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model Environ. Sci. Technol. 2010, 44 (2) 820-826
19. Meyer, U. A.; Zanger, U. M.; Schwab, M. Omics and drug response Annual Review of Pharmacology and Toxicology 2013, 53, 475-502
20. Zhang, Y.; Zhang, X. X.; Wu, B.; Cheng, S. P. Evaluating the transcriptomic and metabolic profile of mice exposed to source drinking water Environ. Sci. Technol. 2012, 46 (1) 78-83
21. Zhang, Y.; Li, W. X.; Zhang, R.; Sun, J.; Wu, B.; Zhang, X. X.; Cheng, S. P. Preliminary evaluation of gene expression profiles in liver of mice exposed to Taihu Lake drinking water for 90 days Ecotoxicology 2011, 20 (5) 1071-1077
22. Lindon, J. C.; Nicholson, J. K.; Everett, J. R. NMR spectroscopy of biofluids Ann. Rep. NMR Spectrosc. 1999, 38, 1-88
23. Tusher, V. G.; Tibshirani, R.; Chu, G. Significance analysis of microarrays applied to the ionizing radiation response Proc. Natl. Acad. Sci. U.S.A. 2001, 98 (9) 5116-5121
24. Jordan, J.; Zare, A.; Jackson, L. J.; Habibi, H. R.; Weljie, A. M. Environmental contaminant mixtures at ambient concentrations invoke a metabolic stress response in goldfish not predicted from exposure to individual compounds alone J. Proteome Res. 2012, 11 (2) 1133-1143
25. Xia, J. G.; Wishart, D. S. MSEA: A web-based tool to identify biologically meaningful patterns in quantitative metabolomic data Nucleic Acids Res. 2010, 38, W71-W77
26. Yamamoto, A.; Akanuma, S. I.; Tachikawa, M.; Hosoya, K. I. Involvement of LAT1 and LAT2 in the high- and low-affinity transport of l -leucine in human retinal pigment epithelial cells (ARPE-19 Cells) J. Pharm. Sci. 2010, 99 (5) 2475-2482
27. Delorenz., Rj; Ruddle, F. H. Glutamate oxalate transaminase (GOT) genetics in Mus musculus -linkage, polymorphism, and phenotypes of GOT-2 and GOT-1 loci Biochem. Genet. 1970, 4 (2) 259-&
28. Scholl-Burgi, S.; Haberlandt, E.; Heinz-Erian, P.; Deisenhammer, F.; Albrecht, U.; Sigl, S. B.; Rauchenzauner, M.; Ulmer, H.; Karall, D. Amino acid cerebrospinal fluid/plasma ratios in children: Influence of age, gender, and antiepileptic medication Pediatrics 2008, 121 (4) E920-E926
29. Lee, W.; Westerhoff, P.; Croue, J. P. Dissolved organic nitrogen as a precursor for chloroform, dichloroacetonitrile, N-Nitrosodimethylamine, and trichloronitromethane Environ. Sci. Technol. 2007, 41 (15) 5485-5490
30. Sugiyama, K.; Akai, H.; Muramatsu, K. Effects of methionine and related compounds on plasma cholesterol level in rats fed a high cholesterol diet J. Nutr. Sci. Vitaminol. 1986, 32 (5) 537-549
31. Salek, R. M.; Maguire, M. L.; Bentley, E.; Rubtsov, D. V.; Hough, T.; Cheeseman, M.; Nunez, D.; Sweatman, B. C.; Haselden, J. N.; Cox, R. D.; Connor, S. C.; Griffin, J. L. A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human Physiol. Genomics 2007, 29 (2) 99-108
32. Martin, F. P. J.; Dumas, M. E.; Wang, Y. L.; Legido-Quigley, C.; Yap, I. K. S.; Tang, H. R.; Zirah, S.; Murphy, G. M.; Cloarec, O.; Lindon, J. C.; Sprenger, N.; Fay, L. B.; Kochhar, S.; van Bladeren, P.; Holmes, E.; Nicholson, J. K. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Mol. Syst.s Biol. 2007, 3.
33. Ahlborn, G. J.; Nelson, G. M.; Ward, W. O.; Knapp, G.; Allen, J. W.; Ouyang, M.; Roop, B. C.; Chen, Y.; O'Brien, T.; Kitchin, K. T.; Delker, D. A. Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite Toxicol. Appl. Pharmacol. 2008, 227 (3) 400-416
34. Waxman, D. J. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR Arch. Biochem. Biophys. 1999, 369 (1) 11-23
35. Banni, M.; Jebali, J.; Guerbej, H.; Dondero, F.; Boussetta, H.; Viarengo, A. Mixture toxicity assessment of nickel and chlorpyrifos in the sea bass Dicentrarchus labrax Arch. Environ. Contam. Toxicol. 2011, 60 (1) 124-131
36. Xie, Y. X.; Liu, J.; Benbrahim-Tallaa, L.; Ward, J. M.; Logsdon, D.; Diwan, B. A.; Waalkes, M. P. Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic Toxicology 2007, 236 (1-2) 7-15
37. Li, X. C.; Schuler, M. A.; Berenbaum, M. R. Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics Ann. Rev. Entomol. 2007, 52, 231-253
38. Mallei, A.; Giambelli, R.; Gass, P.; Racagni, G.; Mathe, A. A.; Vollmayr, B.; Popoli, M. Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response Neuropharmacology 2011, 60 (7-8) 1243-1253
39. Oexle, H.; Gnaiger, E.; Weiss, G. Iron-dependent changes in cellular energy metabolism: influence on citric acid cycle and oxidative phosphorylation Biochim. Biophys. Acta, Bioenerg. 1999, 1413 (3) 99-107
40. Selak, M. A.; Armour, S. M.; MacKenzie, E. D.; Boulahbel, H.; Watson, D. G.; Mansfield, K. D.; Pan, Y.; Simon, M. C.; Thompson, C. B.; Gottlieb, E. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase Cancer Cell 2005, 7 (1) 77-85
41. Wyss, M.; Smeitink, J.; Wevers, R. A.; Wallimann, T. Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism Biochim. Biophys. Acta 1992, 1102 (2) 119-166
42. Jobgen, W. S.; Fried, S. K.; Fu, W. J.; Meininger, C. J.; Wu, G. Y. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates J. Nutr. Biochem. 2006, 17 (9) 571-588
43. Patel, A. B.; de Graaf, R. A.; Mason, G. F.; Rothman, D. L.; Shulman, R. G.; Behar, K. L. The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo Proc. Natl. Acad. Sci. U.S.A. 2005, 102 (15) 5588-5593
44. Li, P.; Yin, Y. L.; Li, D.; Kim, S. W.; Wu, G. Y. Amino acids and immune function Br. J. Nutr. 2007, 98 (2) 237-252
45. Zhou, C.; Tabb, M. M.; Nelson, E. L.; Grun, F.; Verma, S.; Sadatrafiei, A.; Lin, M.; Mallick, S.; Forman, B. M.; Thummel, K. E.; Blumberg, B. Mutual repression between steroid and xenobiotic receptor and NF-kappa B signaling pathways links xenobiotic metabolism and inflammation J. Clin. Invest. 2006, 116 (8) 2280-2289
46. Havel, P. J. Update on adipocyte hormones-Regulation of energy balance and carbohydrate/lipid metabolism Diabetes 2004, 53, S143-S151