Amino acid cerebrospinal fluid/plasma ratios in children: influence of age, gender, and antiepileptic medication

Pediatrics

Volumn 121, Issue 4, 2008, Pages

  Scholl Bürgi, Sabine ^a,b   Haberlandt, Edda ^a   Heinz Erian, Peter ^b   Deisenhammer, Florian ^c   Albrecht, Ursula ^a   Sigl, Sara Baumgartner ^a   Rauchenzauner, Markus ^a   Ulmer, Hanno ^d   Karall, Daniela ^a  

^a Neuropediatrics and Metabolic Diseases   (Austria)

^b Department of Pediatrics ^*  (Austria)

^c Clinic of Neurology   (Austria)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Amino acids; Blood brain barrier; Child; CSF plasma ratios

Indexed keywords

ALANINE; AMINO ACID; ANTICONVULSIVE AGENT; ARGININE; ASPARAGINE; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; NINHYDRIN; ORNITHINE; PHENOBARBITAL; PHENYLALANINE; PROLINE; SERINE; THREONINE; TYROSINE; VALINE; VALPROIC ACID; BIOLOGICAL MARKER;

ADOLESCENT; AGE DISTRIBUTION; AMINO ACID BLOOD LEVEL; AMINO ACID CEREBROSPINAL FLUID LEVEL; ARTICLE; CEREBROSPINAL FLUID LEVEL; CHILD; CONTROLLED STUDY; EPILEPSY; FEMALE; GROUPS BY AGE; HUMAN; INFANT; ION EXCHANGE CHROMATOGRAPHY; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; MALE; MENTAL DEFICIENCY; NEWBORN; PREDICTOR VARIABLE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEIZURE; SEX DIFFERENCE; VEIN PUNCTURE; AGE; BLOOD; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG EFFECT; HOSPITALIZATION; METABOLISM; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

ADOLESCENT; AGE FACTORS; AMINO ACIDS; ANTICONVULSANTS; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EPILEPSY; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LINEAR MODELS; MALE; MENTAL RETARDATION; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; SEIZURES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 42949109280     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-1631     Document Type: Article

References (23)

1. Begley DJ, Brightman MW. Structural and functional aspects of the blood-brain barrier. Prog Drug Res. 2003;61:41-78
2. Hawkins RA, O'Kane RL, Simpson IA, Vina JR. Structure of the blood-brain barrier and its role in the transport of amino acids. J Nutrition Suppl. 2006;136(1 suppl):218-226
3. De Vivo DC, Trifiletti RR, Jacobson RI, et al. Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N Engl J Med. 1991;325(10):703-709
4. Wang D, Pascual JM, Yang H, et al. Glut-1 deficiency syndrome: clinical, genetic, and therapeutic aspects. Ann Neurol. 2005;57(1):111-118
5. Crawford PM, Lloyd KG, Chadwick DW. CSF gradients for amino acid neurotransmitters. J Neurol Neurosurg Psych. 1988; 51(9):1193-1200
6. European Research Network for Inborn Errors of Metabolism. Available at: www.erndimqa.nl. Accessed February 8, 2008
7. Liappis N, Jäkel A, Bantzer P. Verhalten der freien Aminosäu-ren im Liquor cerebrospinalis von Kindern. Klin Pädiat. 1977; 189(2):155-160
8. Heiblim DI, Evans HE, Glass L, Agbayani MM. Amino acid concentrations in cerebrospinal fluid. Arch Neurol. 1978;35(11):765-768
9. Applegarth DA, Edelsten AD, Wong LTK, Morrison BJ. Observed range of assay values for plasma and cerebrospinal fluid amino acid levels in infants and children aged 3 month to 10 years. Clin Biochem. 1979;12(5):173-178
10. Gerrits GP, Trijbels FJ, Monnens LA, et al. Reference values for amino acids in cerebrospinal fluid of children determined using ion-exchange chromatography with fluorimetric detection. Clin Chim Acta. 1989;182(3):271-280
11. Jones CM, Smith M, Henderson MJ. Reference data for cere- brospinal fluid and the utility of amino acid measurement for diagnosis of inborn errors of metabolism. Ann Clin Biochem. 2006;43(pt 1):63-66
12. Applegarth DA, Toone JR. Nonketotic hyperglycinaemia (glycine encephalopathy): laboratory diagnosis. Mol Genet Metab. 2001;74(1-2):139 -146
13. Gerrits GPJM, Kamphuis S, Monnens LAH, etal. Cerebrospinal fluid levels of amino acids in infants and young children with chronic renal failure. Neuroped. 1998;29(1):35-39
14. Perry TL, Hansen S, Kennedy J. CSF amino acids and plasma- CSF amino acid ratios in adults. J Neurochem. 1975;24(3):587-589
15. Kruse T, Reiber H, Neuhoff V. Amino acid transport across the human blood-CSF barrier. J Neurolog Sci. 1985;70(2):129-138
16. Plum CM. Free amino acid levels in the cerebrospinal fluid of normal humans and their variation in cases of epilepsy and Spielmeyer-Vogt-Batten disease. J Neurochem. 1974;23(3):595-600
17. McGale EHF, Pye IF, Stonier C, Hutchinson EC, Aber GM. Studies of the inter-relationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals. J Neurochem. 1977;29(2):291-297
18. Ko F-J, Chiang C-H, Liu W-J, Chiang W. Alteration of amino acid in plasma and cerebrospinal fluid of children with seizure disorders. Kaohsiung J Med Sci. 1993;9(3):131-142
19. Vossler DG, Wilensky AJ, Cawthon DF, et al. Serum and CSF glutamine levels in valproate-related hyperammonemic en- cephalopathy. Epilepsia. 2002;43(2):154-159
20. Antoshechkin AG, Chentsova TV, Tatur VY, et al. Content of phenylalanine, tyrosine and their metabolites in CSF in phe- nylketonuria. J Inherit Metab Dis. 1991;14(5):749-754
21. Ratzmann GW, Grimm U, Jahrig K, Knapp A. On the brain barrier system function and changes of cerebrospinal fluid concentrations of phenylalanine and tyrosine in human phe- nylketonuria. Biomed Biochim Acta. 1984;43(2):197-204
22. de Koning TJ, Klomp LWJ. Serine deficiency syndromes. Curr Opin Neurol. 2004;17(2):197-204
23. de Koning TJ, Duran M, Van Maldergren L, et al. Congenital microcephaly and seizures due to 3-phosphoglycerate dehy- drogenase deficiency: outcome of treatment with amino acids. J Inherit Metab Dis. 2002;25(2):119-125