In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs

European Journal of Pharmaceutical Sciences

Volumn 49, Issue 2, 2013, Pages 117-124

  Holm, René ^a,b   Meng Lund, Emil ^b   Andersen, Morten B ^a,b   Jespersen, Mads L ^a,b   Karlsson, Jens Jacob ^a   Garmer, Mats ^a   Jørgensen, Erling B ^a   Jacobsen, Jette ^b  

^a H LUNDBECK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Buccal absorption; IVIVC; Metoprolol; Mini pigs; pH; TR146 cell culture

Indexed keywords

METOPROLOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CHEEK MUCOSA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; EX VIVO STUDY; IN VITRO STUDY; IN VIVO STUDY; MINIPIG; NONHUMAN; PH; PRIORITY JOURNAL; SWINE;

ABSORPTION; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; GELS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; METOPROLOL; MOUTH MUCOSA; SWINE;

EID: 84875304967     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.02.024     Document Type: Article

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