Radiation Therapy in the Management of Breast Cancer

Surgical Clinics of North America

Volumn 93, Issue 2, 2013, Pages 455-471

  Jonathan Yang, T ^a   Ho, Alice Y ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Breast cancer; Breast conserving therapy; Ductal carcinoma in situ; Postmastectomy irradiation; Radiation therapy

Indexed keywords

CYCLOPHOSPHAMIDE; FLUOROURACIL; METHOTREXATE; PLACEBO; TAMOXIFEN;

BODY POSITION; BRACHYTHERAPY; BRACHYTHERAPY IMPLANT; BREAST CANCER; BREAST TUMOR; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; COLLAGEN DISEASE; EARLY CANCER; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FIBROSIS; FOLLOW UP; HUMAN; INTRADUCTAL CARCINOMA; INTRAOPERATIVE RADIOTHERAPY; LYMPH NODE DISSECTION; MASTECTOMY; META ANALYSIS (TOPIC); OVERALL SURVIVAL; PARTIAL MASTECTOMY; PHASE 3 CLINICAL TRIAL (TOPIC); PREGNANCY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOTHERAPY EQUIPMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RHEUMATOID ARTHRITIS; SCLERODERMA; SYSTEMIC LUPUS ERYTHEMATOSUS; WIDE EXCISION;

BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; DOSE FRACTIONATION; FEMALE; HUMANS; MASTECTOMY, SEGMENTAL; NEOPLASM STAGING; PATIENT SELECTION; PRONE POSITION; RADIOTHERAPY, ADJUVANT; TREATMENT OUTCOME;

EID: 84875298859     PISSN: 00396109     EISSN: 15583171     Source Type: Journal    
DOI: 10.1016/j.suc.2013.01.002     Document Type: Review

References (64)

1. Clarke M., Collins R., Darby S., et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005, 366:2087-2106.
2. Fisher B., Dignam J., Wolmark N., et al. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. J Clin Oncol 1998, 16:441-452.
3. Wapnir I.L., Dignam J.J., Fisher B., et al. Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS. J Natl Cancer Inst 2011, 103:478-488.
4. Bijker N., Meijnen P., Peterse J.L., et al. Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853-a study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group. J Clin Oncol 2006, 24:3381-3387.
5. Holmberg L., Garmo H., Granstrand B., et al. Absolute risk reductions for local recurrence after postoperative radiotherapy after sector resection for ductal carcinoma in situ of the breast. J Clin Oncol 2008, 26:1247-1252.
6. Cuzick J., Sestak I., Pinder S.E., et al. Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. Lancet Oncol 2011, 12:21-29.
7. Correa C., McGale P., Taylor C., et al. Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr 2010, 2010:162-177.
8. Wong J.S., Kaelin C.M., Troyan S.L., et al. Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol 2006, 24:1031-1036.
9. Hughes L.L., Wang M., Page D.L., et al. Local excision alone without irradiation for ductal carcinoma in situ of the breast: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009, 27:5319-5324.
10. Arriagada R., Le M.G., Rochard F., et al. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol 1996, 14:1558-1564.
11. Blichert-Toft M., Rose C., Andersen J.A., et al. Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst Monogr 1992, (11):19-25.
12. Blichert-Toft M., Nielsen M., During M., et al. Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol. Acta Oncol 2008, 47:672-681.
13. Fisher B., Anderson S., Bryant J., et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002, 347:1233-1241.
14. Poggi M.M., Danforth D.N., Sciuto L.C., et al. Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial. Cancer 2003, 98:697-702.
15. van Dongen J.A., Voogd A.C., Fentiman I.S., et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000, 92:1143-1150.
16. Veronesi U., Cascinelli N., Mariani L., et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002, 347:1227-1232.
17. Clark R.M., Whelan T., Levine M., et al. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst 1996, 88:1659-1664.
18. Fisher B., Bryant J., Dignam J.J., et al. Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol 2002, 20:4141-4149.
19. Liljegren G., Holmberg L., Adami H.O., et al. Sector resection with or without postoperative radiotherapy for stage I breast cancer: five-year results of a randomized trial. Uppsala-Orebro Breast Cancer Study Group. J Natl Cancer Inst 1994, 86:717-722.
20. Liljegren G., Holmberg L., Bergh J., et al. 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol 1999, 17:2326-2333.
21. Darby S., McGale P., Correa C., et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 2011, 378:1707-1716.
22. Radiation Therapy Oncology Group (RTOG) 1014 Protocol. A phase II study of repeat breast preserving surgery and 3D-conformal partial breast rirradiation (PBRI) for local recurrence of breast carcinoma. 2010. Available at:. http://www.rtog.org/ClinicalTrials/ProtocolTable/StudyDetails.aspx%3Fstudy=1014.
23. Morris M.M., Powell S.N. Irradiation in the setting of collagen vascular disease: acute and late complications. J Clin Oncol 1997, 15:2728-2735.
24. Chen A.M., Obedian E., Haffty B.G. Breast-conserving therapy in the setting of collagen vascular disease. Cancer J 2001, 7:480-491.
25. Bartelink H., Horiot J.C., Poortmans P., et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001, 345:1378-1387.
26. Bartelink H., Horiot J.C., Poortmans P.M., et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol 2007, 25:3259-3265.
27. Hughes K.S., Schnaper L.A., Berry D., et al. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med 2004, 351:971-977.
28. Hughes K.S., Schnaper L.A., Cirrincione C., et al. Lumpectomy plus tamoxifen with or without irradiation in women age 70 or older with early breast cancer. J Clin Oncol 2010, 28:15s. [abstract 507].
29. Fyles A.W., McCready D.R., Manchul L.A., et al. Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med 2004, 351:963-970.
30. Fletcher G.H. Hypofractionation: lessons from complications. Radiother Oncol 1991, 20:10-15.
31. Bentzen S.M., Agrawal R.K., Aird E.G., et al. The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol 2008, 9:331-341.
32. Whelan T.J., Pignol J.P., Levine M.N., et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med 2010, 362:513-520.
33. Bentzen S.M., Agrawal R.K., Aird E.G., et al. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet 2008, 371:1098-1107.
34. Smith B.D., Bentzen S.M., Correa C.R., et al. Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys 2011, 81:59-68.
35. Alonso-Basanta M., Ko J., Babcock M., et al. Coverage of axillary lymph nodes in supine vs. prone breast radiotherapy. Int J Radiat Oncol Biol Phys 2009, 73:745-751.
36. Kirby A.M., Evans P.M., Donovan E.M., et al. Prone versus supine positioning for whole and partial-breast radiotherapy: a comparison of non-target tissue dosimetry. Radiother Oncol 2010, 96:178-184.
37. Stegman L.D., Beal K.P., Hunt M.A., et al. Long-term clinical outcomes of whole-breast irradiation delivered in the prone position. Int J Radiat Oncol Biol Phys 2007, 68:73-81.
38. Veronesi U., Marubini E., Mariani L., et al. Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol 2001, 12:997-1003.
39. Fisher B., Jeong J.H., Anderson S., et al. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med 2002, 347:567-575.
40. Holland R., Veling S.H., Mravunac M., et al. Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer 1985, 56:979-990.
41. European Institute of Oncology Intraoperative Radiotherapy with Electrons (EIO) Trial 2000. Available at:. http://www.ieo.it/Italiano/Pages/Default.aspx.
42. NSABP B-39/RTOG 0413 phase III randomized study of adjuvant whole-breast versus partial-breast irradiation in women with ductal carcinoma in situ or stage I or II breast cancer. 2005. Available at:. http://www.cancer.gov/clinicaltrials/search/view%3Fcdrid=409590%26version=HealthProfessional.
43. Ontario Clinical Oncology Group (OCOG) Trial NCT00282035. RAPID: randomized trial of accelerated partial breast irradiation. 2006. Available at:. http://www.clinicaltrials.gov/ct2/show/NCT00282035%3Fterm=NCT00282035%26rank=1.
44. Polgar C., Fodor J., Major T., et al. Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma-5-year results of a randomized trial. Int J Radiat Oncol Biol Phys 2007, 69:694-702.
45. Vaidya J.S., Joseph D.J., Tobias J.S., et al. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 2010, 376:91-102.
46. Medical Research Council- UK IMPORT LOW Trial. 2007. Available at:. http://www.mrc.ac.uk/index.htm.
47. European Brachytherapy Breast Cancer GEC-ESTRO Working Group APBI Trial. 2007. Available at:. http://www.apbi.uni-erlangen.de/.
48. Offersen B.V., Overgaard M., Kroman N., et al. Accelerated partial breast irradiation as part of breast conserving therapy of early breast carcinoma: a systematic review. Radiother Oncol 2009, 90:1-13.
49. Zwicker R.D., Arthur D.W., Kavanagh B.D., et al. Optimization of planar high-dose-rate implants. Int J Radiat Oncol Biol Phys 1999, 44:1171-1177.
50. Vicini F., Beitsch P., Quiet C., et al. Five-year analysis of treatment efficacy and cosmesis by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2011, 79:808-817.
51. Magee B., Swindell R., Harris M., et al. Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial. Radiother Oncol 1996, 39:223-227.
52. Chen P.Y., Wallace M., Mitchell C., et al. Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2010, 76:991-997.
53. Overgaard M., Hansen P.S., Overgaard J., et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 1997, 337:949-955.
54. Overgaard M., Jensen M.B., Overgaard J., et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 1999, 353:1641-1648.
55. Ragaz J., Olivotto I.A., Spinelli J.J., et al. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst 2005, 97:116-126.
56. Nielsen H.M., Overgaard M., Grau C., et al. Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies. J Clin Oncol 2006, 24:2268-2275.
57. Overgaard M., Nielsen H.M., Overgaard J. Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials. Radiother Oncol 2007, 82:247-253.
58. Harris J.R., Halpin-Murphy P., McNeese M., et al. Consensus Statement on postmastectomy radiation therapy. Int J Radiat Oncol Biol Phys 1999, 44:989-990.
59. Recht A., Edge S.B., Solin L.J., et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol 2001, 19:1539-1569.
60. National Comprehensive Cancer Network (NCCN) Guidelines. Available at:. http://www.nccn.org.
61. Recht A., Gray R., Davidson N.E., et al. Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group. J Clin Oncol 1999, 17:1689-1700.
62. Katz A., Buchholz T.A., Thames H., et al. Recursive partitioning analysis of locoregional recurrence patterns following mastectomy: implications for adjuvant irradiation. Int J Radiat Oncol Biol Phys 2001, 50:397-403.
63. Wallgren A., Bonetti M., Gelber R.D., et al. Risk factors for locoregional recurrence among breast cancer patients: results from International Breast Cancer Study Group Trials I through VII. J Clin Oncol 2003, 21:1205-1213.
64. Cheng S.H., Horng C.F., West M., et al. Genomic prediction of locoregional recurrence after mastectomy in breast cancer. J Clin Oncol 2006, 24:4594-4602.