Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: An update

Journal of the National Cancer Institute

Volumn 88, Issue 22, 1996, Pages 1659-1664

  Clark, R M ^a   Whelan, T ^b   Levine, M ^b,c   Roberts, R ^b   Willan, A ^b   McCulloch, P ^c   Lipa, M ^d   Wilkinson, R H ^e   Mahoney, L J ^f  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c JURAVINSKI CANCER CENTRE   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e NORTH YORK GENERAL HOSPITAL   (Canada)

^f ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AXILLARY LYMPH NODE; BREAST CANCER; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; PARTIAL MASTECTOMY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; AXILLA; BREAST NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPH NODE EXCISION; MASTECTOMY, SEGMENTAL; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; RISK; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 0029807835     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/88.22.1659     Document Type: Article

References (13)

1. Clark RM, McCulloch PB, Levine MN, Lipa M, Wilkinson RH. Mahoney LJ, et al. Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer. J Natl Cancer Inst 1992;84:683-9.
2. Fisher B, Bauer M, Margolese R, Poisson R, Pilch Y, Redmond C, et al. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 1985;312:665-73.
3. Sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. Uppsala-Orebro Breast Cancer Study Group [see comment citation in Medline]. J Natl Cancer Inst 1990;82:277-82.
4. Veronesi U, Luini A, Del Vecchio M, Greco M, Galimberti V, Merson M, et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast [see comment citations in Medline]. N Engl J Med 1993;328:1587-91.
5. Fisher B, Anderson S, Redmond CK, Wolmark N, Wickerham DL, Cronin WM. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer [see comment citations in Medline]. N Engl J Med 1995;333:1456-61.
6. Liljegren GG, Holmberg L, Adami HO, Westman G, Graffman S, Bergh J. Sector resection with or without postoperative radiotherapy for stage I breast cancer: five-year results of a randomized trial. Uppsala-Orebro Breast Cancer Study Group [see comment citations in Medline]. J Natl Cancer Inst 1994;86:717-22.
7. Fowble B. Is there a subset of patients with early stage breast cancer for whom irradiation may not be indicated after conservative surgery alone? The Breast J 1995;1:79-90.
8. Gelber RD, Goldhirsch A. Radiotherapy to the conserved breast: is it avoidable if the cancer is small? [editorial] [see comment citations in Medline]. J Natl Cancer Inst 1994;86:652-4.
9. Cuzick J, Stewart H, Rutqvist L, Houghton J, Edwards R, Redmond C, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy [prior annotation incorrect] [see comment citations in Medline]. J Clin Oncol 1994;12:447-53.
10. Rutqvist LE, Johansson H. Mortality by laterality of the primary tumor among 55,000 breast cancer patients from the Swedish Cancer Registry. Br J Cancer 1990;61:866-8.
11. Early Breast Cancer Trialists Collaborative Group. Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials. Early Breast Cancer Trialists Collaborative Group [see comment citations in Medline]. N Engl J Med 1995;333:1444-55.
12. Schnitt SJ, Hayman J, Gelman R, Eberlein TJ, Love SM, Mayzel K, et al. A prospective study of conservative surgery alone in the treatment of selected patients with stage I breast cancer. Cancer 1996;77:1094-100.
13. Nemoto T, Patel JK, Rosner D, Dao TL, Schuh M, Penetrante R. Factors affecting recurrence in lumpectomy without irradiation for breast cancer. Cancer 1991;67:2079-82.