Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes

Gastroenterology

Volumn 144, Issue 5, 2013, Pages

  Budhu, Anuradha ^a   Roessler, Stephanie ^a   Zhao, Xuelian ^a   Yu, Zhipeng ^a   Forgues, Marshonna ^a   Ji, Junfang ^a   Karoly, Edward ^b   Qin, Lun Xiu ^c   Ye, Qing Hai ^c   Jia, Hu Liang ^c   Fan, Jia ^c   Sun, Hui Chuan ^c   Tang, Zhao You ^c   Wang, Xin Wei ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b METABOLON INC   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

Fatty Acid; HpSC HCC; MH HCC; Stem Cell

Indexed keywords

ACYL COENZYME A DESATURASE; ALPHA FETOPROTEIN; LIPID; MESSENGER RNA; PALMITIC ACID; RNA; SMALL INTERFERING RNA; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; CANCER TISSUE; CARCINOGENICITY; CELL CYCLE; CELL INVASION; CELL MIGRATION; COHORT ANALYSIS; COLONY FORMATION; CONTROLLED STUDY; DATA BASE; DISEASE ASSOCIATION; EARLY CANCER; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA ISOLATION; SIGNAL TRANSDUCTION; SURVIVAL TIME; TRANSCRIPTOMICS; TREATMENT OUTCOME; VALIDATION PROCESS;

EID: 84875295407     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.01.054     Document Type: Article

References (41)

1. A. Sreekumar, L.M. Poisson, T.M. Rajendiran Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression Nature 457 2009 910 914
2. U.D. Akavia, O. Litvin, J. Kim An integrated approach to uncover drivers of cancer Cell 143 2010 1005 1017
3. J. Nielsen, S. Oliver The next wave in metabolome analysis Trends Biotechnol 23 2005 544 546
4. M. Heinemann, R. Zenobi Single cell metabolomics Curr Opin Biotechnol 22 2011 26 31
5. A. Budhu, M. Forgues, Q.H. Ye Prediction of venous metastases, recurrence and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment Cancer Cell 10 2006 99 111
6. H.L. Jia, Q.H. Ye, L.X. Qin Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma Clin Cancer Res 13 2007 1133 1139
7. Q.H. Ye, L.X. Qin, M. Forgues Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning Nat Med 9 2003 416 423
8. T. Yamashita, M. Forgues, W. Wang EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma Cancer Res 68 2008 1451 1461
9. J.S. Lee, J. Heo, L. Libbrecht A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells Nat Med 12 2006 410 416
10. Y. Hoshida, A. Villanueva, J.M. Llovet Molecular profiling to predict hepatocellular carcinoma outcome Expert Rev Gastroenterol Hepatol 3 2009 101 103
11. S.S. Thorgeirsson, J.W. Grisham Molecular pathogenesis of human hepatocellular carcinoma Nat Genet 31 2002 339 346
12. D.M. Parkin, F. Bray, J. Ferlay Global cancer statistics, 2002 CA Cancer J Clin 55 2005 74 108
13. T. Reya, S.J. Morrison, M.F. Clarke Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111
14. J. Ji, T. Yamashita, A. Budhu Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells Hepatology 50 2009 472 480
15. T. Yamashita, J. Ji, A. Budhu EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features Gastroenterology 136 2009 1012 1024
16. S. Roessler, H.L. Jia, A. Budhu A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients Cancer Research 70 2010 10202 10212
17. L.M. McShane, D.G. Altman, W. Sauerbrei Reporting recommendations for tumor marker prognostic studies (REMARK) J Natl Cancer Inst 97 2005 1180 1184
18. K.A. Lawton, A. Berger, M. Mitchell Analysis of the adult human plasma metabolome Pharmacogenomics 9 2008 383 397
19. C.D. DeHaven, A.M. Evans, H. Dai Organization of GC/MS and LC/MS metabolomics data into chemical libraries J Cheminform 2 2010 9
20. A.M. Evans, C.D. DeHaven, T. Barrett Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems Anal Chem 81 2009 6656 6667
21. H.J. Welters, E. Diakogiannaki, J.M. Mordue Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic beta-cells exposed to palmitate Apoptosis 11 2006 1231 1238
22. J. Ji, L. Zhao, A. Budhu Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma J Hepatol 52 2010 690 697
23. R. Hill, H. Wu PTEN, stem cells, and cancer stem cells J Biol Chem 284 2009 11755 11759
24. J.M. Ntambi, M. Miyazaki Regulation of stearoyl-CoA desaturases and role in metabolism Prog Lipid Res 43 2004 91 104
25. D. Hanahan, R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
26. E. Kim, N.C. Liu, I.C. Yu Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity Diabetes 60 2011 1493 1503
27. B. Martin-Castillo, A. Vazquez-Martin, C. Oliveras-Ferraros Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena Cell Cycle 9 2010 1057 1064
28. J.K. Yee, C.S. Mao, H.S. Hummel Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells J Lipid Res 49 2008 2124 2134
29. P. Laurent-Puig, P. Legoix, O. Bluteau Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis Gastroenterology 120 2001 1763 1773
30. E. Wurmbach, Y.B. Chen, G. Khitrov Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma Hepatology 45 2007 938 947
31. T. Chen, G. Xie, X. Wang Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma Mol Cell Proteomics 10 2011 M110
32. H. Wu, R. Xue, L. Dong Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry Anal Chim Acta 648 2009 98 104
33. R.A. Igal Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer Carcinogenesis 31 2010 1509 1515
34. V. Chajes, K. Hulten, A.L. Van Kappel Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden Int J Cancer 83 1999 585 590
35. F.S. Falvella, R.M. Pascale, M. Gariboldi Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats Carcinogenesis 23 2002 1933 1936
36. D.F. Calvisi, C. Wang, C. Ho Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma Gastroenterology 140 2011 1071 1083
37. A. Rodriguez-Rivera, M. Galicia-Moreno, K. Reyes-Gordillo Methyl palmitate prevents CCl(4)-induced liver fibrosis J Appl Toxicol 28 2008 1021 1026
38. G. Liu Stearoyl-CoA desaturase inhibitors: update on patented compounds Expert Opin Ther Pat 19 2009 1169 1191
39. P. Kant, M.A. Hull Excess body weight and obesity-the link with gastrointestinal and hepatobiliary cancer Nat Rev Gastroenterol Hepatol 8 2011 224 238
40. E.C. de Haas, S.F. Oosting, J.D. Lefrandt The metabolic syndrome in cancer survivors Lancet Oncol 11 2010 193 203
41. H. Cao, K. Gerhold, J.R. Mayers Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 134 2008 933 944