Determination of buprenorphine, fentanyl and LSD in whole blood by UPLC-MS-MS

Journal of Analytical Toxicology

Volumn 37, Issue 3, 2013, Pages 159-165

  Berg, Thomas ^a   Jørgenrud, Benedicte ^b   Strand, Dag Helge ^a  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM FORMATE; BUPRENORPHINE; FENTANYL; LYSERGIDE; METHANOL;

ARTICLE; BLOOD SAMPLING; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; PH; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AMMONIA; ANALGESICS, OPIOID; BUPRENORPHINE; CALIBRATION; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FENTANYL; FORENSIC TOXICOLOGY; FORMATES; HALLUCINOGENS; HUMANS; HYDROGEN-ION CONCENTRATION; LIMIT OF DETECTION; LIQUID-LIQUID EXTRACTION; LYSERGIC ACID DIETHYLAMIDE; METHYL ETHERS; NORWAY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY;

EID: 84875273011     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bkt005     Document Type: Article

References (47)

1. Jasinski, D.R., Pevnick, J.S., Griffith, J.D. (1978) Human pharmacology and abuse potential of the analgesic buprenorphine: A potential agent for treating narcotic addiction. Archives of General Psychiatry, 35, 501-516.
2. Sporer, K.A. (2004) Buprenorphine: A primer for emergency physicians. Annals of Emergency Medicine, 43, 580-584.
3. Walsh, S.L., Preston, K.L., Bigelow, G.E., Stitzer, M.L. (1995) Acute administration of buprenorphine in humans: partial agonist and blockade effects. Journal of Pharmacology and Experimental Therapeutics, 274, 361-372.
4. Cone, E.J., Gorodetzky, C.W., Yousefnejad, D., Buchwald, W.F., Johnson, R.E. (1984) The metabolism and excretion of buprenorphine in humans. Drug Metabolism and Disposition, 12, 577-581.
5. Iribarne, C., Picart, D., Dreano, Y., Bail, J.P., Berthou, F. (1997) Involvement of cytochrome P450 3A4 in N-dealkylation of buprenorphine in human liver microsomes. Life Science, 60, 1953-1964.
6. Chrubasik, J., Wust, H., Schulte-Monting, J., Thon, K., Zindler, M. (1988) Relative analgesic potency of epidural fentanyl, alfentanil, and morphine in treatment of postoperative pain. Anesthesiology, 68, 929-933.
7. Lichtor, J.L., Sevarino, F.B., Joshi, G.P., Busch, M.A., Nordbrock, E., Ginsberg, B. (1999) The relative potency of oral transmucosal fentanyl citrate compared with intravenous morphine in the treatment of moderate to severe postoperative pain. Anesthesia & Analgesia, 89, 732-738.
8. Labroo, R.B., Paine, M.F., Thummel, K.E., Kharasch, E.D. (1997) Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. Drug Metabolism and Disposition, 25, 1072-1080.
9. Giacomelli, S., Palmery, M., Romanelli, L., Cheng, C.Y., Silvestrini, B. (1998) Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro. Life Science, 63, 215-222.
10. Canezin, J., Cailleux, A., Turcant, A., Le, B.A., Harry, P., Allain, P. (2001) Determination of LSD and its metabolites in human biological fluids by high-performance liquid chromatography with electrospray tandem mass spectrometry. Journal of Chromatography B, 765, 15-27.
11. Klette, K.L., Anderson, C.J., Poch, G.K., Nimrod, A.C., ElSohly, M.A. (2000) Metabolism of lysergic acid diethylamide (LSD) to 2-oxo-3-hydroxy LSD (O-H-LSD) in human liver microsomes and cryopreserved human hepatocytes. Journal of Analytical Toxicology, 24, 550-556.
12. Passie, T., Halpern, J.H., Stichtenoth, D.O., Emrich, H.M., Hintzen, A. (2008) The pharmacology of lysergic acid diethylamide: A review. CNS Neuroscience & Therapeutics, 14, 295-314.
13. Bjork, M.K., Nielsen, M.K., Markussen, L.O., Klinke, H.B., Linnet, K. (2010) Determination of 19 drugs of abuse and metabolites in whole blood by high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 396, 2393-2401.
14. Chung, A., Hudson, J., McKay, G. (2009) Validated ultraperformance liquid chromatography-tandem mass spectrometry method for analyzing LSD, iso-LSD, nor-LSD, and O-H-LSD in blood and urine. Journal of Analytical Toxicology, 33, 253-259.
15. Coopman, V., Cordonnier, J., Pien, K., Van, V.D. (2007) LC-MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic transdermal therapeutic systems. Forensic Science International, 169, 223-227.
16. Favretto, D., Frison, G., Maietti, S., Ferrara, S.D. (2007) LC-ESI-MS/ MS on an ion trap for the determination of LSD, iso-LSD, nor-LSD and 2-oxo-3-hydroxy-LSD in blood, urine and vitreous humor. International Journal of Legal Medicine, 121, 259-265.
17. Johansen, S.S., Jensen, J.L. (2005) Liquid chromatography-tandem mass spectrometry determination of LSD, ISO-LSD, and the main metabolite 2-oxo-3-hydroxy-LSD in forensic samples and application in a forensic case. Journal of Chromatography B, 825, 21-28.
18. Oiestad, E.L., Johansen, U., Oiestad, A.M., Christophersen, A.S. (2011) Drug screening of whole blood by ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Analytical Toxicology, 35, 280-293.
19. Selden, T., Roman, M., Druid, H., Kronstrand, R. (2011) LC-MS-MS analysis of buprenorphine and norbuprenorphine in whole blood from suspected drug users. Forensic Science International, 209, 113-119.
20. Verplaetse, R., Tytgat, J. (2010) Development and validation of a sensitive ultra performance liquid chromatography tandem mass spectrometry method for the analysis of fentanyl and its major metabolite norfentanyl in urine and whole blood in forensic context. Journal of Chromatography B, 878, 1987-1996.
21. Verplaetse, R., Cuypers, E., Tytgat, J. (2012) The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of Chromatography A, 1249, 147-154.
22. Cooreman, S., Deprez, C., Martens, F., Van, B.J., Croes, K. (2010) A comprehensive LC-MS-based quantitative analysis of fentanyl-like drugs in plasma and urine. Journal of Separation Science, 33, 2654-2662.
23. Huynh, N.H., Tyrefors, N., Ekman, L., Johansson, M. (2005) Determination of fentanyl in human plasma and fentanyl and norfentanyl in human urine using LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis, 37, 1095-1100.
24. Ceccato, A., Klinkenberg, R., Hubert, P., Streel, B. (2003) Sensitive determination of buprenorphine and its N-dealkylated metabolite norbuprenorphine in human plasma by liquid chromatography coupled to tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 32, 619-631.
25. Ghassabian, S., Moosavi, S.M., Valero, Y.G., Shekar, K., Fraser, J.F., Smith, M.T. (2012) High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903, 126-133.
26. Polettini, A., Huestis, M.A. (2001) Simultaneous determination of buprenorphine, norbuprenorphine, and buprenorphineglucuronide in plasma by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 754, 447-459.
27. Badawi, N., Simonsen, K.W., Steentoft, A., Bernhoft, I.M., Linnet, K. (2009) Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and ultraperformance LC-MS/MS. Clinical Chemistry, 55, 2004-2018.
28. Lund, H.M., Oiestad, E.L., Gjerde, H., Christophersen, A.S. (2011) Drugs of abuse in oral fluid collected by two different sample kits-Stability testing and validation using ultra performance tandem mass spectrometry analysis. Journal of Chromatography B, 879, 3367-3377.
29. Oiestad, E.L., Johansen, U., Christophersen, A.S. (2007) Drug screening of preserved oral fluid by liquid chromatography-tandem mass spectrometry. Clinical Chemistry, 53, 300-309.
30. Guillarme, D., Nguyen, D.T., Rudaz, S., Veuthey, J.L. (2007) Method transfer for fast liquid chromatography in pharmaceutical analysis: Application to short columns packed with small particle. Part I: Isocratic separation. European Journal of Pharmaceutics and Biopharmaceutics, 66, 475-482.
31. Guillarme, D., Nguyen, D.T., Rudaz, S., Veuthey, J.L. (2008) Method transfer for fast liquid chromatography in pharmaceutical analysis: Application to short columns packed with small particle. Part II: Gradient experiments. European Journal of Pharmaceutics and Biopharmaceutics, 68, 430-440.
32. Novakova, L., Vlckova, H. (2009) A review of current trends and advances in modern bio-analytical methods: Chromatography and sample preparation. Analytica Chimica Acta, 656, 8-35.
33. Wren, S.A., Tchelitcheff, P. (2006) Use of ultra-performance liquid chromatography in pharmaceutical development. Journal of Chromatography A, 1119, 140-146.
34. Berg, T., Lundanes, E., Christophersen, A.S., Strand, D.H. (2009) Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. Journal of Chromatography B, 877, 421-432.
35. Gray, N., Musenga, A., Cowan, D.A., Plumb, R., Smith, N.W. (2011) A simple high pH liquid chromatography-tandem mass spectrometry method for basic compounds: application to ephedrines in doping control analysis. Journal of Chromatography A, 1218, 2098-2105.
36. Mess, J.N., Lahaie, M., Furtado, M., Garofolo, F. (2009) Effect of high pH mobile phase on the sensitivity of multiple drugs by LC positive electrospray ionization MS/MS. Bioanalysis, 1, 1419-1430.
37. Peng, L., Farkas, T. (2008) Analysis of basic compounds by reversedphase liquid chromatography-electrospray mass spectrometry in highpH mobile phases. Journal of Chromatography A, 1179, 131-144.
38. Verplaetse, R., Tytgat, J. (2012) Development and validation of a sensitive UPLC-MS/MS method for the analysis of narcotic analgesics in urine and whole blood in forensic context. Forensic Science International, 215, 136-145.
39. Annesley, T.M. (2003) Ion suppression in mass spectrometry. Clinical Chemistry, 49, 1041-1044.
40. Chambers, E. (2007) Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. Journal of Chromatography B, 852, 22-34.
41. Hopfgartner, G., Bourgogne, E. (2003) Quantitative highthroughput analysis of drugs in biological matrices by mass spectrometry. Mass Spectrometry Reviews, 22, 195-214.
42. Muller, C., Schafer, P., Stortzel, M., Vogt, S., Weinmann, W. (2002) Ion suppression effects in liquid chromatography-electrospray-ionisation transport-region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries. Journal of Chromatography B, 773, 47-52.
43. Pang, L.Q., Liang, Q.L., Wang, Y.M., Ping, L., Luo, G.A. (2008) Simultaneous determination and quantification of seven major phospholipid classes in human blood using normal-phase liquid chromatography coupled with electrospray mass spectrometry and the application in diabetes nephropathy. Journal of Chromatography B, 869, 118-125.
44. Little, J.L., Wempe, M.F., Buchanan, C.M. (2006) Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma. Journal of Chromatography B, 833, 219-230.
45. Xia, Y.Q., Jemal, M. (2009) Phospholipids in liquid chromatography/ mass spectrometry bioanalysis: Comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. Rapid Communications in Mass Spectrometry, 23, 2125-2138.
46. Vindenes, V., Jordbru, D., Knapskog, A.B., Kvan, K., Mathisrud, G., Slordal, L. et al. (2012) Impairment based legislative limits for driving under the influence of non-alcohol drugs in Norway. Forensic Science International, 219, 1.
47. Matuszewski, B.K., Constanzer, M.L., Chavez-Eng, C.M. (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Analytical Chemistry, 75, 3019-3030.