The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood

Journal of Chromatography A

Volumn 1249, Issue , 2012, Pages 147-154

  Verplaetse, Ruth ^a   Cuypers, Eva ^a   Tytgat, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Benzodiazepine; High pH mobile phase; LC MS MS; UFLC; UHPLC or UPLC

Indexed keywords

BENZODIAZEPINE; LC-MS/MS; MOBILE PHASE; UFLC; UHPLC OR UPLC;

AMMONIUM COMPOUNDS; ATMOSPHERIC PRESSURE; BLOOD; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; METHANOL;

MASS SPECTROMETRY;

7 AMINOFLUNITRAZEPAM; ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; BROTIZOLAM; CHLORDIAZEPOXIDE; CLOBAZAM; CLONAZEPAM; CLOTIAZEPAM; CLOXAZOLAM; DELORAZEPAM; DIAZEPAM; DRUG METABOLITE; ETHYLLOFLAZEPATE; FLUNITRAZEPAM; FLURAZEPAM; HYPNOTIC AGENT; LOPRAZOLAM; LORAZEPAM; LORMETAZEPAM; MIDAZOLAM; N METHYLCLONAZEPAM; NITRAZEPAM; NORDAZEPAM; NORFLUNITRAZEPAM; OXAZEPAM; PRAZEPAM; TEMAZEPAM; TETRAZEPAM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CATION EXCHANGE; CHEMICAL PARAMETERS; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HIGH PH MOBILE PHASE; INTERMETHOD COMPARISON; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID PHASE MICROEXTRACTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SIGNAL PROCESSING; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; VALIDATION PROCESS;

BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; HYPNOTICS AND SEDATIVES; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY;

EID: 84863775727     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.06.023     Document Type: Article

References (26)

1. Drummer O.H., Odell M. The Forensic Pathology of Drugs of Abuse 2001, Arnold, London, UK.
2. Nakamura M. Biomed. Chromatogr. 2011, 25:1283.
3. Verplaetse R., Tytgat J. TIAFT Bull. 2011, 41:8.
4. Polettini A. Applications of LC-MS in Toxicology 2006, Pharmaceutical Press, London, UK.
5. Kratzsch C., Tenberken O., Peters F.T., Weber A.A., Kraemer T., Maurer H.H. J. Mass Spectrom. 2004, 39:856.
6. Dussy F.E., Hamberg C., Briellmann T.A. Int. J. Legal Med. 2006, 120:323.
7. Remane D., Meyer M.R., Peters F.T., Wissenbach D.K., Maurer H.H. Anal. Bioanal. Chem. 2010, 397:2303.
8. Smink B.E., Brandsma J.E., Dijkhuizen A., Lusthof K.J., de Gier J.J., Egberts A.C., Uges D.R. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2004, 811:13.
9. Bugey A., Rudaz S., Staub C. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2006, 832:249.
10. Hegstad S., Oiestad E.L., Johansen U., Christophersen A.S. J. Anal. Toxicol. 2006, 30:31.
11. Verplaetse R., Tytgat J. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2010, 878:1987.
12. Berg T., Lundanes E., Christophersen A.S., Strand D.H. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2009, 877:421.
13. Peng L., Farkas T. J. Chromatogr. A 2008, 1179:131.
14. Virus E.D., Sobolevsky T.G., Rodchenkov G.M. J. Mass Spectrom. 2011, 47:381.
15. Verplaetse R., Tytgat J. Forensic Sci. Int. 2012, 215:136.
16. Delatour C., Leclerq L. Rapid Commun. Mass Spectrom. 2005, 19:1359.
17. Blas M., McCord B.R. Electrophoresis 2008, 29:2182.
18. Bruins A. J. Chromatogr. A 1998, 794:345.
19. Wood M., Laloup M., Ramirez Fernandez Mdel M., Jenkins K.M., Young M.S., Ramaekers J.G., De Boeck G., Samyn N. Forensic Sci. Int. 2005, 150:227.
20. Pichini S., Pujadas M., Marchei E., Pellegrini M., Fiz J., Pacifici R., Zuccaro P., Farre M., de la Torre R. J. Pharm. Biomed. Anal. 2008, 47:335.
21. Chen X.H., Franke J.P., Wijsbeek J., de Zeeuw R.A. J. Anal. Toxicol. 1992, 16:351.
22. Shanlin F., Molnar A., Bowron P., Wang H., Dawson M., Lewis J.H. TIAFT Bull. 2011, 41:58.
23. Quintela O., Sauvage F.L., Charvier F., Gaulier J.M., Lachatre G., Marquet P. Clin. Chem. 2006, 52:1346.
24. Regenthal R., Krueger M., Koeppel C., Preiss R. J. Clin. Monit. Comput. 1999, 15:529.
25. Baselt R.C. Disposition of Toxic Drugs and Chemicals in Man 2011, Chemical Toxicology Institute, Foster City, CA.
26. Cautreels W., Jeanniot J.P. Biomed. Mass Spectrom. 1980, 7:565.