The role of mitochondria and biotransformation in abamectin-induced cytotoxicity in isolated rat hepatocytes

Toxicology in Vitro

Volumn 27, Issue 2, 2013, Pages 570-579

  Maioli, Marcos A ^a   de Medeiros, Hyllana C D ^a   Guelfi, Marieli ^a   Trinca, Vitor ^a   Pereira, Flávia T V ^a   Mingatto, Fábio E ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Abamectin; ATP; Calcium; Hepatotoxicity; Necrosis

Indexed keywords

ABAMECTIN; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CASPASE 3; CYTOCHROME C; GLUTAMIC ACID; MALIC ACID; PROADIFEN; SUCCINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; BIOTRANSFORMATION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL DEATH; CELL ISOLATION; CELL LEVEL; CELL RESPIRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; LIVER CELL; LIVER METABOLISM; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXYGEN CONSUMPTION; RAT; TOXICOKINETICS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTHELMINTICS; BIOTRANSFORMATION; CALCIUM; CASPASE 3; CELL RESPIRATION; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; HEPATOCYTES; IVERMECTIN; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; NECROSIS; OXYGEN CONSUMPTION; RATS; RATS, WISTAR;

EID: 84875264776     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.10.017     Document Type: Article

References (51)

1. Agarwal A.K. Avermectin. Encyclopedia of Toxicology 1998, 89-90. Academic Press, San Diego. P. Wexler (Ed.).
2. Appaix F., Minatchy M.N., Riva-Lavieille C., Olivares J., Antonsson B., Saks V.A. Rapid spectrophotometric method for quantification of cytochrome c release from isolated mitochondria or permeabilizaed cells revisited. Biochim. Biophys. Acta 2000, 1457:175-181.
3. Barros L.F., Kanaseki T., Sabirov R., Morishima S., Castro J., Bittiner C.X., Maeno E., Ando-Akatsuka Y., Okada Y. Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency. Cell Death Differ. 2003, 10:687-697.
4. Bort R., Ponsoda X., Jover R., Gómez-Lechón M.J., Castell J.V. Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J. Pharmacol. Exp. Ther. 1998, 288:65-72.
5. Brookes P.S., Yoon Y., Robotham J.L., Anders M.W., Sheu S.S. Calcium, ATP and ROS: a mitochondrial love-hate triangle. Am. J. Physiol. 2004, 287:C817-C833.
6. Burg R.W., Miller B.M., Baker E.E., Birnbaum J., Currie S.A., Hartman R., Kong Y.L., Monaghan R.L., Olson G., Putter I., Tunac J.B., Wallick H., Stapley E.O., Oiwa R., Omura S. Avermectins, new family of potent anthelmintic agents: producting organism and fermentation. Antimicrob. Agents Chemother. 1979, 15:361-367.
7. Castanha Zanoli J.C., Maioli M.A., Medeiros H.C.D., Mingatto F.E. Abamectin affects the bioenergetics of liver mitochondria: a potential mechanism of hepatotoxicity. Toxicol. In Vitro 2012, 26:51-56.
8. Eguchi Y., Shimizu S., Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 1997, 57:1835-1840.
9. Elbetieha A., Daas S.I. Assessment of antifertility activities of ABM pesticide in male rats. Ecotoxicol. Environ. Saf. 2003, 55:307-313.
10. El-Shenawy N.S. Effects of insecticides fenitrothion, endosulfan and abamectin on antioxidant parameters of isolated rat hepatocytes. Toxicol. In Vitro 2010, 24:1148-1157.
11. Fisher M.H., Mrozik H. Chemistry. Ivermectin and Abamectin 1989, 1-23. Springer-Verlag, New York. W.C. Campbell (Ed.).
12. Gores G.J., Hermans B., Lemasters J.J. Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury. Hepatology 1990, 11:690-698.
13. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
14. Grisham J.W. Use of hepatic cell cultures to detect and evaluate the mechanisms of action of toxic chemicals. Int. Rev. Exp. Pathol. 1979, 20:123-209.
15. Grisham J.W., Smith G.J. Predictive and mechanistic evaluation of toxic responses in mammalian cell culture systems. Pharmacol. Rev. 1984, 36:151S-171S.
16. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260:3440-3450.
17. Guguen-Guillouzo C. Isolation and culture of animal and human hepatocytes. Culture of Epithelial Cells 1992, 197-223. Wiley-Liss, New York. R.I. Freshney (Ed.).
18. Hatefi Y. ATP synthesis in mitochondria. Eur. J. Biochem. 1993, 218:759-767.
19. Hayes W.J., Laws E.R. Handbook of Pesticide Toxicology Classes of Pesticides 1990, Academic Press Inc., New York. first ed.
20. Hsu D.Z., Hsu C.H., Huang B.M., Liu M.Y. Abamectin effects on aspartate aminotransferase and nitric oxide in rats. Toxicology 2001, 165:189-193.
21. Ioannides C., Lewis D.F.V. Cytochromes P450 in the bioactivation of chemicals. Curr. Top. Med. Chem. 2004, 4:1767-1788.
22. Kaplowitz N. Drug-induced liver disorders implications for drug development and regulation. Drug Saf. 2001, 24:483-490.
23. Kass G.E., Eriksson J.E., Weis M., Orrenius S., Chow S.C. Chromatin condensation during apoptosis requires ATP. Biochem. J. 1996, 318:749-752.
24. Khan S., Sood C., O'Brien P.J. Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes. Biochem. Pharmacol. 1993, 45:439-447.
25. Klaassen C.D., Eaton D.L. Principles of toxicology. Toxicology 1991, 12-49. McGraw-Hill, New York. fourth ed. M.O. Amdur, J. Doull, C.D. Klaassen (Eds.).
26. Lankas G.R., Gordon L.R. Toxicology. Ivermectin and Abamectin 1989, 102-107. Springer-Verlag, Nova York. W.C. Campbell (Ed.).
27. Lemasters J.J., Qian T., Bradham C.A., Brenner D.A., Cascio W.E., Trost L.C., Nishimura Y., Nieminen A.L., Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J. Bioenerg. Biomembr. 1999, 31:305-319.
28. Lowenstein M., Loupal G., Baumgartner W., Kutzer E. Histology of the skin and determination of blood and serum parameters during the recovery phase of sarcoptic manage in cattle after avermectin (Ivomec) treatment. Appl. Parasitol. 1996, 37:77-86.
29. Maioli M.A., Alves L.C., Perandin D., Garcia A.F., Pereira F.T.V., Mingatto F.E. Cytotoxicity of monocrotaline in isolated rat hepatocytes: effects of dithiothreitol and fructose. Toxicon 2011, 57:1057-1064.
30. Meister R.T. Farm Chemicals Handbook '92 1992, Meister Publishing Company, Willoughby, Ohio.
31. Meyer S.A., Kulkarni A.P. Hepatotoxicity. Introduction to Biochemical Toxicology 2001, 487-507. John Wiley & Sons, New York. third ed. E. Hodgson, R.C. Smart (Eds.).
32. Mingatto F.E., Dorta D.J., Santos A.B., Carvalho I., Silva C.H.T.P., Silva V.B., Uyemura S.A., Santos A.C., Curti C. Dehydromonocrotaline inhibits mitochondrial complex I. A potential mechanism accounting for hepatotoxicity of monocrotaline. Toxicon 2007, 50:724-730.
33. Mingatto F.E., Rodrigues T., Pigoso A.A., Uyemura S.A., Curti C., Santos A.C. The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes. J. Pharmacol. Exp. Ther. 2002, 303:601-607.
34. Molinari G., Soloneski S., Larramendy M.L. New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin. Cytogenet. Genome Res. 2010, 128:37-45.
35. Moreadith R.W., Fisckum G. Isolation of mitochondria from ascites tumor cells permeabilized with digitonina. Anal. Biochem. 1984, 137:360-367.
36. 2+ is mediated by the activation of a nonlysosomal proteolytic system. FEBS Lett. 1986, 209:139-144.
37. Nicotera P., Leist M., Ferrando-Mey E. Intracellular ATP, a switch in the decision between apoptosis and necrosis. Toxicol. Lett. 1998, 102-103:139-142.
38. Oliveira P.J., Wallace K.B. Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats. Relevance for mitochondrial dysfunction. Toxicology 2006, 220:160-168.
39. Oga S. Fundamentos de toxicologia 2008, Atheneu, São Paulo. third ed.
40. Pedersen P.L. Frontiers in ATP synthase research: understanding the relationship between subunit movements and ATP synthesis. J. Bioenerg. Biomembr. 1996, 28:389-395.
41. 2+ homeostasis in cultured rat hepatocytes intoxicated with cyanide. Am. J. Physiol. 1992, 263:C684-C690.
42. Shoop W., Mrozik H., Fisher M. Structure and activity of avermectins and milbemycins in animal health. Vet. Parasitol. 1995, 59:139-156.
43. Skulachev V.P. Mitochondrial physiology and pathology: concepts of programmed death of organelles, cells and organisms. Mol. Aspects Med. 1999, 20:139-184.
44. Somchit N., Ngee C.S., Yaakob A., Ahmad Z., Zakaria Z.A. Effects of cytochrome P450 inhibitors on itraconazole and fluconazole induced cytotoxicity in hepatocytes. J. Toxicol. 2009, 2009:1-7.
45. Shi Q., Yang X., Greenhaw J., Salminen W.F. Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. Toxicol. Sci. 2011, 122:579-586.
46. Szewczyk A., Wojtczak L. Mitochondria as a pharmacological target. Pharmacol. Rev. 2002, 54:101-127.
47. 2+ in cell injury, necrosis and apoptosis. Curr. Opin. Cell Biol. 1992, 4:227-232.
48. Tsujimoto Y. Apoptosis and necrosis: Intracellular ATP level as a determinant for cell death modes. Cell Death Differ. 1997, 4:429-434.
49. Turner M.J., Schaeffer J.M. Mode of action of ivermectin. Ivermectin and Abamectin 1989, 73-88. Springer Verlag, New York. W.C. Campbell (Ed.).
50. Wallace K.B., Starkov A.A. Mitochondrial targets of drug toxicity. Annu. Rev. Pharmacol. Toxicol. 2000, 40:353-388.
51. Zeng Z., Andrew N.W., Woda J.M., Halley B.A., Crouch L.S., Wang R.W. Role of cytochrome P450 isoforms in the metabolism of abamectin and ivermectin in rats. J. Agric. Food Chem. 1996, 44:3374-3378.