Cerebral endothelial expression of Robo1 affects brain infiltration of polymorphonuclear neutrophils during mouse stroke recovery

Neurobiology of Disease

Volumn 54, Issue , 2013, Pages 24-31

  Gangaraju, Sandhya ^a   Sultan, Khadeejah ^a   Whitehead, Shawn N ^a   Nilchi, Ladan ^a   Slinn, Jacqueline ^a   Li, Xuesheng ^a,b   Hou, Sheng T ^a,b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

HUVEC cells; PMN; Repulsive; Robo1; Slit1; Stroke recovery; Transwell

Indexed keywords

GLUCOSE; OXYGEN; RECEPTOR PROTEIN; ROBO1 PROTEIN; SLIT PROTEIN; SLIT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN TISSUE; CELL MIGRATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CONVALESCENCE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; SHAM PROCEDURE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; BLOTTING, WESTERN; BRAIN; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HEK293 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEUTROPHILS; RECEPTORS, IMMUNOLOGIC; STROKE; TRANSFECTION;

EID: 84875250778     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.02.014     Document Type: Article

References (23)

1. Abbott N.J., Friedman A. Overview and introduction: the blood-brain barrier in health and disease. Epilepsia 2012, 53(Suppl. 6):1-6.
2. Abulrob A., et al. Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging. Mol. Imaging 2008, 7:248-262.
3. Brose K., et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 1999, 96:795-806.
4. Carmeliet P., Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature 2005, 436:193-200.
5. Hou S.T., et al. Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. J. Neurosci. 2006, 26:2241-2249.
6. Hou S.T., et al. Sustained up-regulation of semaphorin 3A, Neuropilin1, and doublecortin expression in ischemic mouse brain during long-term recovery. Biochem. Biophys. Res. Commun. 2008, 367:109-115.
7. Hou S.T., et al. Neuropilin 2 deficiency does not affect cortical neuronal viability in response to oxygen-glucose-deprivation and transient middle cerebral artery occlusion. Neurosci. Res. 2010, 66:396-401.
8. Huang J., et al. Inflammation in stroke and focal cerebral ischemia. Surg. Neurol. 2006, 66:232-245.
9. Jin A.Y., et al. Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke. BMC Neurosci. 2010, 11:12.
10. Kidd T., et al. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell 1998, 92:205-215.
11. Kiernan J.A. Histological and Histochemical Methods: Theory and Practice 1999, Butterworth-Heinemann, Oxford. third ed.
12. Latour L.L., et al. Early blood-brain barrier disruption in human focal brain ischemia. Ann. Neurol. 2004, 56:468-477.
13. Liesz A., et al. Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain 2011, 134:704-720.
14. Neuwelt E.A., et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat. Rev. Neurosci. 2011, 12:169-182.
15. Paschen W., et al. Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance. Curr. Pharm. Des. 2007, 13:1887-1902.
16. Preston E., et al. Graded reversible opening of the rat blood-brain barrier by intracarotid infusion of sodium caprate. J. Neurosci. Methods 2008, 168:443-449.
17. Rosell A., et al. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke 2008, 39:1121-1126.
18. Rothberg J.M., et al. Slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev. 1990, 4:2169-2187.
19. Seeger M., et al. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 1993, 10:409-426.
20. Tole S., et al. The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils. J. Leukoc. Biol. 2009, 86:1403-1415.
21. Whitehead S.N., et al. Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery. PLoS One 2011, 6:e20808.
22. Wong K., et al. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 2001, 107:209-221.
23. Wong K., et al. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr. Opin. Genet. Dev. 2002, 12:583-591.