Neuropilin 2 deficiency does not affect cortical neuronal viability in response to oxygen-glucose-deprivation and transient middle cerebral artery occlusion

Neuroscience Research

Volumn 66, Issue 4, 2010, Pages 396-401

  Hou, Sheng T ^a,b   Jiang, Susan X ^a   Slinn, Jacqueline ^a   O'Hare, Michael ^a   Karchewski, Laurie ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Axonal guidance; Cerebral ischemia; MCAO; Neuropilin; NRP2; Oxygen glucose deprivation; Stroke

Indexed keywords

NEUROPILIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CELL; BRAIN CORTEX; BRAIN DAMAGE; BRAIN INFECTION; BRAIN ISCHEMIA; CELL VIABILITY; CONTROLLED STUDY; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROKE;

ANIMALS; BRAIN INFARCTION; CELL SURVIVAL; CEREBRAL CORTEX; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MICE; MICE, KNOCKOUT; NEURONS; NEUROPILIN-2; OXYGEN;

EID: 77049102373     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2009.12.010     Document Type: Article

References (36)

1. Acevedo L.M., Barillas S., Weis S.M., Gothert J.R., and Cheresh D.A. Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. Blood 111 (2008) 2674-2680
2. Bannerman P., Ara J., Hahn A., Hong L., McCauley E., Friesen K., and Pleasure D. Peripheral nerve regeneration is delayed in neuropilin 2-deficient mice. J. Neurosci. Res. 86 (2008) 3163-3169
3. Beck H., Acker T., Puschel A.W., Fujisawa H., Carmeliet P., and Plate K.H. Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling. J. Neuropathol. Exp. Neurol. 61 (2002) 339-350
4. Carmichael S.T., Archibeque I., Luke L., Nolan T., Momiy J., and Li S. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Exp. Neurol. 193 (2005) 291-311
5. Chen H., Bagri A., Zupicich J.A., Zou Y., Stoeckli E., Pleasure S.J., Lowenstein D.H., Skarnes W.C., Chedotal A., and Tessier-Lavigne M. Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron 25 (2000) 43-56
6. Chen H., Chedotal A., He Z., Goodman C.S., and Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 19 (1997) 547-559
7. Gant J.C., Thibault O., Blalock E.M., Yang J., Bachstetter A., Kotick J., Schauwecker P.E., Hauser K.F., Smith G.M., Mervis R., Li Y., and Barnes G.N. Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. Epilepsia 50 (2009) 629-645
8. Giger R.J., Cloutier J.F., Sahay A., Prinjha R.K., Levengood D.V., Moore S.E., Pickering S., Simmons D., Rastan S., Walsh F.S., Kolodkin A.L., Ginty D.D., and Geppert M. Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron 25 (2000) 29-41
9. Gu C., Limberg B.J., Whitaker G.B., Perman B., Leahy D.J., Rosenbaum J.S., Ginty D.D., and Kolodkin A.L. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J. Biol. Chem. 277 (2002) 18069-18076
10. Gu C., Rodriguez E.R., Reimert D.V., Shu T., Fritzsch B., Richards L.J., Kolodkin A.L., and Ginty D.D. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 5 (2003) 45-57
11. He Z., and Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90 (1997) 739-751
12. Hou S.T., Callaghan D., Fournier M.C., Hill I., Kang L., Massie B., Morley P., Murray C., Rasquinha I., Slack R., and MacManus J.P. The transcription factor E2F1 modulates apoptosis of neurons. J. Neurochem. 75 (2000) 91-100
13. Hou S.T., Jiang S.X., and Smith R.A. Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration. Int. Rev. Cell Mol. Biol. 267 (2008) 125-181
14. Hou S.T., Keklikian A., Slinn J., O'Hare M., Jiang S.X., and Aylsworth A. Sustained up-regulation of semaphorin 3A, Neuropilin1, and doublecortin expression in ischemic mouse brain during long-term recovery. Biochem. Biophys. Res. Commun. 367 (2008) 109-115
15. Hou S.T., Tu Y., Buchan A.M., Huang Z., Preston E., Rasquinha I., Robertson G.S., and MacManus J.P. Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia. Biochem. Cell Biol. 75 (1997) 383-392
16. Jiang S.X., Lertvorachon J., Hou S.T., Konishi Y., Webster J., Mealing G., Brunette E., Tauskela J., and Preston E. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J. Biol. Chem. 280 (2005) 33811-33818
17. Jiang S.X., Sheldrick M., Desbois A., Slinn J., and Hou S.T. Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo. Mol. Cell. Biol. 27 (2007) 1696-1705
18. Kaneko S., Iwanami A., Nakamura M., Kishino A., Kikuchi K., Shibata S., Okano H.J., Ikegami T., Moriya A., Konishi O., Nakayama C., Kumagai K., Kimura T., Sato Y., Goshima Y., Taniguchi M., Ito M., He Z., Toyama Y., and Okano H. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nat. Med. 12 (2006) 1380-1389
19. Kikuchi K., Kishino A., Konishi O., Kumagai K., Hosotani N., Saji I., Nakayama C., and Kimura T. In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J. Biol. Chem. 278 (2003) 42985-42991
20. Kitsukawa T., Shimizu M., Sanbo M., Hirata T., Taniguchi M., Bekku Y., Yagi T., and Fujisawa H. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 19 (1997) 995-1005
21. Kitsukawa T., Shimono A., Kawakami A., Kondoh H., and Fujisawa H. Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 121 (1995) 4309-4318
22. Kolodkin A.L., Levengood D.V., Rowe E.G., Tai Y.T., Giger R.J., and Ginty D.D. Neuropilin is a semaphorin III receptor. Cell 90 (1997) 753-762
23. Kumagai K., Hosotani N., Kikuchi K., Kimura T., and Saji I. Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium. J. Antibiot. (Tokyo) 56 (2003) 610-616
24. Li S., and Carmichael S.T. Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke. Neurobiol. Dis. 23 (2006) 362-373
25. MacManus J.P., Koch C.J., Jian M., Walker T., and Zurakowski B. Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1. Neuroreport 10 (1999) 2711-2714
26. O'Hare M.J., Hou S.T., Morris E.J., Cregan S.P., Xu Q., Slack R.S., and Park D.S. Induction and modulation of cerebellar granule neuron death by E2F-1. J. Biol. Chem. 275 (2000) 25358-25364
27. Pasterkamp R.J., and Giger R.J. Semaphorin function in neural plasticity and disease. Curr. Opin. Neurobiol. 19 (2009) 263-274
28. Preston E., and Webster J. Spectrophotometric measurement of experimental brain injury. J. Neurosci. Methods 94 (2000) 187-192
29. Scarlato M., Ara J., Bannerman P., Scherer S., and Pleasure D. Induction of neuropilins-1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system. Exp. Neurol. 183 (2003) 489-498
30. Shen J., Samul R., Zimmer J., Liu H., Liang X., Hackett S., and Campochiaro P.A. Deficiency of neuropilin 2 suppresses VEGF-induced retinal neovascularization. Mol. Med. 10 (2004) 12-18
31. Shirvan A., Kimron M., Holdengreber V., Ziv I., Ben Shaul Y., Melamed S., Melamed E., Barzilai A., and Solomon A.S. Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy. J. Biol. Chem. 277 (2002) 49799-49807
32. Shirvan A., Ziv I., Fleminger G., Shina R., He Z., Brudo I., Melamed E., and Barzilai A. Semaphorins as mediators of neuronal apoptosis. J. Neurochem. 73 (1999) 961-971
33. Sun Y., Jin K., Childs J.T., Xie L., Mao X.O., and Greenberg D.A. Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. J. Cereb. Blood Flow Metab. 24 (2004) 1146-1152
34. Sun Y., Jin K., Xie L., Childs J., Mao X.O., Logvinova A., and Greenberg D.A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111 (2003) 1843-1851
35. Weaver J.G., Tarze A., Moffat T.C., Lebras M., Deniaud A., Brenner C., Bren G.D., Morin M.Y., Phenix B.N., Dong L., Jiang S.X., Sim V.L., Zurakowski B., Lallier J., Hardin H., Wettstein P., van Heeswijk R.P., Douen A., Kroemer R.T., Hou S.T., Bennett S.A., Lynch D.H., Kroemer G., and Badley A.D. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. J. Clin. Invest. 115 (2005) 1828-1838
36. Zhang Z.G., Tsang W., Zhang L., Powers C., and Chopp M. Up-regulation of neuropilin-1 in neovasculature after focal cerebral ischemia in the adult rat. J. Cereb. Blood Flow Metab. 21 (2001) 541-549