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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2035-2043

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

(16) Cheng, Gang a Muench, Stephen P b Zhou, Ying c Afanador, Gustavo A d Mui, Ernest J c Fomovska, Alina c Lai, Bo Shiun c Prigge, Sean T d Woods, Stuart e Roberts, Craig W e Hickman, Mark R g Lee, Patty J g Leed, Susan E g Auschwitz, Jennifer M g Rice, David W f McLeod, Rima c

a UNIVERSITY OF ILLINOIS AT CHICAGO (United States)

b UNIVERSITY OF LEEDS (United Kingdom)

c UNIVERSITY OF CHICAGO (United States)

d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH (United States)

e UNIVERSITY OF STRATHCLYDE (United Kingdom)

f UNIVERSITY OF SHEFFIELD (United Kingdom)

g WALTER REED ARMY INSTITUTE OF RESEARCH (United States)

Author keywords

ADMET; TgENR; Toxoplasma; Triclosan

Indexed keywords

DIARYL ETHER INHIBITOR; TRICLOSAN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TOXOPLASMA GONDII;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TOXOPLASMA; TRICLOSAN;

TOXOPLASMA; TOXOPLASMA GONDII;

EID: 84875231794 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.02.019 Document Type: Article

Times cited : (21)

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