Severe congenital toxoplasmosis in the United States: Clinical and serologic findings in untreated infants

Pediatric Infectious Disease Journal

Volumn 30, Issue 12, 2011, Pages 1056-1061

  Olariu, Tudor Rares ^a,b   Remington, Jack S ^a,b   McLeod, Rima ^c,d   Alam, Ambereen ^c,d   Montoya, Jose G ^a,b  

^a PALO ALTO MEDICAL FOUNDATION   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

clinical findings; congenital; infants; laboratory diagnosis; serologic findings; toxoplasma; toxoplasmosis

Indexed keywords

IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ARTICLE; BRAIN CALCIFICATION; CLINICAL FEATURE; CONGENITAL TOXOPLASMOSIS; DISEASE SEVERITY; EYE DISEASE; FEMALE; HUMAN; HYDROCEPHALUS; INFANT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PRIORITY JOURNAL; SEROLOGY; UNITED STATES;

ANTIBODIES, PROTOZOAN; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INFANT; INFANT, NEWBORN; MALE; POLYMERASE CHAIN REACTION; TOXOPLASMA; TOXOPLASMOSIS, CONGENITAL; UNITED STATES;

EID: 81855175387     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3182343096     Document Type: Article

References (36)

1. Remington JS, McLeod R, Thuilliez P, et al. Toxoplasmosis. In: Remington JS, Klein JO, Wilson CB, et al, eds. Infectious Diseases of the Fetus and Newborn Infant. 7th ed. Philadelphia, PA: Elsevier Saunders; 2011.
2. Boyer KM, Holfels E, Roizen N, et al. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening. Am J Obstet Gynecol. 2005;192: 564-571. (Pubitemid 40214997)
3. Cook AJ, Gilbert RE, Buffolano W, et al. Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. BMJ. 2000;321:142-147. (Pubitemid 30447005)
4. Jones JL, Dargelas V, Roberts J, et al. Risk factors for Toxoplasma gondii infection in the United States. Clin Infect Dis. 2009;49:878-884.
5. Roberts T, Frenkel JK. Estimating income losses and other preventable costs caused by congenital toxoplasmosis in people in the United States. J Am Vet Med Assoc. 1990;196:249-256.
6. Naessens A, Jenum PA, Pollak A, et al. Diagnosis of congenital toxoplasmosis in the neonatal period. A multicenter evaluation. J Infect Dis. 1999;181:2018-2022.
7. Montoya JG. Laboratory diagnosis of Toxoplasma gondii infection and toxoplasmosis. J Infect Dis. 2002;185(suppl 1):S73-S82. (Pubitemid 34142832)
8. Grover CM, Thulliez P, Remington JS, et al. Rapid prenatal diagnosis of congenital Toxoplasma infection by using polymerase chain reaction and amniotic fluid. J Clin Microbiol. 1990;28:2297-2301. (Pubitemid 20299125)
9. Eichenwald HF. A study of congenital toxoplasmosis, with particular emphasis on clinical manifestations, sequelae and therapy. In: Siim JC, ed. Human Toxoplasmosis. Copenhagen, Denmark: Munksgaard; 1960:41.
10. McAuley J, Boyer KM, Patel D, et al. Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clin Inf Dis. 1994;18:38-72. (Pubitemid 24025917)
11. Guerina N, Hsu H-W, Meissner H, et al. Neonatal serologic screening and early treatment for congenital Toxoplasma gondii infection. N Engl J Med. 1994;330:1858-1863. (Pubitemid 24188138)
12. Dunn D, Wallon M, Peyron F, et al. Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet. 1999;353: 1829-1833. (Pubitemid 29251014)
13. Thiebaut R, Leproust S, Chene G, et al. Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' data. Lancet. 2007;369:115-122.
14. Kieffer F, Rigourd V, Ikounga P, et al. Disseminated congenital toxoplasma infection with a type II strain. Pediatr Infect Dis J. 2011;30:813-815.
15. Daffos F, Forestier F, Capella-Pavlovsky M, et al. Prenatal management of 746 pregnancies at risk for congenital toxoplasmosis. N Engl J Med. 1988;318:271-275. (Pubitemid 18034517)
16. Hohlfeld P, Daffos F, Costa J-M, et al. Prenatal diagnosis of congenital toxoplasmosis with polymerase-chain-reaction test on amniotic fluid. N Engl J Med. 1994;331:695-699.
17. Kieffer F, Wallon M, Garcia P, et al. Risk factors for retinochoroiditis during the first 2 years of life in infants with treated congenital toxoplasmosis. Pediatr Infect Dis J. 2008;27:27-32.
18. Thulliez P. Screening programme for congenital toxoplasmosis in France. Scand J Infect Dis Suppl. 1992;84:43-45. (Pubitemid 23048972)
19. Wallon M, Kodjikian L, Binquet C, et al. Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Pediatrics. 2004;113:1567-1572. (Pubitemid 38697960)
20. Couvreur J, Desmonts G. Congenital and maternal toxoplasmosis. A review of 300 congenital cases. Dev Med Child Neurol. 1962;4:519-530.
21. Desmonts G, Couvreur J. Congenital toxoplasmosis. A prospective study of 378 pregnancies. N Engl J Med. 1974;290:1110-1116.
22. Jamieson SE, de Roubaix LA, Cortina-Borja M, et al. Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis. PLoS One. 2008;3:e2285.
23. Romand S, Chosson M, Franck J, et al. Usefulness of quantitative polymerase chain reaction in amniotic fluid as early prognostic marker of fetal infection with Toxoplasma gondii. Am J Obstet Gynecol. 2004;190:797-802. (Pubitemid 38406796)
24. Ajzenberg D, Cogne N, Paris L, et al. Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings. J Infect Dis. 2002;186:684-689. (Pubitemid 34925541)
25. Elbez-Rubinstein A, Ajzenberg D, Darde ML, et al. Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review. J Infect Dis. 2009;199:280-285.
26. Decoster A, Gontier P, Dhecq E, et al. Detection of anti-toxoplasma immunoglobulin A antibodies by platelia-toxo IgA directed against P30 and by IMx toxo IgA for diagnosis of acquired and congenital toxoplasmosis. J Clin Microbiol. 1995;33:2206-2208.
27. Pinon JM, Chemla C, Villena I, et al. Early neonatal diagnosis of congenital toxoplasmosis: value of comparative enzyme-linked immunofiltration assay immunological profiles and anti-Toxoplasma gondii immunoglobulin m (IgM) or IgA immunocapture and implications for postnatal therapeutic strategies. J Clin Microbiol. 1996;34:579-583.
28. Wallon M, Dunn D, Slimani D, et al. Diagnosis of congenital toxoplasmosis at birth: what is the value of testing for IgM and IgA? Eur J Pediatr. 1999;158:645-649. (Pubitemid 29331033)
29. Villena I, Aubert D, Brodard V, et al. Detection of specific immunoglobulin e during maternal, fetal, and congenital toxoplasmosis. J Clin Microbiol. 1999;37:3487-3490. (Pubitemid 29491079)
30. Foudrinier F, Villena I, Jaussaud R, et al. Clinical value of specific immunoglobulin E detection by enzyme-linked immunosorbent assay in cases of acquired and congenital toxoplasmosis. J Clin Microbiol. 2003;41:1681-1686. (Pubitemid 36428117)
31. Labalette P, Delhaes L, Margaron F, et al. Ocular toxoplasmosis after the fifth decade. Am J Ophthalmol. 2002;133:506-515. (Pubitemid 34258059)
32. Portela RW, Bethony J, Costa MI, et al. A multihousehold study reveals a positive correlation between age, severity of ocular toxoplasmosis, and levels of glycoinositolphospholipid-specific immunoglobulin A. J Infect Dis. 2004;190:175-183. (Pubitemid 38858419)
33. Romand S, Wallon M, Franck J, et al. Prenatal diagnosis using polymerase chain reaction on amniotic fluid for congenital toxoplasmosis. Obstet Gynecol. 2001;97:296-300. (Pubitemid 32126349)
34. Wallon M, Franck J, Thulliez P, et al. Accuracy of real-time polymerase chain reaction for Toxoplasma gondii in amniotic fluid. Obstet Gynecol. 2010;115:727-733.
35. Hohlfeld P, Daffos F, Thulliez P, et al. Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J Pediatr. 1989; 115:765-769. (Pubitemid 19270273)
36. Cortina-Borja M, Tan HK, Wallon M, et al. Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: an observational prospective cohort study. PLoS Med. 2010;7(. pii):e1000351.