Pterostilbene induces mitochondrially derived apoptosis in breast cancer cells in vitro

Journal of Surgical Research

Volumn 180, Issue 2, 2013, Pages 208-215

  Moon, Dora ^a   McCormack, Denise ^a   McDonald, Debbie ^a   McFadden, David ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

Apoptosis; Bax; Bcl 2; Breast cancer; Cancer; Cytochrome C; MCF 7; MDA MB 131; Mitochondrial; Pterostilbene

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 3,5 DIMETHOXY 4 HYDROXYSTILBENE; ANTINEOPLASTIC AGENT; CALCIUM; CYTOCHROME C; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN BAX; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SMALL INTERFERING RNA; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL LYSATE; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA HISTONE INTERACTION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; IN VITRO STUDY; MICROSCOPE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RATIOMETRIC MONOCHROMATOR MICROSCOPE;

ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CALCIUM; CELL LINE, TUMOR; CYTOCHROMES C; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; STILBENES; SUPEROXIDE DISMUTASE;

EID: 84875226983     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.04.027     Document Type: Article

References (26)

1. M.G. Daidone, A. Luisi, and S. Veneroni Clinical studies of Bcl-2 and treatment benefit in breast cancer patients Endocr Relat Cancer 6 1999 61
2. Z.N. Oltvai, C.L. Milliman, and S.J. Korsmeyer Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74 1993 609
3. S. Krajewski, M. Krajewska, and B.C. Turner Prognostic significance of apoptosis regulators in breast cancer Endocr Relat Cancer 6 1999 29
4. S. Orrenius, B. Zhivotovsky, and P. Nicotera Regulation of cell death: The calcium-apoptosis link Nat Rev Mol Cell Biol 4 2003 552
5. P.W. Mannal, J.A. Alosi, and J.G. Schneider Pterostilbene inhibits pancreatic cancer in vitro J Gastrointest Surg 14 2010 873
6. J.G. Schneider, J.A. Alosi, and D.E. McDonald Effects of pterostilbene on melanoma alone and in synergy with inositol hexaphosphate Am J Surg 198 2009 679
7. J.A. Alosi, D.E. McDonald, and J.S. Schneider Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis J Surg Res 161 2010 195
8. T.E. Fandy, S. Shankar, and R.K. Srivastava Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells Mol Cancer 7 2008 60
9. R. Mikstacka, A.M. Rimando, and E. Ignatowicz Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro Plant Foods Hum Nutr 65 2010 57
10. S. Elmore Apoptosis: A review of programmed cell death Toxicol Pathol 35 2007 495
11. J.J. Li, L.W. Oberley, and D.K. St Clair Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase Oncogene 10 1995 1989
12. R.E. Oberley-Deegan, E.A. Regan, and V.L. Kinnula Extracellular superoxide dismutase and risk of COPD COPD 6 2009 307
13. C. Du, M. Fang, and Y. Li Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Cell 102 2000 33
14. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309
15. K.M. Bockbrader, M. Tan, and Y. Sun A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells Oncogene 24 2005 7381
16. G. Pani, R. Colavitti, and B. Bedogni Mitochondrial superoxide dismutase: A promising target for new anticancer therapies Curr Med Chem 11 2004 1299
17. V.L. Kinnula, U.A. Hodgson, and E.K. Lakari Extracellular superoxide dismutase has a highly specific localization in idiopathic pulmonary fibrosis/usual interstitial pneumonia Histopathology 49 2006 66
18. Y. Soini, M. Vakkala, and K. Kahlos MnSOD expression is less frequent in tumour cells of invasive breast carcinomas than in in situ carcinomas or non-neoplastic breast epithelial cells J Pathol 195 2001 156
19. M.J. Hitchler, K. Wikainapakul, and L. Yu Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells Epigenetics 1 2006 163
20. D. Boehning, R.L. Patterson, and L. Sedaghat Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis Nat Cell Biol 5 2003 1051
21. P. Guha, A. Dey, and M.V. Dhyani Calpain and caspase orchestrated death signal to accomplish apoptosis induced by resveratrol and its novel analog hydroxystilbene-1 [correction of hydroxstilbene-1] in cancer cells J Pharmacol Exp Ther 334 2010 381
22. M.P. Mattson, and S.L. Chan Calcium orchestrates apoptosis Nat Cell Biol 5 2003 1041
23. D. Sareen, S.R. Darjatmoko, and D.M. Albert Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer Mol Pharmacol 72 2007 1466
24. J.J. Li, L.W. Oberley, and M. Fan Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells FASEB J 12 1998 1713
25. R. Rizzuto, S. Marchi, and M. Bonora Ca(2+) transfer from the ER to mitochondria: When, how and why Biochim Biophys Acta 1787 2009 1342
26. R.I. Salganik The benefits and hazards of antioxidants: Controlling apoptosis and other protective mechanisms in cancer patients and the human population J Am Coll Nutr 20 Suppl 5 2001 464S discussion 473S