Morphine inhibits sleep-promoting neurons in the ventrolateral preoptic area via mu receptors and induces wakefulness in rats

Neuropsychopharmacology

Volumn 38, Issue 5, 2013, Pages 791-801

  Wang, Qin ^a   Yue, Xiao Fang ^a   Qu, Wei Min ^a   Tan, Rong ^a   Zheng, Ping ^a   Urade, Yoshihiro ^b   Huang, Zhi Li ^a  

^a FUDAN UNIVERSITY   (China)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

morphine; opioid receptor; VLPO; wakefulness

Indexed keywords

DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLORNITHYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; MORPHINE; MU OPIATE RECEPTOR; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ELECTROMYOGRAPHY; HYPERPOLARIZATION; ILLUMINATION; IN VITRO STUDY; MALE; MEMBRANE POTENTIAL; MICRODIALYSIS; NERVE CELL; NERVE CELL INHIBITION; NONHUMAN; NONREM SLEEP; PATCH CLAMP; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; REM SLEEP; SLEEP PROMOTING NEURON; SLEEP QUALITY; SLEEP WAKING CYCLE; VENTROLATERAL PREOPTIC AREA; WAKEFULNESS; WHOLE CELL;

ACTION POTENTIALS; ANALGESICS, OPIOID; ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; INJECTIONS, SUBCUTANEOUS; MALE; MICROINJECTIONS; MORPHINE; NEURONS; NOREPINEPHRINE; PATCH-CLAMP TECHNIQUES; PREOPTIC AREA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SLEEP; SODIUM CHANNEL BLOCKERS; SOMATOSTATIN; TETRODOTOXIN; WAKEFULNESS;

EID: 84875224948     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.244     Document Type: Article

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