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Volumn 31, Issue 5, 2013, Pages 724-730

MTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats

Author keywords

Akt mTOR signaling; fatty infiltration; PPAR ; rotator cuff tear; SREBP 1

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; FATTY ACID SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; RAPAMYCIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84875223268     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22254     Document Type: Article
Times cited : (60)

References (40)
  • 1
    • 84856899163 scopus 로고    scopus 로고
    • Role of fatty infiltration in the pathophysiology and outcomes of rotator cuff tears
    • Chaudhury S, Dines JS, Delos D, et al. 2012. Role of fatty infiltration in the pathophysiology and outcomes of rotator cuff tears. Arthritis Care Res (Hoboken) 64: 76-82.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , pp. 76-82
    • Chaudhury, S.1    Dines, J.S.2    Delos, D.3
  • 2
    • 0035147682 scopus 로고    scopus 로고
    • Surgical repair of chronic rotator cuff tears. A prospective long-term study
    • Cofield RH, Parvizi J, Hoffmeyer PJ, et al. 2001. Surgical repair of chronic rotator cuff tears. A prospective long-term study. J Bone Joint Surg Am 83-A: 71-77.
    • (2001) J Bone Joint Surg Am , vol.83 , pp. 71-77
    • Cofield, R.H.1    Parvizi, J.2    Hoffmeyer, P.J.3
  • 3
    • 4544366628 scopus 로고    scopus 로고
    • Effect of tendon release and delayed repair on the structure of the muscles of the rotator cuff: An experimental study in sheep
    • Gerber C, Meyer DC, Schneeberger AG, et al. 2004. Effect of tendon release and delayed repair on the structure of the muscles of the rotator cuff: an experimental study in sheep. J Bone Joint Surg Am 86-A: 1973-1982.
    • (2004) J Bone Joint Surg Am , vol.86 , pp. 1973-1982
    • Gerber, C.1    Meyer, D.C.2    Schneeberger, A.G.3
  • 4
    • 0028243496 scopus 로고
    • Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan
    • Goutallier D, Postel JM, Bernageau J, et al. 1994. Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan. Clin Orthop Relat Res 304: 78-83.
    • (1994) Clin Orthop Relat Res , vol.304 , pp. 78-83
    • Goutallier, D.1    Postel, J.M.2    Bernageau, J.3
  • 5
    • 0034876710 scopus 로고    scopus 로고
    • Arthroscopic rotator cuff repair: Transition from mini-open to all-arthroscopic
    • Yamaguchi K, Ball CM, Galatz LM,. 2001. Arthroscopic rotator cuff repair: transition from mini-open to all-arthroscopic. Clin Orthop Relat Res 390: 83-94.
    • (2001) Clin Orthop Relat Res , vol.390 , pp. 83-94
    • Yamaguchi, K.1    Ball, C.M.2    Galatz, L.M.3
  • 6
    • 63349103916 scopus 로고    scopus 로고
    • Adipogenic and myogenic gene expression in rotator cuff muscle of the sheep after tendon tear
    • Frey E, Regenfelder F, Sussmann P, et al. 2009. Adipogenic and myogenic gene expression in rotator cuff muscle of the sheep after tendon tear. J Orthop Res 27: 504-509.
    • (2009) J Orthop Res , vol.27 , pp. 504-509
    • Frey, E.1    Regenfelder, F.2    Sussmann, P.3
  • 7
    • 79955469939 scopus 로고    scopus 로고
    • Molecular mechanism of fatty degeneration in rotator cuff muscle with tendon rupture
    • Itoigawa Y, Kishimoto KN, Sano H, et al. 2011. Molecular mechanism of fatty degeneration in rotator cuff muscle with tendon rupture. J Orthop Res 29: 861-866.
    • (2011) J Orthop Res , vol.29 , pp. 861-866
    • Itoigawa, Y.1    Kishimoto, K.N.2    Sano, H.3
  • 8
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Fajas L, Schoonjans K, Gelman L, et al. 1999. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol 19: 5495-5503.
    • (1999) Mol Cell Biol , vol.19 , pp. 5495-5503
    • Fajas, L.1    Schoonjans, K.2    Gelman, L.3
  • 9
    • 50049116472 scopus 로고    scopus 로고
    • SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
    • Porstmann T, Santos CR, Griffiths B, et al. 2008. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8: 224-236.
    • (2008) Cell Metab , vol.8 , pp. 224-236
    • Porstmann, T.1    Santos, C.R.2    Griffiths, B.3
  • 10
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M, Sabatini DM,. 2009. An emerging role of mTOR in lipid biosynthesis. Curr Biol 19: R1046-R1052.
    • (2009) Curr Biol , vol.19
    • Laplante, M.1    Sabatini, D.M.2
  • 11
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM,. 2012. mTOR signaling in growth control and disease. Cell 149: 274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 12
    • 84863824874 scopus 로고    scopus 로고
    • Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model
    • Liu X, Joshi SK, Samagh SP, et al. 2012. Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model. J Orthop Res 30: 1440-1446.
    • (2012) J Orthop Res , vol.30 , pp. 1440-1446
    • Liu, X.1    Joshi, S.K.2    Samagh, S.P.3
  • 13
    • 84867855020 scopus 로고    scopus 로고
    • Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy
    • Gumucio JP, Davis ME, Bradley JR, et al. 2012. Rotator cuff tear reduces muscle fiber specific force production and induces macrophage accumulation and autophagy. J Orthop Res [Epub ahead of print].
    • (2012) J Orthop Res
    • Gumucio, J.P.1    Davis, M.E.2    Bradley, J.R.3
  • 15
    • 79951868621 scopus 로고    scopus 로고
    • A rat model of massive rotator cuff tears
    • Liu X, Manzano G, Kim HT, et al. 2011. A rat model of massive rotator cuff tears. J Orthop Res 29: 588-595.
    • (2011) J Orthop Res , vol.29 , pp. 588-595
    • Liu, X.1    Manzano, G.2    Kim, H.T.3
  • 16
    • 40949126161 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 expression and promoter/enhancer activity in skeletal muscle atrophy
    • Skittone LK, Liu X, Tseng A, et al. 2008. Matrix metalloproteinase-2 expression and promoter/enhancer activity in skeletal muscle atrophy. J Orthop Res 26: 357-363.
    • (2008) J Orthop Res , vol.26 , pp. 357-363
    • Skittone, L.K.1    Liu, X.2    Tseng, A.3
  • 17
    • 0035736260 scopus 로고    scopus 로고
    • Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    • Bodine SC, Stitt TN, Gonzalez M, et al. 2001. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3: 1014-1019.
    • (2001) Nat Cell Biol , vol.3 , pp. 1014-1019
    • Bodine, S.C.1    Stitt, T.N.2    Gonzalez, M.3
  • 18
    • 33846885682 scopus 로고    scopus 로고
    • Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol
    • Kline WO, Panaro FJ, Yang H, et al. 2007. Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol. J Appl Physiol 102: 740-747.
    • (2007) J Appl Physiol , vol.102 , pp. 740-747
    • Kline, W.O.1    Panaro, F.J.2    Yang, H.3
  • 19
    • 0034940413 scopus 로고    scopus 로고
    • Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids
    • Koopman R, Schaart G, Hesselink MK,. 2001. Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids. Histochem Cell Biol 116: 63-68.
    • (2001) Histochem Cell Biol , vol.116 , pp. 63-68
    • Koopman, R.1    Schaart, G.2    Hesselink, M.K.3
  • 20
    • 84862638075 scopus 로고    scopus 로고
    • The effect of tear size and nerve injury on rotator cuff muscle fatty degeneration in a rodent animal model
    • Kim HM, Galatz LM, Lim C, et al. 2011. The effect of tear size and nerve injury on rotator cuff muscle fatty degeneration in a rodent animal model. J Shoulder Elbow Surg 21: 847-858.
    • (2011) J Shoulder Elbow Surg , vol.21 , pp. 847-858
    • Kim, H.M.1    Galatz, L.M.2    Lim, C.3
  • 21
    • 34447265750 scopus 로고    scopus 로고
    • Fatty infiltration of the torn rotator cuff worsens over time in a rabbit model
    • Rubino LJ, Stills HF Jr, Sprott DC, et al. 2007. Fatty infiltration of the torn rotator cuff worsens over time in a rabbit model. Arthroscopy 23: 717-722.
    • (2007) Arthroscopy , vol.23 , pp. 717-722
    • Rubino, L.J.1    Stills, Jr.H.F.2    Sprott, D.C.3
  • 22
    • 28544441373 scopus 로고    scopus 로고
    • Changes in rotator cuff muscle volume, fat content, and passive mechanics after chronic detachment in a canine model
    • Safran O, Derwin KA, Powell K, et al. 2005. Changes in rotator cuff muscle volume, fat content, and passive mechanics after chronic detachment in a canine model. J Bone Joint Surg Am 87: 2662-2670.
    • (2005) J Bone Joint Surg Am , vol.87 , pp. 2662-2670
    • Safran, O.1    Derwin, K.A.2    Powell, K.3
  • 23
    • 33745736142 scopus 로고    scopus 로고
    • The association of suprascapular neuropathy with massive rotator cuff tears: A preliminary report
    • Mallon WJ, Wilson RJ, Basamania CJ,. 2006. The association of suprascapular neuropathy with massive rotator cuff tears: a preliminary report. J Shoulder Elbow Surg 15: 395-398.
    • (2006) J Shoulder Elbow Surg , vol.15 , pp. 395-398
    • Mallon, W.J.1    Wilson, R.J.2    Basamania, C.J.3
  • 24
    • 35648954003 scopus 로고    scopus 로고
    • Reversal of suprascapular neuropathy following arthroscopic repair of massive supraspinatus and infraspinatus rotator cuff tears
    • Costouros JG, Porramatikul M, Lie DT, et al. 2007. Reversal of suprascapular neuropathy following arthroscopic repair of massive supraspinatus and infraspinatus rotator cuff tears. Arthroscopy 23: 1152-1161.
    • (2007) Arthroscopy , vol.23 , pp. 1152-1161
    • Costouros, J.G.1    Porramatikul, M.2    Lie, D.T.3
  • 25
    • 77957891295 scopus 로고    scopus 로고
    • Development of fatty atrophy after neurologic and rotator cuff injuries in an animal model of rotator cuff pathology
    • Rowshan K, Hadley S, Pham K, et al. 2010. Development of fatty atrophy after neurologic and rotator cuff injuries in an animal model of rotator cuff pathology. J Bone Joint Surg Am 92: 2270-2278.
    • (2010) J Bone Joint Surg Am , vol.92 , pp. 2270-2278
    • Rowshan, K.1    Hadley, S.2    Pham, K.3
  • 26
    • 80051472584 scopus 로고    scopus 로고
    • Suprascapular neuropathy in a shoulder referral practice
    • Boykin RE, Friedman DJ, Zimmer ZR, et al. 2011. Suprascapular neuropathy in a shoulder referral practice. J Shoulder Elbow Surg 20: 983-988.
    • (2011) J Shoulder Elbow Surg , vol.20 , pp. 983-988
    • Boykin, R.E.1    Friedman, D.J.2    Zimmer, Z.R.3
  • 27
    • 0141927450 scopus 로고    scopus 로고
    • An anatomic study of the effects on the suprascapular nerve due to retraction of the supraspinatus muscle after a rotator cuff tear
    • Albritton MJ, Graham RD, Richards RS II, et al. 2003. An anatomic study of the effects on the suprascapular nerve due to retraction of the supraspinatus muscle after a rotator cuff tear. J Shoulder Elbow Surg 12: 497-500.
    • (2003) J Shoulder Elbow Surg , vol.12 , pp. 497-500
    • Albritton, M.J.1    Graham, R.D.2    Richards, I.I.R.S.3
  • 28
    • 84861872697 scopus 로고    scopus 로고
    • Adipogenesis: From stem cell to adipocyte
    • Tang QQ, Lane MD,. 2012. Adipogenesis: from stem cell to adipocyte. Annu Rev Biochem 81: 715-736.
    • (2012) Annu Rev Biochem , vol.81 , pp. 715-736
    • Tang, Q.Q.1    Lane, M.D.2
  • 29
    • 84857461922 scopus 로고    scopus 로고
    • Regulation of adipocyte formation by GLP-1/GLP-1R signaling
    • Challa TD, Beaton N, Arnold M, et al. 2012. Regulation of adipocyte formation by GLP-1/GLP-1R signaling. J Biol Chem 287: 6421-6430.
    • (2012) J Biol Chem , vol.287 , pp. 6421-6430
    • Challa, T.D.1    Beaton, N.2    Arnold, M.3
  • 30
    • 21344460965 scopus 로고    scopus 로고
    • TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation
    • Jakkaraju S, Zhe X, Pan D, et al. 2005. TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation. Dev Cell 9: 39-49.
    • (2005) Dev Cell , vol.9 , pp. 39-49
    • Jakkaraju, S.1    Zhe, X.2    Pan, D.3
  • 31
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment
    • McBeath R, Pirone DM, Nelson CM, et al. 2004. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6: 483-495.
    • (2004) Dev Cell , vol.6 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3
  • 32
    • 0032516081 scopus 로고    scopus 로고
    • ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
    • Kim JB, Wright HM, Wright M, et al. 1998. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 95: 4333-4337.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3
  • 33
    • 84859405092 scopus 로고    scopus 로고
    • Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
    • Jeon BN, Kim YS, Choi WI, et al. 2012. Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. J Lipid Res 53: 755-766.
    • (2012) J Lipid Res , vol.53 , pp. 755-766
    • Jeon, B.N.1    Kim, Y.S.2    Choi, W.I.3
  • 34
    • 7044234995 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis
    • Kim JE, Chen J,. 2004. regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis. Diabetes 53: 2748-2756.
    • (2004) Diabetes , vol.53 , pp. 2748-2756
    • Kim, J.E.1    Chen, J.2
  • 35
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • Houde VP, Brule S, Festuccia WT, et al. 2010. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 59: 1338-1348.
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3
  • 36
    • 84861422827 scopus 로고    scopus 로고
    • Major involvement of mTOR in the PPARgamma-induced stimulation of adipose tissue lipid uptake and fat accretion
    • Blanchard PG, Festuccia WT, Houde VP, et al. 2012. Major involvement of mTOR in the PPARgamma-induced stimulation of adipose tissue lipid uptake and fat accretion. J Lipid Res 53: 1117-1125.
    • (2012) J Lipid Res , vol.53 , pp. 1117-1125
    • Blanchard, P.G.1    Festuccia, W.T.2    Houde, V.P.3
  • 37
    • 79961165137 scopus 로고    scopus 로고
    • MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
    • Peterson TR, Sengupta SS, Harris TE, et al. 2011. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146: 408-420.
    • (2011) Cell , vol.146 , pp. 408-420
    • Peterson, T.R.1    Sengupta, S.S.2    Harris, T.E.3
  • 38
    • 84861043736 scopus 로고    scopus 로고
    • Connecting mTORC1 signaling to SREBP-1 activation
    • Bakan I, Laplante M,. 2012. Connecting mTORC1 signaling to SREBP-1 activation. Curr Opin Lipidol 23: 226-234.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 226-234
    • Bakan, I.1    Laplante, M.2
  • 39
    • 1842419374 scopus 로고    scopus 로고
    • Supraspinatus tendon organizational and mechanical properties in a chronic rotator cuff tear animal model
    • Gimbel JA, Van Kleunen JP, Mehta S, et al. 2004. Supraspinatus tendon organizational and mechanical properties in a chronic rotator cuff tear animal model. J Biomech 37: 739-749.
    • (2004) J Biomech , vol.37 , pp. 739-749
    • Gimbel, J.A.1    Van Kleunen, J.P.2    Mehta, S.3
  • 40
    • 34548842483 scopus 로고    scopus 로고
    • Contributions of the different rabbit models to our understanding of rotator cuff pathology
    • Gupta R, Lee TQ,. 2007. Contributions of the different rabbit models to our understanding of rotator cuff pathology. J Shoulder Elbow Surg 16: S149-S157.
    • (2007) J Shoulder Elbow Surg , vol.16
    • Gupta, R.1    Lee, T.Q.2


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