Chronic hepatitis B virus (HBV) infection in children: 25 years' experience

Journal of Viral Hepatitis

Volumn 20, Issue 4, 2013, Pages

  Popalis, C ^a,b   Yeung, L T F ^a,b,c,d   Ling, S C ^a,b   Ng, V ^a,b   Roberts, E A ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c Rouge Valley Health System   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

ethnic group; HBeAg seroconversion; hepatocellular carcinoma; inactive carrier; interferon

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN;

ADULT; ADULTHOOD; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANOREXIA; ARTICLE; ASIAN; BETA THALASSEMIA; CHILD; CHILDHOOD DISEASE; DIARRHEA; ETHNICITY; EYE JAUNDICE; FATIGUE; FEMALE; FOLLOW UP; HEPATITIS B; HUMAN; LIVER BIOPSY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MOTHER; NAUSEA; NONALCOHOLIC FATTY LIVER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SENSITIVITY ANALYSIS; SEROCONVERSION; SURVIVAL; VIRUS LOAD; VIRUS TRANSMISSION;

ADOLESCENT; AGE FACTORS; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; CHILD; DNA, VIRAL; ETHNIC GROUPS; FEMALE; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; MALE; TREATMENT OUTCOME;

EID: 84875218851     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12019     Document Type: Article

References (27)

1. Lavanchy D,. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11 (2): 97-107.
2. Perz JF, Armstrong GL, Farrington LA, Hutin YJ, Bell BP,. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 2006; 45 (4): 529-538.
3. Haber BA, Block JM, Jonas MM, et al,. Recommendations for screening, monitoring, and referral of pediatric chronic hepatitis B. Pediatrics 2009; 124 (5): e1007-e1013.
4. Lok AS,. Navigating the maze of hepatitis B treatments. Gastroenterology 2007; 132 (4): 1586-1594.
5. Chen CJ, Yang HI, Su J, et al,. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295 (1): 65-73.
6. Iloeje UH, Yang HI, Su J, et al,. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130 (3): 678-686.
7. Ni YH, Chang MH, Chen PJ, et al,. Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. Gastroenterology 2007; 132 (7): 2340-2345.
8. Visible Minority Population and Population Group Reference Guide, 2006 Census. 2006 2011-04-05 [cited 2012 Feb. 5]; Details the Statistics Canada 2006 Census Form 2B questionnaire regarding visible minority population.]. Available from: http://www12.statcan.ca/census-recensement/2006/ref/rp-guides/visible- minority-minorites-visibles-eng.cfm
9. Sokal EM, Conjeevaram HS, Roberts EA, et al,. Interferon alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial. Gastroenterology 1998; 114 (5): 988-995.
10. Marx G, Martin SR, Chicoine JF, Alvarez F,. Long-term follow-up of chronic hepatitis B virus infection in children of different ethnic origins. J Infect Dis 2002; 186 (3): 295-301.
11. Lok AS, Lai CL,. A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. Hepatology 1988; 8 (5): 1130-1133.
12. Bortolotti F, Guido M, Bartolacci S, et al,. Chronic hepatitis B in children after e antigen seroclearance: final report of a 29-year longitudinal study. Hepatology 2006; 43 (3): 556-562.
13. Evans AA, Fine M, London WT,. Spontaneous seroconversion in hepatitis B e antigen-positive chronic hepatitis B: implications for interferon therapy. J Infect Dis 1997; 176 (4): 845-850.
14. Wu JF, Tsai WY, Hsu HY, et al,. Effect of puberty onset on spontaneous hepatitis B virus e antigen seroconversion in men. Gastroenterology 2010; 138 (3): 942-948.
15. Mozer-Lisewska I, Mania A, Sluzewski W, et al,. Factors influencing clinical course and histological findings in children with chronic hepatitis B. Eur J Gastroenterol Hepatol 2009; 21 (12): 1400-1406.
16. Zacharakis G, Koskinas J, Kotsiou S, et al,. Natural history of chronic hepatitis B virus infection in children of different ethnic origins: a cohort study with up to 12 years' follow-up in northern Greece. J Pediatr Gastroenterol Nutr 2007; 44 (1): 84-91.
17. Livingston SE, Simonetti JP, Bulkow LR, et al,. Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and F. Gastroenterology 2007; 133 (5): 1452-1457.
18. Yeung LT, Roberts EA,. Current issues in the management of paediatric viral hepatitis. Liver Int 2010; 30 (1): 5-18.
19. Yuen MF, Hui CK, Cheng CC, Wu CH, Lai YP, Lai CL,. Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: the effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications. Hepatology 2001; 34 (1): 139-145.
20. Bortolotti F, Jara P, Barbera C, et al,. Long term effect of alpha interferon in children with chronic hepatitis B. Gut 2000; 46 (5): 715-718.
21. Hsu HY, Tsai HY, Wu TC, et al,. Interferon-alpha treatment in children and young adults with chronic hepatitis B: a long-term follow-up study in Taiwan. Liver Int 2008; 28 (9): 1288-1297.
22. Bortolotti F, Wirth S, Crivellaro C, Alberti A, Martine U, de Moliner L,. Long-term persistence of hepatitis B virus DNA in the serum of children with chronic hepatitis B after hepatitis B e antigen to antibody seroconversion. J Pediatr Gastroenterol Nutr 1996; 22 (3): 270-274.
23. Bortolotti F, Jara P, Crivellaro C, et al,. Outcome of chronic hepatitis B in Caucasian children during a 20-year observation period. J Hepatol 1998; 29 (2): 184-190.
24. Ruiz-Moreno M, Otero M, Millan A, et al,. Clinical and histological outcome after hepatitis B e antigen to antibody seroconversion in children with chronic hepatitis B. Hepatology 1999; 29 (2): 572-575.
25. Brunetto MR, Oliveri F, Colombatto P, et al,. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology 2010; 139 (2): 483-490.
26. Chen YC, Huang SF, Chu CM, Liaw YF,. Serial HBV DNA levels in patients with persistently normal transaminase over 10 years following spontaneous HBeAg seroconversion. J Viral Hepat 2012; 19 (2): 138-146.
27. Kang HS, Kang KS, Song BC,. Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children. J Korean Med Sci 2011; 26 (4): 546-550.