Interferon-α treatment in children and young adults with chronic hepatitis B: A long-term follow-up study in Taiwan

Liver International

Volumn 28, Issue 9, 2008, Pages 1288-1297

  Hsu, Hong Yuan ^a,b   Tsai, Hsiu Yuan ^a   Wu, Tzee Chung ^c   Chiang, Cheng Lun ^a,b   Ni, Yen Hsuan ^a   Chen, Pei Jer ^b   Chang, Mei Hwei ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Children; Chronic hepatitis B; Interferon therapy; Young adults

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; PREDNISOLONE; RECOMBINANT ALPHA2B INTERFERON; VIRUS DNA;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LONG TERM CARE; MALE; MONOTHERAPY; MUTANT; NONHUMAN; PERINATAL INFECTION; PROGNOSIS; SEROCONVERSION; SHORT COURSE THERAPY; STOP CODON; TAIWAN; TREATMENT DURATION; VIRUS DETECTION; VIRUS MUTANT; VIRUS TYPING;

EID: 84983724527     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01746.x     Document Type: Article

References (25)

1. Stevens CE, Beasley RP, Tsui J, Lee WC. Vertical transmission of hepatitis antigen in Taiwan. N Engl J Med 1975; 292: 771-4.
2. Hsu HY, Chang MH, Chen DS, Lee CY, Sung JL. Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: A study just before mass hepatitis vaccination program in Taiwan. J Med Virol 1986; 18: 301-7.
3. Chang MH, Hwang LY, Hsu HC, Lee CY, Beasley RP. Prospective study of asymptomatic HBsAg carrier children infected in the perinatal period: clinical and liver histologic studies. Hepatology 1988; 8: 374-7.
4. Bortolotti F, Calzia R, Cadrobbi P, et al. Liver cirrhosis associated with chronic hepatitis B virus infection in childhood. J Pediatr 1986; 108: 224-7.
5. Chang MH, Chen DS, Hsu HC, Hsu HY, Lee CY. Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma. Cancer 1989; 64: 2377-80.
6. Chu CM, Karayiannis P, Fowler MJ, Monjardino J, Liaw YF, Thomas HC. Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum. Hepatology 1985; 5: 431-4.
7. Ruiz Moreno M, Rua MJ, Molina J, et al. Prospective, randomized, controlled trial of IFN alpha in children with chronic hepatitis B. Hepatology 1991; 13: 1035-9.
8. Barbera C, Bortolotti F, Crivellaro C, et al. Recombinant interferon-alpha 2a hastens the rate of HBeAg clearance in children with chronic hepatitis B. Hepatology 1994; 20: 287-90.
9. Sokal EM, Conjeevaram H, Roberts E, et al. Interferon alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial. Gastroenterology 1998; 114: 988-95.
10. Lai CL, Lok A, Lin HJ, et al. Placebo controlled trial of recombinant alpha 2 interferon in Chinese HBsAg-carrier children. Lancet 1987; 2: 877-80.
11. Lai CL, Lin H J, Lau JYN, et al. Effect of recombinant alpha 2 interferon with or without prednisolone in Chinese HBsAg carrier children. Q J Med 1991; 78: 155-63.
12. Yeh SH, Tsai CY, Kao JH, et al. Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis. J Hepatol 2004; 41: 659-66.
13. Ni YH, Chang MH, Wang KJ, et al. Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma. Gastroenterology 2004; 127: 1733-8.
14. Chang MH, Hsu HY, Ni YH, et al. Precore stop codon mutant in chronic hepatitis B virus infection in children: Its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen. J Hepatol 1998; 28: 915-22.
15. Bortolotti F, Jara P, Barbera C, et al. Long term effect of alfa interferon in children with chronic hepatitis B. Gut 2000; 46: 715-8.
16. Boxall EH, Sira J, Ballard AL, Davies P, Kelly DA. Long-term follow-up of hepatitis B carrier children treated with interferon and prednisolone. J Med Virol 2006; 78: 888-95.
17. Ruiz-Moreno M, Camps T, Jimenez J, et al. Factors predictive of response to interferon therapy in children with chronic hepatitis B. J Hepatol 1995; 22: 540-4.
18. Torre D, Tambini R. Interferon alpha therapy for chronic hepatitis B in children: A metaanalysis. Clin Infect Dis 1996; 23: 131-7.
19. Jonas MM. Treatment of chronic hepatitis B in children. J Pediatr Gastro Nutr 2006; 43: S56-60.
20. Kobak GE, MacKenzie T, Sokol RJ, Narkewicz MR. Interferon treatment for chronic hepatitis B: Enhanced response in children 5 years or younger. J Pediatr 2004; 145: 340-5.
21. Lin SM, Sheen IS, Chien RN, Chu CM, Liaw YF. Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. Hepatology 1999; 29: 971-5.
22. Ruiz-Moreno M, Jimenez J, Porres JC, Bartolome J, Moreno A, Carreno V. A controlled trial of recombinant interferon-alpha in Caucasian children with chronic hepatitis B. Digestion 1990; 45: 26-33.
23. Barbera C, Bortolotti F, Crivellaro C, et al. Recombinant interferon-α 2a hastens the rate of HBeAg clearance in children with chronic hepatitis B. Hepatology 1994; 20: 287-90.
24. Diem HVT, Bourgois A, Bontems P, et al. Chronic hepatitis B infection: long term comparison of children receiving interferon alpha and untreated controls. J Pediatr Gastro Nutr 2005; 40: 141-5.
25. D'Antiga L, Aw M, Atkins M, Moorat A, Vergani D, Mieli-Vergani G. Combined lamivudine/interferon-alpha treatment in immunotolerant children perinatally infected with hepatitis B: A pilot study. J Pediatr 2006; 148: 228-3.