Spontaneous seroconversion in hepatitis B e antigen - Positive chronic hepatitis B: Implications for interferon therapy

Journal of Infectious Diseases

Volumn 176, Issue 4, 1997, Pages 845-850

  Evans, Alison A ^a   Fine, Manette ^a   London, W Thomas ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; HEPATITIS B ANTIGEN;

ADOLESCENT; ADULT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CHILD; CHRONIC HEPATITIS; DECISION MAKING; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; PATIENT CARE; POPULATION RESEARCH; PRIORITY JOURNAL; SEROCONVERSION; VIRUS CARRIER;

EID: 0030861638     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/516538     Document Type: Article

References (27)

1. Hoofnagle J, Shafritz D, Popper H. Chronic type B hepatitis and the "healthy" HBsAg carrier state. Hepatology 1987;7:758-63.
2. Fattovich G, Rugge M, Brollo L, et al. Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. Hepatology 1986;6:167-72.
3. Alward WLM, McMahon BJ, Hall DB, Heyward WL, Francis DP, Bender TR. The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma. J Infect Dis 1985;151:604-9.
4. Dragosics B, Ferenci P, Hitchman E, Denk H. Long-term follow-up study of asymptomatic HBsAg-positive voluntary blood donors in Austria: a clinical and histologic evaluation of 242 cases. Hepatology 1987;7:302-6.
5. Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med 1993;119:312-23.
6. Perrillo RP. Interferon in the management of chronic hepatitis B. Dig Dis Sci 1993;38:577-93.
7. Hoofnagle JH, Di Bisceglie AM. The treatment of chronic viral hepatitis. N Engl J Med 1997;336:347-56.
8. Brook MG, Karayiannis P, Thomas HC. Which patients with chronic hepatitis B virus infection will respond to α-interferon therapy? A statistical analysis of predictive factors. Hepatology 1989;10:761-3.
9. London W, Atleson J, Eto T, Fine M, Hwang C. Early detection of hepatocellular carcinoma among Asians living in the United States. In: Tabor E, Di Bisceglie A, Purcell R, eds. Etiology, pathology, and treatment of hepatocellular carcinoma in North America. Houston: Portfolio Publishing, 1991:243-53.
10. Cnaan A, Ryan L. Survival analysis in natural history studies of disease. Stat Med 1989;8:1255-68.
11. Breslow N, Day N. Statistical methods in cancer research. In: Heseltine E, ed. The design and analysis of cohort studies. Vol. 2. Lyon, France: International Agency of Research on Cancer, 1987; IARC scientific publications no. 82.
12. Ruiz-Moreno M, Rua MJ, Molina J, et al. Prospective, randomized controlled trial of interferon-alpha in children with chronic hepatitis B. Hepatology 1991;13:1035-9.
13. Lai CL, Lin HJ, Lau JN, et al. Effect of recombinant alpha 2 interferon with or without prednisone in Chinese HBsAg carrier children. Quart J Med 1991;78:155-63.
14. Utili R, Sagnelli E, Galanti B, et al. Prolonged treatment of children with chronic hepatitis B with recombinant alpha 2a-interferon: a controlled, randomized study. Am J Gastroenterol 1991;86:327-30.
15. Lai C, Lok A, Lin H, Wu P, Yeoh E, Yeung C. Placebo-controlled trial of recombinant α -interferon in Chinese HBsAg-carrier children. Lancet 1987;2:877-80.
16. Korenman J, Baker B, Waggoner J, Everhart JE, Di Bisceglie AM, Hoofnagle JH. Long-term remission of chronic hepatitis B after alpha-interferon therapy. Ann Intern Med 1991;114:629-34.
17. Niederau C, Heintges T, Lange S, et al. Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. N Engl J Med 1996;334:1422-7.
18. Lok A, Lai C, Wu P, Leung E, Lam T. Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection. Gastroenterology 1987;92:1839-43.
19. Renault PF, Hoofnagle JH, Park Y, et al. Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med 1987;147:1577-80.
20. Giacchino R, Timitilli A, Cristina E, et al. Repeated course of interferon treatment in chronic hepatitis B in childhood. Arch Virol 1992;(suppl)4:273-6.
21. Janssen HL, Schalm SW, Berk L, de Man RA, Heiijtink RA. Repeated courses of alpha-interferon for treatment of chronic hepatitis type B. J Hepatol 1993;17:547-51.
22. Bortolotti F, Cadrobbi P, Crivellaro C, et al. Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterology 1990;99:805-10.
23. Liaw YF, Chu CM, Su IJ, Huang MJ, Lin DY, Chang-Chien CS. Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology 1983;84:216-9.
24. Lok AS, Wu PC, Lai CL, et al. A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology 1992;102:2091-7.
25. Moyes CD, Milne A, Waldon J Liver function of hepatitis B carriers in childhood. Pediatr Infect Dis J 1993;12:120-5.
26. Immunization Practices Advisory Committee. Protection against viral hepatitis. Recommendations of the Immunization Practices Advisory Committee. MMWR 1990;39:1-26.
27. Rothman KJ. Modern epidemiology. Boston: Little, Brown, 1986.