Association of a functional polymorphism in the promoter region of TLR-3 with osteoarthritis: A two-stage case-control study

Journal of Orthopaedic Research

Volumn 31, Issue 5, 2013, Pages 680-685

  Yang, Hsin Yi ^a   Lee, Herng Sheng ^b   Lee, Chian Her ^c   Fang, Wen Hui ^b   Chen, Hsiang Cheng ^b   Salter, Donald M ^d   Su, Sui Lung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

functional polymorphism; osteoarthritis; toll like receptor

Indexed keywords

DEXAMETHASONE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

AGED; ARTICLE; CARTILAGE CELL; CHINESE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CARTILAGE; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RISK FACTORS; TOLL-LIKE RECEPTOR 3;

EID: 84875213362     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22291     Document Type: Article

References (32)

1. Valdes AM, Spector TD,. 2009. The contribution of genes to osteoarthritis. Med Clin N Am 93: 45-66.
2. Zhang Y, Jordan JM,. 2010. Epidemiology of osteoarthritis. Clin Geriatr Med 26: 355-369.
3. Scanzello CR, Plaas A, Crow MK,. 2008. Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol 20: 565-572.
4. Kawai T, Akira S,. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
5. Kim HA, Cho ML, Choi HY, et al. 2006. The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes. Arthritis Rheum 54: 2152-2163.
6. Zhang Q, Hui W, Litherland GJ, et al. 2008. Differential Toll-like receptor-dependent collagenase expression in chondrocytes. Ann Rheum Dis 67: 1633-1641.
7. Schwartz DA, Cook DN,. 2005. Polymorphisms of the Toll-like receptors and human disease. Clin infect dis 41: S403-S407.
8. Lee YH, Lee HS, Choi SJ, et al. 2012. Associations between TLR polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis. Clin Exp Rheumatol 30: 262-265.
9. Misch EA, Hawn TR,. 2008. Toll-like receptor polymorphisms and susceptibility to human disease. Clin Sci (Lond) 114: 347-360.
10. Coenen MJ, Enevold C, Barrera P, et al. 2010. Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome. PloS ONE 5: e14326.
11. Enevold C, Radstake TR, Coenen MJ, et al. 2010. Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis. J Rheumatol 37: 905-910.
12. Su SL, Yang HY, Lee CH, et al. 2012. The (-1486T/C) promoter polymorphism of the TLR-9 gene is associated with end-stage knee osteoarthritis in a Chinese population. J Orthop Res 30: 9-14.
13. Cheng PL, Eng HL, Chou MH, et al. 2007. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. Transl Res 150: 311-318.
14. Noguchi E, Nishimura F, Fukai H, et al. 2004. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy 34: 177-183.
15. Zhu W, Meng L, Jiang C, et al. 2011. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther 13: R103.
16. Barrett JC, Fry B, Maller J, et al. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
17. Chapman K, Valdes AM,. 2012. Genetic factors in OA pathogenesis. Bone 51: 258-264.
18. arcOGEN Consortium, arcOGEN Collaborators. 2012. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380: 815-823.
19. Kerkhof HJ, Lories RJ, Meulenbelt I, et al. 2010. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum 62: 499-510.
20. Miyamoto Y, Shi D, Nakajima M, et al. 2008. Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nat Genet 40: 994-998.
21. Meulenbelt I, Chapman K, Dieguez-Gonzalez R, et al. 2009. Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations. Hum Mol Genet 18: 1518-1523.
22. Liu-Bryan R, Terkeltaub R,. 2010. Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice. Arthritis Rheum 62: 2004-2012.
23. Hinds DA, Stokowski RP, Patil N, et al. 2004. Matching strategies for genetic association studies in structured populations. Am J Hum Genet 74: 317-325.
24. Etem EO, Elyas H, Ozgocmen S, et al. 2011. The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients. Rheumatol Int 31: 1369-1374.
25. Kim KW, Cho ML, Lee SH, et al. 2007. Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation. Immunol Lett 110: 54-64.
26. Bobacz K, Sunk IG, Hofstaetter JG, et al. 2007. Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheum 56: 1880-1893.
27. Gast A, Bermejo JL, Claus R, et al. 2011. Association of inherited variation in Toll-like receptor genes with malignant melanoma susceptibility and survival. PloS ONE 6: e24370.
28. Loughlin J,. 2002. Genome studies and linkage in primary osteoarthritis. Rheum Dis Clin North Am 28: 95-109.
29. Shen N, Fu Q, Deng Y, et al. 2010. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci USA 107: 15838-15843.
30. Heinz S, Haehnel V, Karaghiosoff M, et al. 2003. Species-specific regulation of Toll-like receptor 3 genes in men and mice. J Biol Chem 278: 21502-21509.
31. Jones LA, Kreem S, Shweash M, et al. 2010. Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone. J Immunol 185: 4525-4534.
32. Hermoso MA, Matsuguchi T, Smoak K, et al. 2004. Glucocorticoids and tumor necrosis factor alpha cooperatively regulate Toll-like receptor 2 gene expression. Mol Cell Biol 24: 4743-4765.