메뉴 건너뛰기




Volumn 24, Issue 3, 2012, Pages 272-277

The evolving paradigm of second-line hormonal therapy options for castration-resistant prostate cancer

Author keywords

abiraterone acetate; ARN 509; castrate resistant prostate cancer; MDV3100; second line hormonal therapy; TAK 700; TOK 001

Indexed keywords

4 [3 [4 CYANO 3 (TRIFLUOROMETHYL)PHENYL] 5,5 DIMETHYL 4 OXO 2 THIOXO 1 IMIDAZOLIDINYL] 2 FLUORO N METHYLBENZAMIDE; ABIRATERONE ACETATE; AMINOGLUTETHIMIDE; ANDROGEN; ANTINEOPLASTIC AGENT; ARN 509; BICALUTAMIDE; DOCETAXEL; GALETERONE; GONADORELIN; KETOCONAZOLE; ORTERONEL; PLACEBO; PREDNISONE; PROSTATE SPECIFIC ANTIGEN; UNCLASSIFIED DRUG;

EID: 84859815355     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328351059d     Document Type: Review
Times cited : (23)

References (37)
  • 1
    • 84928580276 scopus 로고
    • Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1941; 1:293-297.
    • (1941) Cancer Res , vol.1 , pp. 293-297
    • Huggins, C.1    Hodges, C.V.2
  • 2
    • 0001189211 scopus 로고
    • Studies on prostatic cancer: II the effects of castration on advanced carcinoma of the prostate gland
    • Huggins C, Stevens RE Jr, Hodges CV. Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 1941; 43:209-223.
    • (1941) Arch Surg , vol.43 , pp. 209-223
    • Huggins, C.1    Stevens Jr., R.E.2    Hodges, C.V.3
  • 3
    • 77951523950 scopus 로고    scopus 로고
    • Phase i clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castrationresistant prostate cancer who received prior ketoconazole therapy
    • Ryan CJ, Smith MR, Fong L, et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castrationresistant prostate cancer who received prior ketoconazole therapy. J Clin Oncol 2010; 28:1481-1488.
    • (2010) J Clin Oncol , vol.28 , pp. 1481-1488
    • Ryan, C.J.1    Smith, M.R.2    Fong, L.3
  • 5
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • Montgomery RB, Mostaghel EA, Vessella R, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008; 68:4447-4454.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3
  • 6
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke JA, Guns ES, Lubik AA, et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008; 68:6407-6415.
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3
  • 8
    • 76149137405 scopus 로고    scopus 로고
    • Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    • Leon CG, Locke JA, Adomat HH, et al. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate 2010; 70:390-400.
    • (2010) Prostate , vol.70 , pp. 390-400
    • Leon, C.G.1    Locke, J.A.2    Adomat, H.H.3
  • 10
    • 79957532351 scopus 로고    scopus 로고
    • Evolving therapeutic paradigms for advanced prostate cancer
    • 8
    • Ruch JM, Hussain MH. Evolving therapeutic paradigms for advanced prostate cancer. Oncology (Williston Park) 2011; 25:496-504; 8.
    • (2011) Oncology (Williston Park) , vol.25 , pp. 496-504
    • Ruch, J.M.1    Hussain, M.H.2
  • 11
    • 80053071543 scopus 로고    scopus 로고
    • Androgen receptor rediscovered: The new biology and targeting the androgen receptor therapeutically
    • Ryan CJ, Tindall DJ. Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically. J Clin Oncol 2011; 29:3651-3658.
    • (2011) J Clin Oncol , vol.29 , pp. 3651-3658
    • Ryan, C.J.1    Tindall, D.J.2
  • 12
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun S, Sprenger CC, Vessella RL, et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 2010; 120:2715-2730.
    • (2010) J Clin Invest , vol.120 , pp. 2715-2730
    • Sun, S.1    Sprenger, C.C.2    Vessella, R.L.3
  • 13
    • 0029011116 scopus 로고
    • Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
    • Taplin ME, Bubley GJ, Shuster TD, et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 1995; 332:1393-1398.
    • (1995) N Engl J Med , vol.332 , pp. 1393-1398
    • Taplin, M.E.1    Bubley, G.J.2    Shuster, T.D.3
  • 15
    • 79959294088 scopus 로고    scopus 로고
    • SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer
    • Yang M, Xie W, Mostaghel E, et al. SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 2011; 29:2565-2573.
    • (2011) J Clin Oncol , vol.29 , pp. 2565-2573
    • Yang, M.1    Xie, W.2    Mostaghel, E.3
  • 16
    • 0006791684 scopus 로고
    • Effect of bilateral adrenalectomy on certain human tumors
    • Huggins C, Bergenstal DM. Effect of bilateral adrenalectomy on certain human tumors. Proc Natl Acad Sci USA 1952; 38:73-76.
    • (1952) Proc Natl Acad Sci USA , vol.38 , pp. 73-76
    • Huggins, C.1    Bergenstal, D.M.2
  • 17
    • 80053940699 scopus 로고    scopus 로고
    • Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
    • Cai C, Balk SP. Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy. Endocr Relat Cancer 2011; 18:R175-R182.
    • (2011) Endocr Relat Cancer , vol.18
    • Cai, C.1    Balk, S.P.2
  • 18
    • 8344219790 scopus 로고    scopus 로고
    • Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy
    • DOI 10.1097/00001813-200410000-00004
    • Kruit WH, Stoter G, Klijn JG. Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy. Anticancer Drugs 2004; 15:843-847. (Pubitemid 39482924)
    • (2004) Anti-Cancer Drugs , vol.15 , Issue.9 , pp. 843-847
    • Kruit, W.H.J.1    Stoter, G.2    Klijn, J.G.M.3
  • 19
    • 0020531983 scopus 로고
    • Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes
    • Loose DS, Kan PB, Hirst MA, et al. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 1983; 71:1495-1499. (Pubitemid 13098940)
    • (1983) Journal of Clinical Investigation , vol.71 , Issue.5 , pp. 1495-1499
    • Loose, D.S.1    Kan, P.B.2    Hirst, M.A.3
  • 21
    • 53749090666 scopus 로고    scopus 로고
    • Phase i clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
    • Attard G, Reid AH, Yap TA, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 2008; 26:4563-4571.
    • (2008) J Clin Oncol , vol.26 , pp. 4563-4571
    • Attard, G.1    Reid, A.H.2    Yap, T.A.3
  • 22
    • 77951518711 scopus 로고    scopus 로고
    • Significant and sustained antitumor activity in postdocetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
    • Reid AH, Attard G, Danila DC, et al. Significant and sustained antitumor activity in postdocetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J Clin Oncol 2010; 28:1489-1495.
    • (2010) J Clin Oncol , vol.28 , pp. 1489-1495
    • Reid, A.H.1    Attard, G.2    Danila, D.C.3
  • 23
    • 77951591066 scopus 로고    scopus 로고
    • Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxeltreated castration-resistant prostate cancer
    • Danila DC, Morris MJ, de Bono JS, et al. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxeltreated castration-resistant prostate cancer. J Clin Oncol 2010; 28:1496-1501.
    • (2010) J Clin Oncol , vol.28 , pp. 1496-1501
    • Danila, D.C.1    Morris, M.J.2    De Bono, J.S.3
  • 24
    • 79957443342 scopus 로고    scopus 로고
    • Abiraterone and increased survival in metastatic prostate cancer
    • de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011; 364:1995-2005.
    • (2011) N Engl J Med , vol.364 , pp. 1995-2005
    • De Bono, J.S.1    Logothetis, C.J.2    Molina, A.3
  • 25
    • 84856780403 scopus 로고    scopus 로고
    • Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer
    • Kaku T, Hitaka T, Ojida A, et al. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. Bioorg Med Chem 2011; 19:6383-6399.
    • (2011) Bioorg Med Chem , vol.19 , pp. 6383-6399
    • Kaku, T.1    Hitaka, T.2    Ojida, A.3
  • 26
    • 77956235472 scopus 로고    scopus 로고
    • Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer
    • Yamaoka M, Hara T, Kusaka M. Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer. Clin Cancer Res 2010; 16:4319-4324.
    • (2010) Clin Cancer Res , vol.16 , pp. 4319-4324
    • Yamaoka, M.1    Hara, T.2    Kusaka, M.3
  • 27
    • 78649523986 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostate cancer: A phase I/II, open-label study
    • abstr 3084
    • Dreicer R, Agus DB, MacVicar GR, et al. Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostate cancer: a phase I/II, open-label study. J Clin Oncol 2010; 28:abstr 3084.
    • (2010) J Clin Oncol , pp. 28
    • Dreicer, R.1    Agus, D.B.2    MacVicar, G.R.3
  • 28
    • 80053063302 scopus 로고    scopus 로고
    • Safety, efficacy, and pharmacodynamics of the investigational agent TAK-700 in metastatic castration-resistant prostate cancer (mCRPC): Updated data from a phase I/II study
    • abstr 4531
    • Agus DB, Stadler WM, Shevrin DH, et al. Safety, efficacy, and pharmacodynamics of the investigational agent TAK-700 in metastatic castration-resistant prostate cancer (mCRPC): updated data from a phase I/II study. J Clin Oncol 2011; 29:abstr 4531.
    • (2011) J Clin Oncol , pp. 29
    • Agus, D.B.1    Stadler, W.M.2    Shevrin, D.H.3
  • 29
    • 53349101498 scopus 로고    scopus 로고
    • Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole- 1-yl)androsta-5,16-diene in prostate cancer
    • Vasaitis T, Belosay A, Schayowitz A, et al. Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20- lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Mol Cancer Ther 2008; 7:2348-2357.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2348-2357
    • Vasaitis, T.1    Belosay, A.2    Schayowitz, A.3
  • 30
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009; 324:787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3
  • 31
    • 77952105685 scopus 로고    scopus 로고
    • Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study
    • Scher HI, Beer TM, Higano CS, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 2010; 375:1437-1446.
    • (2010) Lancet , vol.375 , pp. 1437-1446
    • Scher, H.I.1    Beer, T.M.2    Higano, C.S.3
  • 33
    • 79960435644 scopus 로고    scopus 로고
    • Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response
    • Ryan CJ, Shah S, Efstathiou E, et al. Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response. Clin Cancer Res 2011; 17:4854-4861.
    • (2011) Clin Cancer Res , vol.17 , pp. 4854-4861
    • Ryan, C.J.1    Shah, S.2    Efstathiou, E.3
  • 34
    • 80054021222 scopus 로고    scopus 로고
    • Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
    • Cai C, Chen S, Ng P, et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res 2011; 71:6503-6513.
    • (2011) Cancer Res , vol.71 , pp. 6503-6513
    • Cai, C.1    Chen, S.2    Ng, P.3
  • 35
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • Mostaghel EA, Marck BT, Plymate SR, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011; 17:5913-5925.
    • (2011) Clin Cancer Res , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3
  • 36
    • 79951726954 scopus 로고    scopus 로고
    • Discovery of substituted 3-(phenylamino) benzoic acids as potent and selective inhibitors of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3)
    • Adeniji AO, Twenter BM, Byrns MC, et al. Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3). Bioorg Med Chem Lett 2011; 21:1464-1468.
    • (2011) Bioorg Med Chem Lett , vol.21 , pp. 1464-1468
    • Adeniji, A.O.1    Twenter, B.M.2    Byrns, M.C.3
  • 37
    • 80051963331 scopus 로고    scopus 로고
    • Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    • Chang KH, Li R, Papari-Zareei M, et al. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. Proc Natl Acad Sci USA 2011; 108:13728-13733.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 13728-13733
    • Chang, K.H.1    Li, R.2    Papari-Zareei, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.