-
1
-
-
84928580276
-
Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate
-
Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1941; 1:293-297.
-
(1941)
Cancer Res
, vol.1
, pp. 293-297
-
-
Huggins, C.1
Hodges, C.V.2
-
2
-
-
0001189211
-
Studies on prostatic cancer: II the effects of castration on advanced carcinoma of the prostate gland
-
Huggins C, Stevens RE Jr, Hodges CV. Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 1941; 43:209-223.
-
(1941)
Arch Surg
, vol.43
, pp. 209-223
-
-
Huggins, C.1
Stevens Jr., R.E.2
Hodges, C.V.3
-
3
-
-
77951523950
-
Phase i clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castrationresistant prostate cancer who received prior ketoconazole therapy
-
Ryan CJ, Smith MR, Fong L, et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castrationresistant prostate cancer who received prior ketoconazole therapy. J Clin Oncol 2010; 28:1481-1488.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1481-1488
-
-
Ryan, C.J.1
Smith, M.R.2
Fong, L.3
-
4
-
-
0842311632
-
The androgen axis in recurrent prostate cancer
-
DOI 10.1158/1078-0432.CCR-1146-03
-
Mohler JL, Gregory CW, Ford OH 3rd, et al. The androgen axis in recurrent prostate cancer. Clin Cancer Res 2004; 10:440-448. (Pubitemid 38173980)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.2
, pp. 440-448
-
-
Mohler, J.L.1
Gregory, C.W.2
Ford III, H.3
Kim, D.4
Weaver, C.M.5
Petrusz, P.6
Wilson, E.M.7
French, F.S.8
-
5
-
-
49249119358
-
Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
-
Montgomery RB, Mostaghel EA, Vessella R, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 2008; 68:4447-4454.
-
(2008)
Cancer Res
, vol.68
, pp. 4447-4454
-
-
Montgomery, R.B.1
Mostaghel, E.A.2
Vessella, R.3
-
6
-
-
51049098138
-
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
-
Locke JA, Guns ES, Lubik AA, et al. Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 2008; 68:6407-6415.
-
(2008)
Cancer Res
, vol.68
, pp. 6407-6415
-
-
Locke, J.A.1
Guns, E.S.2
Lubik, A.A.3
-
7
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
DOI 10.1038/nm972
-
Chen CD, Welsbie DS, Tran C, et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 2004; 10:33-39. (Pubitemid 38524696)
-
(2004)
Nature Medicine
, vol.10
, Issue.1
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
Baek, S.H.4
Chen, R.5
Vessella, R.6
Rosenfeld, M.G.7
Sawyers, C.L.8
-
8
-
-
76149137405
-
Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
-
Leon CG, Locke JA, Adomat HH, et al. Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate 2010; 70:390-400.
-
(2010)
Prostate
, vol.70
, pp. 390-400
-
-
Leon, C.G.1
Locke, J.A.2
Adomat, H.H.3
-
9
-
-
0035328474
-
Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
-
Linja MJ, Savinainen KJ, Saramaki OR, et al. Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer. Cancer Res 2001; 61:3550-3555. (Pubitemid 32694958)
-
(2001)
Cancer Research
, vol.61
, Issue.9
, pp. 3550-3555
-
-
Linja, M.J.1
Savinainen, K.J.2
Saramaki, O.R.3
Tammela, T.L.J.4
Vessella, R.L.5
Visakorpi, T.6
-
10
-
-
79957532351
-
Evolving therapeutic paradigms for advanced prostate cancer
-
8
-
Ruch JM, Hussain MH. Evolving therapeutic paradigms for advanced prostate cancer. Oncology (Williston Park) 2011; 25:496-504; 8.
-
(2011)
Oncology (Williston Park)
, vol.25
, pp. 496-504
-
-
Ruch, J.M.1
Hussain, M.H.2
-
11
-
-
80053071543
-
Androgen receptor rediscovered: The new biology and targeting the androgen receptor therapeutically
-
Ryan CJ, Tindall DJ. Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically. J Clin Oncol 2011; 29:3651-3658.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3651-3658
-
-
Ryan, C.J.1
Tindall, D.J.2
-
12
-
-
77955296562
-
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
-
Sun S, Sprenger CC, Vessella RL, et al. Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 2010; 120:2715-2730.
-
(2010)
J Clin Invest
, vol.120
, pp. 2715-2730
-
-
Sun, S.1
Sprenger, C.C.2
Vessella, R.L.3
-
13
-
-
0029011116
-
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
-
Taplin ME, Bubley GJ, Shuster TD, et al. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N Engl J Med 1995; 332:1393-1398.
-
(1995)
N Engl J Med
, vol.332
, pp. 1393-1398
-
-
Taplin, M.E.1
Bubley, G.J.2
Shuster, T.D.3
-
14
-
-
0042130389
-
Androgen receptor mutations in androgen-independent prostate cancer: Cancer and leukemia group B study 9663
-
DOI 10.1200/JCO.2003.11.102
-
Taplin ME, Rajeshkumar B, Halabi S, et al. Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663. J Clin Oncol 2003; 21:2673-2678. (Pubitemid 46606310)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.14
, pp. 2673-2678
-
-
Taplin, M.-E.1
Rajeshkumar, B.2
Halabi, S.3
Werner, C.P.4
Woda, B.A.5
Picus, J.6
Stadler, W.7
Hayes, D.F.8
Kantoff, P.W.9
Vogelzang, N.J.10
Small, E.J.11
-
15
-
-
79959294088
-
SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer
-
Yang M, Xie W, Mostaghel E, et al. SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 2011; 29:2565-2573.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2565-2573
-
-
Yang, M.1
Xie, W.2
Mostaghel, E.3
-
16
-
-
0006791684
-
Effect of bilateral adrenalectomy on certain human tumors
-
Huggins C, Bergenstal DM. Effect of bilateral adrenalectomy on certain human tumors. Proc Natl Acad Sci USA 1952; 38:73-76.
-
(1952)
Proc Natl Acad Sci USA
, vol.38
, pp. 73-76
-
-
Huggins, C.1
Bergenstal, D.M.2
-
17
-
-
80053940699
-
Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
-
Cai C, Balk SP. Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy. Endocr Relat Cancer 2011; 18:R175-R182.
-
(2011)
Endocr Relat Cancer
, vol.18
-
-
Cai, C.1
Balk, S.P.2
-
18
-
-
8344219790
-
Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy
-
DOI 10.1097/00001813-200410000-00004
-
Kruit WH, Stoter G, Klijn JG. Effect of combination therapy with aminoglutethimide and hydrocortisone on prostate-specific antigen response in metastatic prostate cancer refractory to standard endocrine therapy. Anticancer Drugs 2004; 15:843-847. (Pubitemid 39482924)
-
(2004)
Anti-Cancer Drugs
, vol.15
, Issue.9
, pp. 843-847
-
-
Kruit, W.H.J.1
Stoter, G.2
Klijn, J.G.M.3
-
19
-
-
0020531983
-
Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes
-
Loose DS, Kan PB, Hirst MA, et al. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 1983; 71:1495-1499. (Pubitemid 13098940)
-
(1983)
Journal of Clinical Investigation
, vol.71
, Issue.5
, pp. 1495-1499
-
-
Loose, D.S.1
Kan, P.B.2
Hirst, M.A.3
-
20
-
-
1842457650
-
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: A phase III trial (CALGB 9583)
-
DOI 10.1200/JCO.2004.06.037
-
Small EJ, Halabi S, Dawson NA, et al. Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583). J Clin Oncol 2004; 22:1025-1033. (Pubitemid 41095034)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.6
, pp. 1025-1033
-
-
Small, E.J.1
Halabi, S.2
Dawson, N.A.3
Stadler, W.M.4
Rini, B.I.5
Picus, J.6
Gable, P.7
Torti, F.M.8
Kaplan, E.9
Vogelzang, N.J.10
-
21
-
-
53749090666
-
Phase i clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven
-
Attard G, Reid AH, Yap TA, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 2008; 26:4563-4571.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4563-4571
-
-
Attard, G.1
Reid, A.H.2
Yap, T.A.3
-
22
-
-
77951518711
-
Significant and sustained antitumor activity in postdocetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate
-
Reid AH, Attard G, Danila DC, et al. Significant and sustained antitumor activity in postdocetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J Clin Oncol 2010; 28:1489-1495.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1489-1495
-
-
Reid, A.H.1
Attard, G.2
Danila, D.C.3
-
23
-
-
77951591066
-
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxeltreated castration-resistant prostate cancer
-
Danila DC, Morris MJ, de Bono JS, et al. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxeltreated castration-resistant prostate cancer. J Clin Oncol 2010; 28:1496-1501.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1496-1501
-
-
Danila, D.C.1
Morris, M.J.2
De Bono, J.S.3
-
24
-
-
79957443342
-
Abiraterone and increased survival in metastatic prostate cancer
-
de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 2011; 364:1995-2005.
-
(2011)
N Engl J Med
, vol.364
, pp. 1995-2005
-
-
De Bono, J.S.1
Logothetis, C.J.2
Molina, A.3
-
25
-
-
84856780403
-
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer
-
Kaku T, Hitaka T, Ojida A, et al. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. Bioorg Med Chem 2011; 19:6383-6399.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 6383-6399
-
-
Kaku, T.1
Hitaka, T.2
Ojida, A.3
-
26
-
-
77956235472
-
Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer
-
Yamaoka M, Hara T, Kusaka M. Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer. Clin Cancer Res 2010; 16:4319-4324.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4319-4324
-
-
Yamaoka, M.1
Hara, T.2
Kusaka, M.3
-
27
-
-
78649523986
-
Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostate cancer: A phase I/II, open-label study
-
abstr 3084
-
Dreicer R, Agus DB, MacVicar GR, et al. Safety, pharmacokinetics, and efficacy of TAK-700 in metastatic castration-resistant prostate cancer: a phase I/II, open-label study. J Clin Oncol 2010; 28:abstr 3084.
-
(2010)
J Clin Oncol
, pp. 28
-
-
Dreicer, R.1
Agus, D.B.2
MacVicar, G.R.3
-
28
-
-
80053063302
-
Safety, efficacy, and pharmacodynamics of the investigational agent TAK-700 in metastatic castration-resistant prostate cancer (mCRPC): Updated data from a phase I/II study
-
abstr 4531
-
Agus DB, Stadler WM, Shevrin DH, et al. Safety, efficacy, and pharmacodynamics of the investigational agent TAK-700 in metastatic castration-resistant prostate cancer (mCRPC): updated data from a phase I/II study. J Clin Oncol 2011; 29:abstr 4531.
-
(2011)
J Clin Oncol
, pp. 29
-
-
Agus, D.B.1
Stadler, W.M.2
Shevrin, D.H.3
-
29
-
-
53349101498
-
Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole- 1-yl)androsta-5,16-diene in prostate cancer
-
Vasaitis T, Belosay A, Schayowitz A, et al. Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20- lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer. Mol Cancer Ther 2008; 7:2348-2357.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2348-2357
-
-
Vasaitis, T.1
Belosay, A.2
Schayowitz, A.3
-
30
-
-
65649090203
-
Development of a second-generation antiandrogen for treatment of advanced prostate cancer
-
Tran C, Ouk S, Clegg NJ, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009; 324:787-790.
-
(2009)
Science
, vol.324
, pp. 787-790
-
-
Tran, C.1
Ouk, S.2
Clegg, N.J.3
-
31
-
-
77952105685
-
Antitumour activity of MDV3100 in castration-resistant prostate cancer: A phase 1-2 study
-
Scher HI, Beer TM, Higano CS, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet 2010; 375:1437-1446.
-
(2010)
Lancet
, vol.375
, pp. 1437-1446
-
-
Scher, H.I.1
Beer, T.M.2
Higano, C.S.3
-
33
-
-
79960435644
-
Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response
-
Ryan CJ, Shah S, Efstathiou E, et al. Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response. Clin Cancer Res 2011; 17:4854-4861.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4854-4861
-
-
Ryan, C.J.1
Shah, S.2
Efstathiou, E.3
-
34
-
-
80054021222
-
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors
-
Cai C, Chen S, Ng P, et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors. Cancer Res 2011; 71:6503-6513.
-
(2011)
Cancer Res
, vol.71
, pp. 6503-6513
-
-
Cai, C.1
Chen, S.2
Ng, P.3
-
35
-
-
80052827038
-
Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
-
Mostaghel EA, Marck BT, Plymate SR, et al. Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants. Clin Cancer Res 2011; 17:5913-5925.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5913-5925
-
-
Mostaghel, E.A.1
Marck, B.T.2
Plymate, S.R.3
-
36
-
-
79951726954
-
Discovery of substituted 3-(phenylamino) benzoic acids as potent and selective inhibitors of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3)
-
Adeniji AO, Twenter BM, Byrns MC, et al. Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3). Bioorg Med Chem Lett 2011; 21:1464-1468.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 1464-1468
-
-
Adeniji, A.O.1
Twenter, B.M.2
Byrns, M.C.3
-
37
-
-
80051963331
-
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
-
Chang KH, Li R, Papari-Zareei M, et al. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer. Proc Natl Acad Sci USA 2011; 108:13728-13733.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 13728-13733
-
-
Chang, K.H.1
Li, R.2
Papari-Zareei, M.3
|