Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5442-5445

  Bradbury, Robert H ^a   Hales, Neil J ^a   Rabow, Alfred A ^a   Walker, Graeme E ^a   Acton, David G ^a   Andrews, David M ^a   Ballard, Peter ^a   Brooks, Nigel A N ^a   Colclough, Nicola ^a   Girdwood, Alan ^a   Hancox, Urs J ^a   Jones, Owen ^a   Jude, David ^a   Loddick, Sarah A ^a   Mortlock, Andrew A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Androgen antagonist; Androgen receptor downregulator; Prostate cancer

Indexed keywords

6 (1 PIPERIDINYL) 3 (TRIFLUOROMETHYL) [1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE; 6 [4 (4 CYANOBENZYL)PIPERAZIN 1 YL] 3 (TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3 B]PYRIDAZINE; ANDROGEN RECEPTOR; ANTIANDROGEN; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BLOOD LEVEL; DRUG POTENCY; MALE; NONHUMAN; PROSTATE CANCER; RAT; RECEPTOR DOWN REGULATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROSTATIC NEOPLASMS; PYRIDAZINES; RECEPTORS, ANDROGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051940007     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.122     Document Type: Article

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