Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals

Leukemia

Volumn 27, Issue 3, 2013, Pages 754-757

  Du, J ^a   Liu, Y ^a   Meline, B ^b   Kong, G ^a   Tan, L X ^b   Lo, J C ^b   Wang, J ^a   Ranheim, E ^c   Zhang, L ^b   Chang, Y I ^a   Ryu, M J ^a   Zhang, J F ^a   Zhang, J ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD44V ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYINOSINIC POLYCYTIDYLIC ACID; STAT5 PROTEIN;

BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; LETTER; MOUSE; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN WEIGHT; SPLENOMEGALY; SURVIVAL;

ANIMALS; ANTIGENS, CD44; BONE MARROW TRANSPLANTATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; INTEGRASES; MICE; MICE, KNOCKOUT; MUTATION; MYELOPROLIFERATIVE DISORDERS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 84875209290     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.251     Document Type: Letter

References (15)

1. Ponta H, Sherman L, Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003; 4: 33-45.
2. Krause DS, Lazarides K, von Andrian UH, Van Etten RA. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med 2006; 12: 1175-1180.
3. Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006; 12: 1167-1174.
4. Cheng C, Yaffe MB, Sharp PA. A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev 2006; 20: 1715-1720.
5. Kindler T, Cornejo MG, Scholl C, Liu J, Leeman DS, Haydu JE et al. K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. Blood 2008; 112: 3373-3382.
6. Zhang J, Wang J, Liu Y, Sidik H, Young KH, Lodish HF et al. Oncogenic Krasinduced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 2009; 113: 1304-1314.
7. Wang JY, Liu YG, Li ZY, Wang ZD, Tan LX, Ryu MJ et al. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose-and cell typedependent manner. Blood 2011; 118: 368-379.
8. Cavalcanti Junior GB, Savino W. Pombo-de-Oliveira MS. CD44 expression in T-cell lymphoblastic leukemia. Braz J Med Biol Res 1994; 27: 2259-2266.
9. Chen C, Chang MC, Hsieh RK, Chang YF, Lin J, Tsan KW. Activation of CD44 facilitates DNA repair in T-cell lymphoma but has differential effects on apoptosis induced by chemotherapeutic agents and ionizing radiation. Leuk Lymphoma 2005; 46: 1785-1795.
10. Protin U, Schweighoffer T, Jochum W, Hilberg F. CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets. J Immunol 1999; 163: 4917-4923.
11. Wang JY, Liu YG, Li ZY, Du J, Ryu MJ, Taylor PR et al. Endogenous oncogenic Nras mutation leads to aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 2010; 116: 5991-6002.
12. Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML et al. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol 2009; 7: e59.
13. Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L et al. Deletionbased mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 2010; 116: 5455-5464.
14. Shi M, Dennis K, Peschon JJ, Chandrasekaran R, Mikecz K. Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton. J Immunol 2001; 167: 123-131.
15. Zheng Z, Katoh S, He Q, Oritani K, Miyake K, Lesley J et al. Monoclonal antibodies to CD44 and their influence on hyaluronan recognition. J Cell Biol 1995; 130: 485-495.