No Correlation of hsa-miR-148a with Expression of PXR or CYP3A4 in Human Livers from Chinese Han Population

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Wei, Zhiyun ^a,b   Chen, Mingjie ^a,b   Zhang, Yiting ^a,b   Wang, Xiaofei ^c   Jiang, Songshan ^d   Wang, Yang ^b   Wu, Xi ^b   Qin, Shengying ^b   He, Lin ^a,b   Zhang, Lirong ^c   Xing, Qinghe ^a,b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c ZHENGZHOU UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; HSA MICRORNA 148A; MESSENGER RNA; MICRORNA; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER; LIVER CIRRHOSIS; MALE; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CYTOCHROME P-450 CYP3A; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LIVER; LIVER CIRRHOSIS; MALE; MICRORNAS; MIDDLE AGED; RECEPTORS, STEROID; RNA, MESSENGER;

EID: 84875198183     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059141     Document Type: Article

References (11)

1. Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, et al. (2003) Developmental expression of the major human hepatic CYP3A enzymes. J Pharmacol Exp Ther 307: 573-582.
2. Guengerich FP, (1999) Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39: 1-17.
3. Dresser GK, Spence JD, Bailey DG, (2000) Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition. Clin Pharmacokinet 38: 41-57.
4. Ozdemir V, Kalow W, Tang BK, Paterson AD, Walker SE, et al. (2000) Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. Pharmacogenetics 10: 373-388.
5. Lamba JK, Lin YS, Schuetz EG, Thummel KE, (2002) Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev 54: 1271-1294.
6. Martinez-Jimenez CP, Jover R, Donato MT, Castell JV, Gomez-Lechon MJ, (2007) Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drug Metab 8: 185-194.
7. Nakajima M, Yokoi T, (2011) MicroRNAs from biology to future pharmacotherapy: regulation of cytochrome P450s and nuclear receptors. Pharmacol Ther 131: 330-337.
8. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92: 73-82.
9. Takada T, Ogino M, Miyata M, Shimada M, Nagata K, et al. (2004) Differences in transactivation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor. Drug Metab Pharmacokinet 19: 103-113.
10. Takagi S, Nakajima M, Mohri T, Yokoi T, (2008) Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 283: 9674-9680.
11. Faul F, Erdfelder E, Lang AG, Buchner A, (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39: 175-191.